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Peng Zhang, Sheng Wang, Liang Wang, Bing Chen Shan, Hui Zhang, Fan Yang, Zhi Qiang Zhou, Xiao Wang, Ye Yuan and You Jia Xu

. 2015 ). Deficiency of estrogen accelerates bone resorption, resulting in type I osteoporosis. Furthermore, serum ferritin increases 2- to 3-fold during this period, due to the cessation of iron loss with decreased menstrual bleeding. Therefore, iron

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Ji Seon Park, Su Jung Bae, Sik-Won Choi, You Hwa Son, Sung Bum Park, Sang Dal Rhee, Hee Youn Kim, Won Hoon Jung, Seung Kyu Kang, Jin Hee Ahn, Seong Hwan Kim and Ki Young Kim

play a critical role in the age-related decrease in bone formation and increased risk of glucocorticoid-induced osteoporosis ( Cooper et al . 2002 ). In this study, we found the enhancing effects of KR-67500 and CBX on the BMP2-induced osteoblast

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Charit Taneja, Sakshi Gera, Se-Min Kim, Jameel Iqbal, Tony Yuen and Mone Zaidi

pituitary-metabolic circuits of physiological and medical significance ( Zaidi 2007 , Zaidi et al. 2018 a , b ), the link between serum FSH, osteoporosis and obesity lays a firm foundation for using a single FSH-blocking agent to prevent and

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R Rizzoli, JP Bonjour and SL Ferrari

Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue. At a given age, bone mass results from the amount of bone acquired during growth, i.e. the peak bone mass (Bonjour et al., 1991, Theintz et al. 1992) minus the age-related bone loss which particularly accelerates after menopause. The rate and magnitude of bone mass gain during the pubertal years and of bone loss in later life may markedly differ from one skeletal site to another, as well as from one individual to another. Bone mass gain is mainly related to increases in bone size, that is in bone external dimensions, with minimal changes in bone microarchitecture. In contrast, postmenopausal and age-related decreases in bone mass result from thinning of both cortices and trabeculae, from perforation and eventually disappearance of the latter, leading to significant alterations of the bone microarchitecture (Fig. 1).

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Tilman D Rachner, Lorenz C Hofbauer, Andy Göbel and Elena Tsourdi

Introduction Antiresorptive drugs constitute the mainstay of osteoporosis treatment to date. In particular, bisphosphonates have been the most commonly used drugs, with a proven efficacy to reduce the risk of vertebral, hip and non

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Gill Holdsworth, Scott J Roberts and Hua Zhu Ke

decline with advancing years ( Riggs & Melton 1986 , Boskey & Imbert 2017 ). Osteoporosis is a prevalent skeletal disorder characterised by reduced bone strength with an associated increased risk of fracture ( NIH Consensus Development Panel on

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Simona Mencej, Omar M E Albagha, Janez Preželj, Tomaž Kocjan and Janja Marc

-associated SNPs ( Knight 2003 ). Osteoporosis is a disease with a strong genetic component ( Ralston & Crombrugghe 2006 ) and its development is due to the persistent excess of osteoclastic bone resorption over osteoblastic bone formation ( Troen 2003 ). Genetic

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Siyi Zhu, Hongchen He, Chengfei Gao, Guojing Luo, Ying Xie, Haiming Wang, Li Tian, Xiang Chen, Xijie Yu and Chengqi He

formation and bone resorption, often resulting in postmenopausal osteoporosis ( Zaidi 2007 ). In postmenopausal osteoporosis, the bone-resorbing activity outpaces the bone-forming activity, which leads to a rapid loss of bone strength and an increased risk

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Xin-wei Chen, Ye-hong Li, Meng-jun Zhang, Zhou Chen, Dian-shan Ke, Ying Xue and Jian-ming Hou

Introduction Senile osteoporosis is a type of primary osteoporosis characterized by a substantial loss of bone mass, micro-architectural deterioration of bone tissue and reduction of bone quality ( Zhou et al. 2016 ). According to data from

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María Angeles Arevalo, María Santos-Galindo, Natalia Lagunas, Iñigo Azcoitia and Luis M Garcia-Segura

of breast cancer and osteoporosis, have been assessed in different experimental models of neural dysfunction. These include animal models of traumatic injury of the central nervous system and peripheral nerves, stroke, multiple sclerosis, Parkinson