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Fetal Medicine Unit, St. George’s Hospital, London, UK
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and more than 10 weeks gestation ( Robson et al. 2012 , Wallace et al. 2015 ). Inadequate trophoblast invasion and reduced spiral artery remodelling are associated with pre-eclampsia and foetal growth restriction (FGR) ( Pijnenborg et al. 1991
Department of Obstetrics and Gynaecology, St George’s Hospital, London SW17 0QT, UK
Bruker Daltonics Limited, Coventry CV4 9GH, UK
National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
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Department of Obstetrics and Gynaecology, St George’s Hospital, London SW17 0QT, UK
Bruker Daltonics Limited, Coventry CV4 9GH, UK
National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
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Department of Obstetrics and Gynaecology, St George’s Hospital, London SW17 0QT, UK
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National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
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Department of Obstetrics and Gynaecology, St George’s Hospital, London SW17 0QT, UK
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National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
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Department of Obstetrics and Gynaecology, St George’s Hospital, London SW17 0QT, UK
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National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
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Department of Obstetrics and Gynaecology, St George’s Hospital, London SW17 0QT, UK
Bruker Daltonics Limited, Coventry CV4 9GH, UK
National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
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Department of Obstetrics and Gynaecology, St George’s Hospital, London SW17 0QT, UK
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Department of Obstetrics and Gynaecology, St George’s Hospital, London SW17 0QT, UK
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Introduction The placenta is known to control the mother’s metabolism for the benefit of the foetus often, as in pre-eclampsia, to the mother’s detriment. In this, it is comparable to parasites which have also evolved sophisticated
Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China
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Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China
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Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China
Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Science, Shandong Normal University, Ji’nan, Shandong, China
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.11.6609 Nishizawa H Pryor-Koishi K Kato T Kowa H Kurahashi H Udagawa Y 2007 Microarray analysis of differentially expressed fetal genes in placental tissue derived from early and late onset severe pre-eclampsia . Placenta 28 487 – 497 . ( https://doi.org/10
Obstetrics and Gynaecology, Monash University, Clayton, Australia
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Obstetrics and Gynaecology, Monash University, Clayton, Australia
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Obstetrics and Gynaecology, Monash University, Clayton, Australia
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show vascular remodelling and hence is not able to model diseases such as pre-eclampsia, placenta accreta or recurrent miscarriage due to inadequate angiogenesis of the spiral arterioles. This emphasises the important research and clinical translation
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Department of Pathophysiology, Department of Physiology, School of Basic Medical Sciences, Capital Medical University, 10 Xitoutiao, You An Men, Beijing 100069, People's Republic of China
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KH 2009 Angiotensin II type 1 and 2 receptors polymorphisms in pre-eclampsia and normal pregnancy in three different populations . Acta Obstetricia et Gynecologica Scandinavica 88 606 – 611 . ( doi:10.1080/00016340902859307 ). Anton L
UQ Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Perinatal Research Centre, The University of Queensland, Brisbane, Queensland, Australia
UQ Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Perinatal Research Centre, The University of Queensland, Brisbane, Queensland, Australia
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UQ Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Perinatal Research Centre, The University of Queensland, Brisbane, Queensland, Australia
UQ Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Perinatal Research Centre, The University of Queensland, Brisbane, Queensland, Australia
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UQ Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Perinatal Research Centre, The University of Queensland, Brisbane, Queensland, Australia
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. 2010 ). Obesity in pregnancy is associated with substantially increased risks for both mother and infant ( Heslehurst et al . 2008 ). Gestational diabetes, pre-eclampsia, Caesarean section, instrumental vaginal delivery, birth trauma and pelvic floor
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Danisman N 2010 Association of maternal serum high sensitive C-reactive protein level with body mass index and severity of pre-eclampsia at third trimester . Journal of Obstetrics and Gynaecology Research 36 970 – 977 . ( https://doi.org/10
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-cell subsets . Immunological Reviews 252 41 – 51 . ( https://doi.org/10.1111/imr.12033 ) Redman CW Sargent IL 2010 Immunology of pre-eclampsia . American Journal of Reproductive Immunology 63 534 – 543 . ( https://doi.org/10.1111/j.1600
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10.1053/j.semperi.2007.11.004 Bartsch E Medcalf KE Park AL Ray JG & High Risk of Pre-eclampsia Identification G 2016 Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of
Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, California, USA
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Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, California, USA
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Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, California, USA
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direct targets of placental Sirt1. Sirt1-PPAR γ signaling in placental disease Alterations in trophoblast differentiation and placental development are associated with numerous pregnancy complications, including miscarriage, pre-eclampsia