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Amy Warner and Jens Mittag

Introduction Thyroid hormone has long been known for its profound effects on the metabolic rate and cardiovascular function ( Magnus-Levy 1895 , Klein & Ojamaa 2001 ). This becomes most evident in hyperthyroidism, which is accompanied by an

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Sogol Gachkar, Sebastian Nock, Cathleen Geissler, Rebecca Oelkrug, Kornelia Johann, Julia Resch, Awahan Rahman, Anders Arner, Henriette Kirchner and Jens Mittag

Introduction Thyroid hormone (TH) is an important regulator of cardiovascular functions. This becomes evident in patients with hyperthyroidism presenting with tachycardia and cardiac hypertrophy, while bradycardia is a characteristic of

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Anne Wulf, Marianne G Wetzel, Maxim Kebenko, Meike Kröger, Angelika Harneit, Jennifer Merz and Joachim M Weitzel

Introduction Thyroid hormone (3,3′,5-tri-iodothyronine; T 3 ) is an essential regulator of brain development, cell differentiation, and metabolic balance ( Yen 2001 ). Thyroid hormone regulates gene expression via binding to thyroid hormone

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Kwang-Huei Lin, Chia-yu Chen, Shen-Liang Chen, Chun-Che Yen, Ya-Hui Huang, Chung-hsuan Shih, Jiann-Jong Shen, Rong-Chi Yang and Chia-Siu Wang

thyroid hormones (THs) positively regulate plasma levels of FN by unknown mechanisms. In addition, Baumgartner-Parzer et al. (1997) also showed that hyperthyroidism is associated with elevated plasma levels of FN. Thus, we focused our study on the

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Maria Nygård, Nathalie Becker, Barbara Demeneix, Katarina Pettersson and Maria Bondesson

Introduction Thyroid hormone (3,5,3-tri-iodothyronine; T3) is an essential regulator of brain development. Supporting this notion, congenital hypothyroidism results in severe and irreversible mental retardation. Thyroid hormones in

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K Alexander Iwen, Rebecca Oelkrug and Georg Brabant

Introduction Thyroid hormones (THs) are key in regulating energy homeostasis in both humans and rodents. Maintaining core body temperature is critical for homeothermic species and thermoregulation requires fine-tuned energy partitioning. Here

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L Quignodon, C Legrand, N Allioli, A Guadaño-Ferraz, J Bernal, J Samarut and F Flamant

Introduction Thyroid hormone (3,5,3′-tri-iodothyronine; T3) is an essential regulator of brain development, congenital hypothyroidism resulting in severe and irreversible mental retardation. T3 directly activates gene expression by

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Isabel Castro, Leah Quisenberry, Rosa-Maria Calvo, Maria-Jesus Obregon and Joaquin Lado-Abeal

, serum rT 3 increases and thyroxine (T 4 ) decreases ( Wartofsky & Burman 1982 , DeGroot 1999 ). As thyroid hormone (TH) increases energy expenditure ( Silva 2006 ), NTIS can be considered an adaptive response to counteract catabolism during fasting and

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Alok Mishra, Xu-guang Zhu, Kai Ge and Sheue-Yann Cheng

Introduction Thyroid hormone (tri-iodothyronine, T 3 ) has long been recognized to play a key role in lipid metabolism and thermogenesis. However, the molecular mechanisms by which T 3 regulates lipid homeostasis have not been fully elucidated. The

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David M Selva and Geoffrey L Hammond

Introduction Thyroid hormones influence plasma sex hormone-binding globulin (SHBG) levels under both normal and pathological conditions ( Anderson 1974 ) by altering the production of SHBG by hepatocytes ( Rosner et al . 1984 ). In addition, blood