Search Results

You are looking at 1 - 10 of 328 items for :

  • pancreatic β-cell x
Clear All
Free access

Gerald Thiel, Isabelle Müller and Oliver G Rössler

(ankyrin). Many biological functions have been connected with TRP channel activation, including regulation of Ca 2 + homeostasis, tumorigenesis, sensory temperature, and pain sensation. In pancreatic β-cells, several members of the TRP family of cation

Free access

Amanda M Ackermann and Maureen Gannon

Introduction An organism’s β-cell mass is determined by the number and the size of its pancreatic β-cells. This unique cell population is required for insulin production, which maintains glucose homeostasis. Diabetes is characterized

Free access

Zhipeng Li, Zhaoshui Shangguan, Yijie Liu, Jihua Wang, Xuejun Li, Shuyu Yang and Suhuan Liu

pancreatic islet β-cell mass by immune attack, while T2D is characterized by insulin resistance and β-cell failure resulted from reductions in β-cell function and mass, they do share a common consequence, which is progressive β-cell failure due to apoptosis

Free access

Laura Marroquí, Alejandro Gonzalez, Patricia Ñeco, Ernesto Caballero-Garrido, Elaine Vieira, Cristina Ripoll, Angel Nadal and Ivan Quesada

Introduction A fine regulation of pancreatic β-cell function is essential for the control of plasma glucose homeostasis and nutrient metabolism. β-cell secretion and mass are dynamic features that adapt in the short and/or long term to the insulin

Free access

K Lindberg, S G Rønn, D Tornehave, H Richter, J A Hansen, J Rømer, M Jackerott and N Billestrup

Introduction Understanding the molecular mechanisms involved in pancreatic β-cell growth and differentiation is fundamental for developing novel strategies for the prevention and treatment of diabetes. This is the case for both type

Free access

Srividya Vasu, R Charlotte Moffett, Neville H McClenaghan and Peter R Flatt

Introduction In type 1 diabetes, proinflammatory cytokines such as interleukin 1β (IL1β), interferon γ (IFNγ) and tumour necrosis factor α (TNFα), released by autoimmune cells, are important mediators of pancreatic β-cell death ( Cnop et al . 2005

Free access

Seisuke Sato, Hitomi Imachi, Jingya Lyu, Yumi Miyai, Kensaku Fukunaga, Tao Dong, Tomohiro Ibata, Toshihiro Kobayashi, Takuo Yoshimoto, Fumi Kikuchi, Kazuko Yonezaki, Nao Yamaji, Hisakazu Iwama and Koji Murao

TNF-α played a role in impaired secretion of insulin, which frequently occurs in type 2 diabetes ( Donath et al. 2003 ). In pancreatic β-cells, TNF-α alone inhibited glucose-stimulated insulin secretion (GSIS) ( Zhang & Kim 1995 , Dunger et al

Restricted access

Shalinee Dhayal, Francesco P Zummo, Matthew W Anderson, Patricia Thomas, Hannah J Welters, Catherine Arden and Noel G Morgan

Introduction Chronic exposure of pancreatic β-cells to long-chain saturated fatty acids in vitro is associated with a phenomenon often referred to as ‘lipotoxicity’ in which the cells display secretory dysfunction and, ultimately, an

Free access

Laura de Miguel-Santos, Elisa Fernández-Millán, María Ángeles Martín, Fernando Escrivá and Carmen Álvarez

al . 1997 ), associated to the stimulation of β-cell proliferation due to locally increased pancreatic IGF-1 and islet IRS-2 production ( Martín et al . 2005 , Fernández et al . 2007 ). Nevertheless, food restriction continued after birth induced a

Free access

Yu-Feng Zhao, Li Wang, Dingjun Zha, Li Qiao, Lianjun Lu, Jun Yu, Ping Qu, Qiang Sun, Jianhua Qiu and Chen Chen

the GlaxoSmithKline chemical collection in 2006 ( Briscoe et al . 2006 ). In previous reports about FFARs actions on pancreatic β-cells, FFAs were commonly used as agonists of FFARs, but the effects of GW9508 on β-cell function were seldom reported