Filter

Refine by collections

Refine by access

Refine by date

—
  • Print
  • Save

Search Results

You are looking at 1 - 10 of 224 items for :

  • steroidogenesis x
  • Refine by access: All content x
Clear All
Zhigang Hu Geriatric Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA
Division of Endocrinology, Gerontology and Metabolism, Stanford University, Stanford, California, USA

Search for other papers by Zhigang Hu in
Google Scholar
PubMed Close
,
Wen-Jun Shen Geriatric Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA
Division of Endocrinology, Gerontology and Metabolism, Stanford University, Stanford, California, USA

Search for other papers by Wen-Jun Shen in
Google Scholar
PubMed Close
,
Fredric B Kraemer Geriatric Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA
Division of Endocrinology, Gerontology and Metabolism, Stanford University, Stanford, California, USA

Search for other papers by Fredric B Kraemer in
Google Scholar
PubMed Close
, and
Salman Azhar Geriatric Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA
Division of Endocrinology, Gerontology and Metabolism, Stanford University, Stanford, California, USA

Search for other papers by Salman Azhar in
Google Scholar
PubMed Close

the adrenal cortex, ovary, testis and placenta. The synthesis of these steroid hormones (steroidogenesis) involves multiple pathways, as well as sequential actions of steroidogenic enzymes associated with the endoplasmic reticulum (ER) and mitochondria

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0011
Volume/Issue:
Volume 59: Issue 3
Free access
Zhiyu Ma College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China
College of Veterinary Medicine, Yangzhou University, Yangzhou, People’s Republic of China

Search for other papers by Zhiyu Ma in
Google Scholar
PubMed Close
,
Ying Zhang College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Ying Zhang in
Google Scholar
PubMed Close
,
Juan Su College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Juan Su in
Google Scholar
PubMed Close
,
Sheng Yang College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Sheng Yang in
Google Scholar
PubMed Close
,
Wenna Qiao College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Wenna Qiao in
Google Scholar
PubMed Close
,
Xiang Li College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Xiang Li in
Google Scholar
PubMed Close
,
Zhihai Lei College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Zhihai Lei in
Google Scholar
PubMed Close
,
Ling Cheng College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Ling Cheng in
Google Scholar
PubMed Close
,
Na An College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Na An in
Google Scholar
PubMed Close
,
Wenshao Wang College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Wenshao Wang in
Google Scholar
PubMed Close
,
Yanyan Feng College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Yanyan Feng in
Google Scholar
PubMed Close
, and
Jinlong Zhang College of Veterinary Medicine, Yangzhou University, Yangzhou, People’s Republic of China

Search for other papers by Jinlong Zhang in
Google Scholar
PubMed Close

important reproductive organ in male animals, and the steroidogenesis (testosterone synthesis) mainly occurs in Leydig cells ( Dufau 1988 ). Testosterone synthesis is controlled by luteinizing hormone (LH), which is synthesized and secreted in the pituitary

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0242
Volume/Issue:
Volume 61: Issue 1
Free access
J J Allen Department of Biomedical Sciences, Cornell University, Ithaca, New York, USA

Search for other papers by J J Allen in
Google Scholar
PubMed Close
,
S L Herrick Department of Biomedical Sciences, Cornell University, Ithaca, New York, USA

Search for other papers by S L Herrick in
Google Scholar
PubMed Close
, and
J E Fortune Department of Biomedical Sciences, Cornell University, Ithaca, New York, USA

Search for other papers by J E Fortune in
Google Scholar
PubMed Close

about the mechanisms that regulate steroidogenesis during fetal life, particularly at this critical time of development. In adult mammalian ovaries, the production of sex steroids from cholesterol is regulated by the gonadotropins, luteinizing hormone

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-16-0152
Volume/Issue:
Volume 57: Issue 4
Free access
Colin R Jefcoate Department of Cell and Regenerative Biology and the Endocrinology and Reproductive Physiology Program, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

Search for other papers by Colin R Jefcoate in
Google Scholar
PubMed Close
and
Jinwoo Lee Department of Cell and Regenerative Biology and the Endocrinology and Reproductive Physiology Program, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

Search for other papers by Jinwoo Lee in
Google Scholar
PubMed Close

significant effect on their activity but is typically a local change that benefits from analysis at the single cell level. Here, we focus on the Steroidogenesis Acute Regulator (STAR) as an intracellular organizer of such processes. We aim to supplement many

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-17-0281
Volume/Issue:
Volume 60: Issue 4
Free access
Trinidad Raices Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental (IBYME) – Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina

Search for other papers by Trinidad Raices in
Google Scholar
PubMed Close
,
María Luisa Varela Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental (IBYME) – Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina

Search for other papers by María Luisa Varela in
Google Scholar
PubMed Close
,
Casandra Margarita Monzón Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental (IBYME) – Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina

Search for other papers by Casandra Margarita Monzón in
Google Scholar
PubMed Close
,
María Florencia Correa Torrado Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental (IBYME) – Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina

Search for other papers by María Florencia Correa Torrado in
Google Scholar
PubMed Close
,
Romina María Pagotto Unidad de Biología Celular, Institut Pasteur, Montevideo, Uruguay

Search for other papers by Romina María Pagotto in
Google Scholar
PubMed Close
,
Marcos Besio Moreno Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental (IBYME) – Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina

Search for other papers by Marcos Besio Moreno in
Google Scholar
PubMed Close
,
Carolina Mondillo Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental (IBYME) – Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina

Search for other papers by Carolina Mondillo in
Google Scholar
PubMed Close
,
Omar Pedro Pignataro Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental (IBYME) – Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

Search for other papers by Omar Pedro Pignataro in
Google Scholar
PubMed Close
, and
Elba Nora Pereyra Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental (IBYME) – Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina

Search for other papers by Elba Nora Pereyra in
Google Scholar
PubMed Close

correct development and function of the male reproductive system ( Ye et al. 2017 ). Several paracrine/autocrine factors, apart from the canonical control by the hypothalamic–pituitary–gonadal axis, have been credited with steroidogenesis and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-19-0063
Volume/Issue:
Volume 63: Issue 3
Free access
Houssein S Abdou Reproduction, Mother and Youth Health, CHUQ Research Centre, Quebec, Canada

Search for other papers by Houssein S Abdou in
Google Scholar
PubMed Close
,
Nicholas M Robert Reproduction, Mother and Youth Health, CHUQ Research Centre, Quebec, Canada

Search for other papers by Nicholas M Robert in
Google Scholar
PubMed Close
, and
Jacques J Tremblay Reproduction, Mother and Youth Health, CHUQ Research Centre, Quebec, Canada
Centre for Research in Biology of Reproduction, Department of Obstetrics, Gynecology, and Reproduction, Faculty of Medicine, Université Laval, Quebec, Canada

Search for other papers by Jacques J Tremblay in
Google Scholar
PubMed Close

gene expression and ultimately a physiological response, i.e. enhanced steroid hormone biosynthesis. Previously, the classical cAMP pathway was thought to account for most of the LH-induced steroidogenesis in Leydig cells (reviewed in Hansson et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-15-0202
Volume/Issue:
Volume 56: Issue 3
Free access
Salman Azhar Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California, USA
Division of Endocrinology, Gerontology and Metabolism, Stanford University, Stanford University, Stanford, California, USA
Stanford Diabetes Research Center, Stanford, California, USA

Search for other papers by Salman Azhar in
Google Scholar
PubMed Close
,
Dachuan Dong Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California, USA
Division of Endocrinology, Gerontology and Metabolism, Stanford University, Stanford University, Stanford, California, USA

Search for other papers by Dachuan Dong in
Google Scholar
PubMed Close
,
Wen-Jun Shen Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California, USA
Division of Endocrinology, Gerontology and Metabolism, Stanford University, Stanford University, Stanford, California, USA

Search for other papers by Wen-Jun Shen in
Google Scholar
PubMed Close
,
Zhigang Hu Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Science, Nanjing Normal University, Nanjing, China

Search for other papers by Zhigang Hu in
Google Scholar
PubMed Close
, and
Fredric B Kraemer Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California, USA
Division of Endocrinology, Gerontology and Metabolism, Stanford University, Stanford University, Stanford, California, USA
Stanford Diabetes Research Center, Stanford, California, USA

Search for other papers by Fredric B Kraemer in
Google Scholar
PubMed Close

transport to and within the mitochondria for side chain cleavage by CYP11A1 (P450scc) occurring within minutes, reflecting the acute regulation of steroidogenesis ( Miller & Bose 2011 , Hattangady et al . 2012 , Shen et al . 2016 a , Selvaraj et al

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-19-0105
Volume/Issue:
Volume 64: Issue 1
Free access
Syed Kashif Zaidi Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA
Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

Search for other papers by Syed Kashif Zaidi in
Google Scholar
PubMed Close
,
Wen-Jun Shen Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA
Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

Search for other papers by Wen-Jun Shen in
Google Scholar
PubMed Close
,
Stefanie Bittner Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

Search for other papers by Stefanie Bittner in
Google Scholar
PubMed Close
,
Alex Bittner Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

Search for other papers by Alex Bittner in
Google Scholar
PubMed Close
,
Mark P McLean Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

Search for other papers by Mark P McLean in
Google Scholar
PubMed Close
,
Jiahuai Han Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

Search for other papers by Jiahuai Han in
Google Scholar
PubMed Close
,
Roger J Davis Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

Search for other papers by Roger J Davis in
Google Scholar
PubMed Close
,
Fredric B Kraemer Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA
Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

Search for other papers by Fredric B Kraemer in
Google Scholar
PubMed Close
, and
Salman Azhar Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA
Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

Search for other papers by Salman Azhar in
Google Scholar
PubMed Close

/2 nor JNK1/2 was altered during aging ( Abidi et al . 2008 a ). We also showed that the use of p38 MAPK inhibitors (SB203580 and SB202190) and antioxidants (NAC and MnTMPyP) partially restored the steroidogenesis in adrenal cells from old animals

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-13-0287
Volume/Issue:
Volume 53: Issue 1
Free access
N Renlund Department of Woman and Child Health, Pediatric Endocrinology Unit Q2:08, Karolinska Institute & University Hospital, Astrid Lindgren Children’s Hospital, SE-17176 Stockholm, Sweden
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA

Search for other papers by N Renlund in
Google Scholar
PubMed Close
,
Y Jo Department of Woman and Child Health, Pediatric Endocrinology Unit Q2:08, Karolinska Institute & University Hospital, Astrid Lindgren Children’s Hospital, SE-17176 Stockholm, Sweden
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA

Search for other papers by Y Jo in
Google Scholar
PubMed Close
,
I Svechnikova Department of Woman and Child Health, Pediatric Endocrinology Unit Q2:08, Karolinska Institute & University Hospital, Astrid Lindgren Children’s Hospital, SE-17176 Stockholm, Sweden
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA

Search for other papers by I Svechnikova in
Google Scholar
PubMed Close
,
M Holst Department of Woman and Child Health, Pediatric Endocrinology Unit Q2:08, Karolinska Institute & University Hospital, Astrid Lindgren Children’s Hospital, SE-17176 Stockholm, Sweden
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA

Search for other papers by M Holst in
Google Scholar
PubMed Close
,
D M Stocco Department of Woman and Child Health, Pediatric Endocrinology Unit Q2:08, Karolinska Institute & University Hospital, Astrid Lindgren Children’s Hospital, SE-17176 Stockholm, Sweden
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA

Search for other papers by D M Stocco in
Google Scholar
PubMed Close
,
O Söder Department of Woman and Child Health, Pediatric Endocrinology Unit Q2:08, Karolinska Institute & University Hospital, Astrid Lindgren Children’s Hospital, SE-17176 Stockholm, Sweden
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA

Search for other papers by O Söder in
Google Scholar
PubMed Close
, and
K Svechnikov Department of Woman and Child Health, Pediatric Endocrinology Unit Q2:08, Karolinska Institute & University Hospital, Astrid Lindgren Children’s Hospital, SE-17176 Stockholm, Sweden
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA

Search for other papers by K Svechnikov in
Google Scholar
PubMed Close

signaling pathway(s) and, moreover, may be involved in the regulation of steroidogenesis by immature Leydig cells. In addition, our most recent findings that growth hormone- and insulin-like growth factor-I (IGF-I)-stimulated steroido-genesis in immature

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01963
Volume/Issue:
Volume 36: Issue 2
Free access
Pulak R Manna Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

Search for other papers by Pulak R Manna in
Google Scholar
PubMed Close
,
Syam P Chandrala Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

Search for other papers by Syam P Chandrala in
Google Scholar
PubMed Close
,
Youngah Jo Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

Search for other papers by Youngah Jo in
Google Scholar
PubMed Close
, and
Douglas M Stocco Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA

Search for other papers by Douglas M Stocco in
Google Scholar
PubMed Close

Introduction Regulation of various Leydig cell functions, including steroidogenesis, are predominantly mediated by luteinizing hormone/chorionic gonadotropin (LH/CG) through the involvement of multiple signaling pathways ( Dufau 1988

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.02065
Volume/Issue:
Volume 37: Issue 1
Free access