Search Results

You are looking at 1 - 10 of 726 items for :

  • type 2 diabetes x
  • Refine by access: All content x
Clear All
Jan Christiansen Clinical Biochemistry, Departments of

Search for other papers by Jan Christiansen in
Google Scholar
PubMed
Close
,
Astrid M Kolte Clinical Biochemistry, Departments of

Search for other papers by Astrid M Kolte in
Google Scholar
PubMed
Close
,
Thomas v O Hansen Clinical Biochemistry, Departments of

Search for other papers by Thomas v O Hansen in
Google Scholar
PubMed
Close
, and
Finn C Nielsen Clinical Biochemistry, Departments of

Search for other papers by Finn C Nielsen in
Google Scholar
PubMed
Close

development and are essential for normal embryonic growth and development. Based on a series of genome-wide association (GWA) studies, IMP2 was recently implicated in type 2 diabetes (T2D). Here, we review the molecular properties of the IMP family and IMP2

Free access
Xianjie Wen Division of Endocrinology, Department of Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio, USA
Department of Anesthesiology, The First People’s Hospital of Foshan & Foshan Hospital of Sun Yat-sen University, Guangdong, China

Search for other papers by Xianjie Wen in
Google Scholar
PubMed
Close
and
Yisheng Yang Division of Endocrinology, Department of Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio, USA

Search for other papers by Yisheng Yang in
Google Scholar
PubMed
Close

Introduction Type 1 (T1D) and type 2 diabetes (T2D) share some clinical and pathologic similarities, presenting with hyperglycemia resulting from islet β cell dysfunction and/or defect of insulin action. Hyperglycemia associated with both T1D

Free access
Neil W Salter Departments of, Physiology, Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

Search for other papers by Neil W Salter in
Google Scholar
PubMed
Close
,
Sudharsana R Ande Departments of, Physiology, Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

Search for other papers by Sudharsana R Ande in
Google Scholar
PubMed
Close
,
Hoa K Nguyen Departments of, Physiology, Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

Search for other papers by Hoa K Nguyen in
Google Scholar
PubMed
Close
,
B L Grégoire Nyomba Departments of, Physiology, Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Departments of, Physiology, Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

Search for other papers by B L Grégoire Nyomba in
Google Scholar
PubMed
Close
, and
Suresh Mishra Departments of, Physiology, Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Departments of, Physiology, Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

Search for other papers by Suresh Mishra in
Google Scholar
PubMed
Close

locus for non-insulin-dependent type 2 diabetes in linkage studies and is believed to contain more than one susceptibility gene ( Ji et al . 1997 , Zouali et al . 1997 , Ghosh et al . 1999 ). One such gene is hepatocyte nuclear factor 4α ( HNF4A

Free access
Haihua Yang Division of Endocrinology, Zhengzhou Children’s Hospital, Zhengzhou, Henan, China

Search for other papers by Haihua Yang in
Google Scholar
PubMed
Close
and
Linghai Yang Department of Pharmacology, University of Washington, Seattle, Washington, USA

Search for other papers by Linghai Yang in
Google Scholar
PubMed
Close

– 733 . ( doi:10.1038/35055575 ) Ahren B 2009 Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes . Nature Reviews. Drug Discovery 8 369 – 385 . ( doi:10.1038/nrd2782 ) Almahariq M Mei FC Cheng

Free access
Guojun Shi Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China
Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Guojun Shi in
Google Scholar
PubMed
Close
,
Chen Sun Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China
Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Chen Sun in
Google Scholar
PubMed
Close
,
Weiqiong Gu Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Weiqiong Gu in
Google Scholar
PubMed
Close
,
Minglan Yang Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Minglan Yang in
Google Scholar
PubMed
Close
,
Xiaofang Zhang Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Xiaofang Zhang in
Google Scholar
PubMed
Close
,
Nan Zhai Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Nan Zhai in
Google Scholar
PubMed
Close
,
Yan Lu Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Yan Lu in
Google Scholar
PubMed
Close
,
Zhijian Zhang Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Zhijian Zhang in
Google Scholar
PubMed
Close
,
Peishun Shou Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Peishun Shou in
Google Scholar
PubMed
Close
,
Zhiguo Zhang Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Zhiguo Zhang in
Google Scholar
PubMed
Close
, and
Guang Ning Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China
Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Guang Ning in
Google Scholar
PubMed
Close

patients and their insulin secretion. Figure 1 FFAR2 expression is elevated in the peripheral blood mononuclear cells (PBMCs) of type 1 diabetes (T1D) patients. (A) Relative FFAR2 mRNA expression in PBMCs of patients with recent-onset T1D ( n =33) and

Free access
Heather C Denroche Department of Surgery, BC Children’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada

Search for other papers by Heather C Denroche in
Google Scholar
PubMed
Close
and
C Bruce Verchere Department of Surgery, BC Children’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Department of Pathology and Laboratory Medicine, BC Children’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada

Search for other papers by C Bruce Verchere in
Google Scholar
PubMed
Close

Introduction Islet amyloid polypeptide (IAPP or amylin), the main constituent of insoluble amyloid deposits in pancreatic islets of individuals with type 2 diabetes (T2D), is secreted from pancreatic beta cells at a level of approximately 1

Free access
Thierry Brun Department of Cell Physiology and Metabolism, University Medical Centre, 1211 Geneva 4, Switzerland

Search for other papers by Thierry Brun in
Google Scholar
PubMed
Close
and
Benoit R Gauthier Department of Cell Physiology and Metabolism, University Medical Centre, 1211 Geneva 4, Switzerland

Search for other papers by Benoit R Gauthier in
Google Scholar
PubMed
Close

2030 ( www.who.int/dietphysicalactivity/publications/facts/diabetes/en ). Diabetes mellitus was recently reclassified into three main entities: 1) type 1 diabetes which is linked to selective autoimmune destruction of pancreatic β-cells, 2) type 2

Free access
Mingtong Xu
Search for other papers by Mingtong Xu in
Google Scholar
PubMed
Close
,
Xiaochao Chen Department of Endocrinology, Department of Cardiology, Department of Epidemiology, the Second Affiliated Hospital, Sun Yat-Sen University, 107 Yanjiang Road, Guangzhou 510120, People's Republic of China

Search for other papers by Xiaochao Chen in
Google Scholar
PubMed
Close
,
Li Yan
Search for other papers by Li Yan in
Google Scholar
PubMed
Close
,
Hua Cheng
Search for other papers by Hua Cheng in
Google Scholar
PubMed
Close
, and
Weiqing Chen Department of Endocrinology, Department of Cardiology, Department of Epidemiology, the Second Affiliated Hospital, Sun Yat-Sen University, 107 Yanjiang Road, Guangzhou 510120, People's Republic of China

Search for other papers by Weiqing Chen in
Google Scholar
PubMed
Close

Introduction Diabetic nephropathy is a severe long-term complication of both type 1 and 2 diabetes mellitus, which is considered as one of the leading causes of end-stage renal disease requiring either dialysis or renal transplantation. Although the

Free access
Rachel Njeim Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine and Medical Center, American University of Beirut, Beirut, Lebanon
AUB Diabetes, American University of Beirut, Beirut, Lebanon

Search for other papers by Rachel Njeim in
Google Scholar
PubMed
Close
,
William S Azar Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine and Medical Center, American University of Beirut, Beirut, Lebanon
AUB Diabetes, American University of Beirut, Beirut, Lebanon
Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, District of Colombia, USA

Search for other papers by William S Azar in
Google Scholar
PubMed
Close
,
Angie H Fares Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine and Medical Center, American University of Beirut, Beirut, Lebanon
AUB Diabetes, American University of Beirut, Beirut, Lebanon

Search for other papers by Angie H Fares in
Google Scholar
PubMed
Close
,
Sami T Azar AUB Diabetes, American University of Beirut, Beirut, Lebanon
Department of Internal Medicine, Faculty of Medicine and Medical Center, American University of Beirut, Beirut, Lebanon

Search for other papers by Sami T Azar in
Google Scholar
PubMed
Close
,
Hala Kfoury Kassouf Department of Pathology and Laboratory Medicine, Faculty of Medicine and Medical Center, American University of Beirut, Beirut, Lebanon

Search for other papers by Hala Kfoury Kassouf in
Google Scholar
PubMed
Close
, and
Assaad A Eid Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine and Medical Center, American University of Beirut, Beirut, Lebanon
AUB Diabetes, American University of Beirut, Beirut, Lebanon

Search for other papers by Assaad A Eid in
Google Scholar
PubMed
Close

that results from defects in insulin action, insulin secretion, or both. Despite the different etiologies of type 1 (insulin deficiency) and type 2 diabetes (insulin resistance), both are associated with ‘macrovascular complications’, including

Free access
Young Ho Suh Division of Metabolic Diseases, Department of Biomedical Sciences, National Institute of Health, 5 Nokbun-dong, Eunpyung-gu, Seoul, 122-701, South Korea
Research and Development, GenomicTree, Inc., 461-6 Jonmin-dong, Yusong-gu, Taejon 305-811, South Korea

Search for other papers by Young Ho Suh in
Google Scholar
PubMed
Close
,
Younyoung Kim Division of Metabolic Diseases, Department of Biomedical Sciences, National Institute of Health, 5 Nokbun-dong, Eunpyung-gu, Seoul, 122-701, South Korea
Research and Development, GenomicTree, Inc., 461-6 Jonmin-dong, Yusong-gu, Taejon 305-811, South Korea

Search for other papers by Younyoung Kim in
Google Scholar
PubMed
Close
,
Jeong Hyun Bang Division of Metabolic Diseases, Department of Biomedical Sciences, National Institute of Health, 5 Nokbun-dong, Eunpyung-gu, Seoul, 122-701, South Korea
Research and Development, GenomicTree, Inc., 461-6 Jonmin-dong, Yusong-gu, Taejon 305-811, South Korea

Search for other papers by Jeong Hyun Bang in
Google Scholar
PubMed
Close
,
Kyoung Suk Choi Division of Metabolic Diseases, Department of Biomedical Sciences, National Institute of Health, 5 Nokbun-dong, Eunpyung-gu, Seoul, 122-701, South Korea
Research and Development, GenomicTree, Inc., 461-6 Jonmin-dong, Yusong-gu, Taejon 305-811, South Korea

Search for other papers by Kyoung Suk Choi in
Google Scholar
PubMed
Close
,
June Woo Lee Division of Metabolic Diseases, Department of Biomedical Sciences, National Institute of Health, 5 Nokbun-dong, Eunpyung-gu, Seoul, 122-701, South Korea
Research and Development, GenomicTree, Inc., 461-6 Jonmin-dong, Yusong-gu, Taejon 305-811, South Korea

Search for other papers by June Woo Lee in
Google Scholar
PubMed
Close
,
Won-Ho Kim Division of Metabolic Diseases, Department of Biomedical Sciences, National Institute of Health, 5 Nokbun-dong, Eunpyung-gu, Seoul, 122-701, South Korea
Research and Development, GenomicTree, Inc., 461-6 Jonmin-dong, Yusong-gu, Taejon 305-811, South Korea

Search for other papers by Won-Ho Kim in
Google Scholar
PubMed
Close
,
Tae Jeong Oh Division of Metabolic Diseases, Department of Biomedical Sciences, National Institute of Health, 5 Nokbun-dong, Eunpyung-gu, Seoul, 122-701, South Korea
Research and Development, GenomicTree, Inc., 461-6 Jonmin-dong, Yusong-gu, Taejon 305-811, South Korea

Search for other papers by Tae Jeong Oh in
Google Scholar
PubMed
Close
,
Sungwhan An Division of Metabolic Diseases, Department of Biomedical Sciences, National Institute of Health, 5 Nokbun-dong, Eunpyung-gu, Seoul, 122-701, South Korea
Research and Development, GenomicTree, Inc., 461-6 Jonmin-dong, Yusong-gu, Taejon 305-811, South Korea

Search for other papers by Sungwhan An in
Google Scholar
PubMed
Close
, and
Myeong Ho Jung Division of Metabolic Diseases, Department of Biomedical Sciences, National Institute of Health, 5 Nokbun-dong, Eunpyung-gu, Seoul, 122-701, South Korea
Research and Development, GenomicTree, Inc., 461-6 Jonmin-dong, Yusong-gu, Taejon 305-811, South Korea

Search for other papers by Myeong Ho Jung in
Google Scholar
PubMed
Close

Introduction Type 2 diabetes mellitus is a common metabolic disease involving abnormal carbohydrate regulation and lipid metabolism by insulin ( Saltiel 2001 ). Insulin resistance, characterized as decreased insulin action on glucose

Free access