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Ke-Hung Tsui, Li-Chuan Chung, Shyi-Wu Wang, Tsui-Hsia Feng, Phei-Lang Chang and Horng-Heng Juang

repressing the iron–sulfur cluster assembly proteins ISCU1/2 . Cell Metabolism 10 273 – 284 . ( doi:10.1016/j.cmet.2009.08.015 ). Chung LC Tsui KH Feng TH Lee SL Chang PL Juang HH 2011 Curcumin provides potential protection against the

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Edward T Bagu and Manuela M Santos

GATA (FOG) modulate the tissue-specific transcription of other genes involved in the metabolism of iron, in particular: GATA-1 is a transcriptional enhancer of hemochromatosis ( HFE ; Mura et al . 2004 ) and erythropoietin receptor ( EPOR ; Chiba et

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Xin-wei Chen, Ye-hong Li, Meng-jun Zhang, Zhou Chen, Dian-shan Ke, Ying Xue and Jian-ming Hou

existing drugs to recover bone mass, the presence of various side effects ( Ke et al. 2016 ) or high cost. Therefore, the identification of safer and more effective anti-osteoporosis agents is required. Lactoferrin (LF) is a non-heme iron

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Gilberto Paz-Filho, Claudio Alberto Mastronardi, Brian J Parker, Ainy Khan, Antonio Inserra, Klaus I Matthaei, Monika Ehrhart-Bornstein, Stefan Bornstein, Ma-Li Wong and Julio Licinio

necessarily in the same direction, such as i) drug and xenobiotic metabolism by cytochrome P450; ii) PPAR signaling pathway; iii) retinol, arachidonic/organic acid, and monocarboxylic acid metabolic processes; iv) heme, pyrrole, and iron binding; v

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Matthew L Rise, Susan E Douglas, Dionne Sakhrani, Jason Williams, K Vanya Ewart, Marlies Rise, William S Davidson, Ben F Koop and Robert H Devlin

trout sequences), or paralogous sequences. Many of the microarray-identified hepatic transcripts responsive to GH transgenesis with and without rationing are involved in iron homeostasis, energy metabolism, mitochondrial function, cellular

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Peng Zhang, Sheng Wang, Liang Wang, Bing Chen Shan, Hui Zhang, Fan Yang, Zhi Qiang Zhou, Xiao Wang, Ye Yuan and You Jia Xu

Introduction Hepcidin is a small peptide hormone that is synthesized and secreted by the liver and regulates iron metabolism ( Zhao et al . 2013 ). Hepcidin acts by binding to the ferroportin iron exporter, which triggers its internalization

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Jakob Bondo Hansen, Laila Romagueira Bichara Dos Santos, Ying Liu, Kacey J Prentice, Frederik Teudt, Morten Tonnesen, Jean-Christophe Jonas, Michael B Wheeler and Thomas Mandrup-Poulsen

GLT specifically alters the iron metabolism in beta-cells both in vivo and in vitro resulting in apoptosis. GLT induced Dmt1 and Trfr mRNA upregulation in beta-cells, and this was associated with increased iron uptake, increased intracellular

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Xin Jiang, Heyang Wang, Wencai Shi, Zhilei Shen, Hui Shen and Min Li

iron overload ( Mitsuyoshi et al . 2009 ). It was also reported in clinical studies that accumulation of hepatic iron might impair the insulin effect by reducing hepatic insulin extraction and metabolism and decreasing glucose uptake in muscle

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S Lortz, S Schröter, V Stückemann, I Mehmeti and S Lenzen

deprivation, a number of signaling pathways involved in systemic iron transport, cellular iron supply, and metabolism are activated. Therefore, the effects of temporary hypoxia on Dmt1 isoform expression were analyzed. Incubation of RINm5F cells for 6 h at 1

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D L Johnson, A J Conley and L L Martin

metabolism. Among eukaryotic enzymes, the so-called steroidogeneic P450s generally metabolize a narrower range of substrates than other members of the superfamily. Cytochrome P450s expressed in the adrenal cortex and gonads catalyse critical steps in