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Ting Xiao, Xiuci Liang, Hailan Liu, Feng Zhang, Wen Meng, and Fang Hu

metabolic disorders and hepatic steatosis are yet to be fully elucidated. Recent studies have revealed that hepatic mTORC1-SREBP1 (sterol regulatory element-binding protein 1c) signaling plays a key role in regulating systemic hepatic lipid metabolism

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Oro Uchenunu, Michael Pollak, Ivan Topisirovic, and Laura Hulea

expression of PPP genes partly through SREBPs ( Fig. 2 ) ( Duvel et al . 2010 ), while PI3K inhibition has been shown to inhibit the PPP ( Wang et al . 2009 ). The MTORC1/RPS6KB1 signaling axis stimulates de novo pyrimidine synthesis via the

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Hyeon Young Park, Hye Suk Kang, and Seung-Soon Im

. 2011 ), whereas the induction of glutamine uptake and metabolism requires extracellular signal regulated kinase (ERK) function, driving T cell activation ( Carr et al . 2010 ). Glucose metabolism and mTORC1-HIF1α signaling are required for neutrophil

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Ayse Basak Engin, Atilla Engin, and Ipek Isik Gonul

). PI3K signaling promotes the activation of the pro-lipogenic factor sterol regulatory element-binding transcription factor 1 (SREBP1), however, mTORC1 is necessary for oncogenic/growth factor signaling to SREBP1 ( Düvel et al. 2010 ). Figure 2

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Yuka Toyoshima, Reiko Tokita, Yoichiro Ohne, Fumihiko Hakuno, Tadashi Noguchi, Shiro Minami, Hisanori Kato, and Shin-Ichiro Takahashi

enhanced insulin signals through the IR/IRS signaling pathway were transmitted to the downstream signaling pathway, we analyzed the activity of mTORC1 pathway that has very recently been shown to be important for inhibition of gluconeogenesis ( Houde et al

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Philip A Gruppuso and Jennifer A Sanders

pathway for cellular growth, which involves the mechanistic target of rapamycin (mTOR) ( Laplante & Sabatini 2012 , Albert & Hall 2015 ). mTOR participates in two signaling complexes, mTORC1 and mTORC2. mTORC1, the canonical target of the

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Emily Tubbs and Jennifer Rieusset

Terracciano L Heim MH Ruegg MA Hall MN 2012 Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c . Cell Metabolism 15 725 – 738 . ( doi:10.1016/j.cmet.2012.03.015 ) Hailey DW Rambold AS

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Colin R Jefcoate and Jinwoo Lee

Moldavski O Feltes M van der Welle RE Mydock-McGrane L Jiang X van Eijkeren RJ Davis OB Louie SM , et al . 2017 Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex . Science 355 1306 – 1311

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Liping Luo, Wanxiang Jiang, Hui Liu, Jicheng Bu, Ping Tang, Chongyangzi Du, Zhipeng Xu, Hairong Luo, Bilian Liu, Bo Xiao, Zhiguang Zhou, and Feng Liu

expressed from the maternally inherited allele in periphery tissues such as fat, muscle and liver tissues ( Lim et al . 2004 ). Recently, we have identified GRB10 as a negative-feedback regulator of the mTORC1 signaling pathway promotes lipolysis and

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Qin He, Dan Mei, Sha Sha, Shanshan Fan, Lin Wang, and Ming Dong


lipids, and then autophagy-related proteins were determined, including microtubule-associated protein 1 light chain 3 (LC3) and SQSTM1 (p62). Finally, 
ERK/mTOR signalling pathway was observed in order 
to reveal the potential molecular pathway underlying