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James E P Brown, David J Onyango, Manjunath Ramanjaneya, Alex C Conner, Snehal T Patel, Simon J Dunmore and Harpal S Randeva

elucidated. This study therefore aimed to clarify the actions of visfatin in the pancreatic β-cell by investigating not only its effects on insulin secretion and insulin receptor phosphorylation, but also its regulation of the expression of a panel of

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Hongmei Lang, Zhihua Ai, Zhiqing You, Yong Wan, Wei Guo, Jie Xiao and Xiaolan Jin

, Zhang et al . 2015 ). Type 2 diabetes (T2D) is characterized by reduced insulin secretion from pancreatic β-cells and insulin resistance at the target cells, which result in increased blood glucose levels ( Kahn 2001 ). It has been reported that

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Magdalene O Wilson, Kathleen T Scougall, Jarupa Ratanamart, Elizabeth A McIntyre and James A M Shaw

-targeted gene therapy for conditions including haemophilia without reported adverse effects ( Gene Therapy Clinical Trials online database 2004 ). We and others have demonstrated constitutive secretion of fully processed human insulin for up to 8 weeks

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Pamela Petrocchi-Passeri, Cheryl Cero, Alessandro Cutarelli, Claudio Frank, Cinzia Severini, Alessandro Bartolomucci and Roberta Possenti

Introduction Impaired insulin secretion and insulin resistance play major roles in the development of type 2 diabetes (T2D). The most important regulators of insulin secretion are plasma nutrients, among which glucose is the most effective; however

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Yu-Feng Zhao, Li Wang, Dingjun Zha, Li Qiao, Lianjun Lu, Jun Yu, Ping Qu, Qiang Sun, Jianhua Qiu and Chen Chen

. There are only reports showing that GW9508 potentiated glucose-stimulated insulin secretion (GSIS) in insulinoma cell lines such as MIN6 cells and INS-1E cells ( Briscoe et al . 2006 , Yang et al . 2010 ). And it was shown that GW9508 does not

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Quinn Dufurrena, Nils Bäck, Richard Mains, Louis Hodgson, Herbert Tanowitz, Prashant Mandela, Betty Eipper and Regina Kuliawat

granules is followed by slower, longer-lasting secretion of the reserve pool ( Straub & Sharp 2002 , Rorsman & Braun 2013 ). Different secretagogues selectively stimulate the release of insulin from the RRP or the reserve pool. Based on studies with

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Jessica Sabourin and Florent Allagnat

Introduction Insulin secretion is driven by electrical activity and oscillations of intracellular Ca 2+ concentration ([Ca 2+ ] i ) in pancreatic β-cells. The main driver of insulin secretion is plasma glucose; glucose metabolism produces ATP

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Joong Kwan Kim, Yongchul Lim, Jung Ok Lee, Young-Sun Lee, Nam Hee Won, Hyun Kim and Hyeon Soo Kim

these studies indicate that PRMT4 plays a critical role in transcriptional regulation as a co-activator. Insulin biosynthesis and secretion in pancreatic β cells play central roles in the control of glucose homeostasis in mammals. Insulin release is

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Marloes Dekker Nitert, Cecilia L F Nagorny, Anna Wendt, Lena Eliasson and Hindrik Mulder

. This sets off a depolarisation of the plasma membrane, which opens the voltage-gated calcium channels. The subsequent increase in intracellular calcium [Ca 2 + ] i initiates the secretion of insulin granules from the β-cells. The voltage-gated calcium

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Patrizia Morera, Loredana Basiricò, Kenji Hosoda and Umberto Bernabucci

, leading to an overall decrease in fat deposition ( Ailhaud 2006 , Lafontan & Viguerie 2006 ). In addition to its insulin-sensitising effect, adiponectin may modify glucose metabolism by stimulating pancreatic insulin secretion ( Rabe et al . 2008 ). Few