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Amy Warner and Jens Mittag

Introduction Thyroid hormone has long been known for its profound effects on the metabolic rate and cardiovascular function ( Magnus-Levy 1895 , Klein & Ojamaa 2001 ). This becomes most evident in hyperthyroidism, which is accompanied by an

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Sogol Gachkar, Sebastian Nock, Cathleen Geissler, Rebecca Oelkrug, Kornelia Johann, Julia Resch, Awahan Rahman, Anders Arner, Henriette Kirchner, and Jens Mittag

Introduction Thyroid hormone (TH) is an important regulator of cardiovascular functions. This becomes evident in patients with hyperthyroidism presenting with tachycardia and cardiac hypertrophy, while bradycardia is a characteristic of

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Maria Nygård, Nathalie Becker, Barbara Demeneix, Katarina Pettersson, and Maria Bondesson

Introduction Thyroid hormone (3,5,3-tri-iodothyronine; T3) is an essential regulator of brain development. Supporting this notion, congenital hypothyroidism results in severe and irreversible mental retardation. Thyroid hormones in

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K Alexander Iwen, Rebecca Oelkrug, and Georg Brabant

Introduction Thyroid hormones (THs) are key in regulating energy homeostasis in both humans and rodents. Maintaining core body temperature is critical for homeothermic species and thermoregulation requires fine-tuned energy partitioning. Here

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Anne Wulf, Marianne G Wetzel, Maxim Kebenko, Meike Kröger, Angelika Harneit, Jennifer Merz, and Joachim M Weitzel

Introduction Thyroid hormone (3,3′,5-tri-iodothyronine; T 3 ) is an essential regulator of brain development, cell differentiation, and metabolic balance ( Yen 2001 ). Thyroid hormone regulates gene expression via binding to thyroid hormone

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Kwang-Huei Lin, Chia-yu Chen, Shen-Liang Chen, Chun-Che Yen, Ya-Hui Huang, Chung-hsuan Shih, Jiann-Jong Shen, Rong-Chi Yang, and Chia-Siu Wang

thyroid hormones (THs) positively regulate plasma levels of FN by unknown mechanisms. In addition, Baumgartner-Parzer et al. (1997) also showed that hyperthyroidism is associated with elevated plasma levels of FN. Thus, we focused our study on the

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L Quignodon, C Legrand, N Allioli, A Guadaño-Ferraz, J Bernal, J Samarut, and F Flamant

Introduction Thyroid hormone (3,5,3′-tri-iodothyronine; T3) is an essential regulator of brain development, congenital hypothyroidism resulting in severe and irreversible mental retardation. T3 directly activates gene expression by

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David M Selva and Geoffrey L Hammond

Introduction Thyroid hormones influence plasma sex hormone-binding globulin (SHBG) levels under both normal and pathological conditions ( Anderson 1974 ) by altering the production of SHBG by hepatocytes ( Rosner et al . 1984 ). In addition, blood

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Wendy M van der Deure, Robin P Peeters, and Theo J Visser

Introduction Thyroid hormone is a pleiotropic hormone with widespread biological actions. The follicular cells of the thyroid gland produce predominantly thyroxine (T 4 ), but it is mainly 3,3′,5-tri-iodothyronine (T 3 ) that binds to the nuclear

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Alok Mishra, Xu-guang Zhu, Kai Ge, and Sheue-Yann Cheng

Introduction Thyroid hormone (tri-iodothyronine, T 3 ) has long been recognized to play a key role in lipid metabolism and thermogenesis. However, the molecular mechanisms by which T 3 regulates lipid homeostasis have not been fully elucidated. The