Search Results

You are looking at 1 - 10 of 219 items for :

  • mitochondrial stress x
Clear All
Open access

Ting Xiao, Xiuci Liang, Hailan Liu, Feng Zhang, Wen Meng and Fang Hu

the stress response in the ER, mitochondrial stress is characterized by a mitochondrial unfolded protein response (UPR mt ) and initiation of a retrograde stress signaling pathway accompanied by impaired mitochondrial function and membrane potential

Free access

Hannah E Lapp, Andrew A Bartlett and Richard G Hunter

in stress-related disorders overlap with processes governed by mitochondrial function, suggesting a role for mitochondria in facilitating some of the effects of chronic stress on the body ( Picard & McEwen 2018 ). There is evidence from human and

Free access

Kelvin Yen, Changhan Lee, Hemal Mehta and Pinchas Cohen

dependent on the mitochondrial UPR ( Durieux et al . 2011 ). Another paper showed that mitochondria undergoing temperature stress release degraded protein peptides that trigger mitochondrial UPR ( Haynes et al . 2010 ). Humanin, the topic of this review

Free access

Xueyao Yin, Fenping Zheng, Qianqian Pan, Saifei Zhang, Dan Yu, Zhiye Xu and Hong Li

the pathogenesis of NASH have highlighted the central role of excessive activation of mitochondrial oxidative stress. To address this issue, we examined the effect of IHG on oxidative stress in vivo and in vitro . L02 cells exposed to PA and SHG

Open access

Hyon-Seung Yi, Joon Young Chang and Minho Shong

been the identification of the mitochondrial unfolded protein response (UPR mt ), a retrograde stress response induced by mitochondrial proteotoxic stress. The UPR mt was discovered in the late 1990s and is an area of increased scientific interest for

Free access

Keir Menzies and Johan Auwerx

modulate the acetylation status of the mitochondrial proteins and may therefore directly influence muscle metabolism and stress responses (reviewed in Pirinen et al . (2012) ). SIRT6 and SIRT7 are preferentially nuclear proteins. Of these nuclear proteins

Free access

Sehee Kim, Chanyang Kim and Seungjoon Park

, Chan 2004 ). Although the precise mechanisms leading to mitochondrial dysfunction and apoptotic cell death are still unclear, oxidative stress plays an important role in the depolarization of mitochondrial transmembrane potential (ΔΨ M ) and release of

Free access

Shilpa Thakur, Brianna Daley and Joanna Klubo-Gwiezdzinska

transcription factor that is induced by physiological stress. Metformin-mediated inhibition of mitochondrial respiration leads to oxidative stress, which in turn can stimulate ATF3 activity. ATF3 induction has been implicated in both the repression and

Restricted access

Ulas Ozkurede, Rishabh Kala, Cameron Johnson, Ziqian Shen, Richard A Miller and Gonzalo G Garcia

increased mitochondrial function and elevated levels of proteins involved in cellular stress resistance ( Gesing et al. 2011 a , Fang et al. 2013 , Pickering et al. 2015 , Dominick et al. 2017 ). These include elevation of direct DNA repair

Free access

Carmela Santangelo, Paola Matarrese, Roberta Masella, Maria Chiara Di Carlo, Angela Di Lillo, Beatrice Scazzocchio, Elio Vecci, Walter Malorni, Riccardo Perfetti and Emanuela Anastasi

al. 1998 a ). In vitro studies indicate that long-term exposure of β-cell to FFAs induces adverse effects on mitochondrial function, with elevated production of reactive oxygen species (ROS) and, consequently, increased oxidative stress leading to