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Jenica H Kakadia
Jenica H Kakadia
Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
Children's Health Research Institute, London, Ontario, Canada
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Children's Health Research Institute, London, Ontario, Canada
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Muhammad U Khalid
Muhammad U Khalid
Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
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Ilka U Heinemann
Ilka U Heinemann
Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
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Victor K Han
Victor K Han
Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
Children's Health Research Institute, London, Ontario, Canada
Department of Pediatrics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
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Children's Health Research Institute, London, Ontario, Canada
Department of Pediatrics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
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. 2021 ). However, the mechanisms by which glucose deprivation alters IGFBP-1 phosphorylation is currently unknown. We hypothesized that AMPK (5′adenosine monophosphate-activated protein kinase), a key energy sensor, is activated by glucose deprivation
Yuka Toyoshima
Yuka Toyoshima
Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
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Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
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Reiko Tokita
Reiko Tokita
Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
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Yoichiro Ohne
Yoichiro Ohne
Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
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Fumihiko Hakuno
Fumihiko Hakuno
Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
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Tadashi Noguchi
Tadashi Noguchi
Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
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Shiro Minami
Shiro Minami
Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
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Hisanori Kato
Hisanori Kato
Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
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Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
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Shin-Ichiro Takahashi
Shin-Ichiro Takahashi
Departments of, Applied Biological Chemistry, Animal Sciences, The Chubu Institute for Advanced Studies, Department of Bioregulation, Organization for Interdisciplinary Research Projects, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
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of insulin on glucose uptake in the muscle was more prominent in PF-fed rats than in those fed with a 12% casein diet (12C) as a control diet. These results led us to conclude that protein deprivation causes the sensitization of IRS1 to IR tyrosine
Yan Zheng
Yan Zheng
Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, New Mexico, USA
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Kevin D Houston
Kevin D Houston
Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, New Mexico, USA
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pancreatic cells ( Johnston 1999 ). D-glucose deprivation can also induce the expression of genes such as heme oxygenase-1 ( Chang et al. 2002 ) and interleukin 6 ( Choi et al. 2013 ). Furthermore, in D-glucose-deprived cells, AMP-activated protein kinase
Inge Seim
Inge Seim
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
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Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
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Amy A Lubik
Amy A Lubik
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
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Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
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Melanie L Lehman
Melanie L Lehman
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
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Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
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Nadine Tomlinson
Nadine Tomlinson
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
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Eliza J Whiteside
Eliza J Whiteside
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
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Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
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Adrian C Herington
Adrian C Herington
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
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Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
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Colleen C Nelson
Colleen C Nelson
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
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Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
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Lisa K Chopin
Lisa K Chopin
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
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Ghrelin Research Group, Australian Prostate Cancer Research Centre – Queensland, The Vancouver Prostate Centre, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia
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with prostate cancer progression, androgen deprivation therapy, the standard treatment for advanced prostate cancer, frequently gives rise to metabolic syndrome and insulin resistance, with hyperinsulinaemia, elevated fasting blood glucose and elevated
CP Turner
CP Turner
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MR Blackburn
MR Blackburn
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SA Rivkees
SA Rivkees
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The cellular mechanisms that lead to neuronal death following glucose deprivation are not known, although it is recognized that hypoglycemia can lead to perturbations in intracellular calcium ([Ca2+]i) levels. Recently, activation of A1 adenosine receptors (A1AR) has been shown to alter [Ca2+]i and promote neuronal death. Thus, we examined if A1AR activation contributes to hypoglycemia-induced neuronal injury using rat cortical neurons. First, we observed that hypoglycemia was associated with large increases in neuronal adenosine release. Next, decreased neuronal viability was seen with progressive reduction in glucose concentration (25, 6, 3, 0.75 and 0 mM). Using the calcium-sensitive dye, Fluo-3, we observed both acute and long-term changes in relative [Ca2+]i during hypoglycemic conditions. Demonstrating a role for adenosine in this process, both the loss in neuronal viability and the early changes in [Ca2+]i were reversed by treatment with A1AR antagonists (8-cyclopentyl, 1,3-dipropylxanthine; 9-chloro-2-(2-furyl)(1,2,4)-triazolo(1,5-c)quinazolin-5-amine; and N-cyclopentyl-9-methyladenine). We also found that hypoglycemia induced the expression of the pro-apoptotic enzyme, caspase-3, and that A1AR antagonism reversed hypoglycemia-induced caspase-3 activity. Collectively, these data show that hypoglycemia induces A1ARs activation leading to alterations in [Ca2+]i, which plays a prominent role in leading to hypoglycemia-induced neuronal death.
Federica Morani
Federica Morani
Laboratory of Molecular Pathology and Nanobioimaging, Unit of Clinical Endocrinology, Unit of Oncology, Department of Health Sciences
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Suratchanee Phadngam
Suratchanee Phadngam
Laboratory of Molecular Pathology and Nanobioimaging, Unit of Clinical Endocrinology, Unit of Oncology, Department of Health Sciences
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Carlo Follo
Carlo Follo
Laboratory of Molecular Pathology and Nanobioimaging, Unit of Clinical Endocrinology, Unit of Oncology, Department of Health Sciences
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Rossella Titone
Rossella Titone
Laboratory of Molecular Pathology and Nanobioimaging, Unit of Clinical Endocrinology, Unit of Oncology, Department of Health Sciences
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Gianluca Aimaretti
Gianluca Aimaretti
Laboratory of Molecular Pathology and Nanobioimaging, Unit of Clinical Endocrinology, Unit of Oncology, Department of Health Sciences
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Alessandra Galetto
Alessandra Galetto
Laboratory of Molecular Pathology and Nanobioimaging, Unit of Clinical Endocrinology, Unit of Oncology, Department of Health Sciences
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Oscar Alabiso
Oscar Alabiso
Laboratory of Molecular Pathology and Nanobioimaging, Unit of Clinical Endocrinology, Unit of Oncology, Department of Health Sciences
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Ciro Isidoro
Ciro Isidoro
Laboratory of Molecular Pathology and Nanobioimaging, Unit of Clinical Endocrinology, Unit of Oncology, Department of Health Sciences
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%) and l -glutamine (1%). All culture reagents were purchased from Sigma–Aldrich. For studies on glucose deprivation, the cells were incubated in a glucose-free medium (R1383 and D5030, Sigma–Aldrich). For the experiments, growing cells were plated on
Juan Zhang
Juan Zhang
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Yunting Zhou
Yunting Zhou
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Cheng Chen
Cheng Chen
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Feiyuan Yu
Feiyuan Yu
Department of Pediatrics, Department of Molecular Pathology, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China
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Yun Wang
Yun Wang
Department of Pediatrics, Department of Molecular Pathology, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China
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Jiang Gu
Jiang Gu
Department of Pediatrics, Department of Molecular Pathology, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China
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Lian Ma
Lian Ma
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Guyu Ho
Guyu Ho
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kinase (AMPK) is a cellular energy sensor, activated under states of low cellular energy such as glucose deprivation ( Kahn et al . 2005 , Hardie et al . 2006 ). AMPK is also postulated to mediate hypothalamic glucose sensing. For instance, i
Yajie Guo
Yajie Guo
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Junjie Yu
Junjie Yu
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Chunxia Wang
Chunxia Wang
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Kai Li
Kai Li
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Bin Liu
Bin Liu
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Ying Du
Ying Du
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Fei Xiao
Fei Xiao
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Shanghai Chen
Shanghai Chen
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Feifan Guo
Feifan Guo
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, People’s Republic of China
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-binding protein 1c ( Srebp1c ) and plays an important role in regulating fatty acid metabolism ( Wang et al . 2014 ). Our previous study indicated that dietary deprivation of leucine suppresses lipid accumulation in the liver by downregulating the expression of
Sehee Kim
Sehee Kim
Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Korea
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Chanyang Kim
Chanyang Kim
Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Korea
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Seungjoon Park
Seungjoon Park
Department of Pharmacology and Medical Research Center for Bioreaction to ROS and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea
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. 2002 ). We have reported that AG blocks oxygen–glucose deprivation-induced apoptosis by preventing mitochondrial depolarization (loss of ΔΨ M ) ( Chung et al. 2007 ). Therefore, we examined the effect of ghrelin gene products on ΔΨ M using JC-1
Inagadapa J N Padmavathi
Inagadapa J N Padmavathi
Division of Endocrinology and Metabolism, National Centre for Laboratory Animal Sciences, National Institute of Nutrition, Jamai Osmania PO, Hyderabad 500 007, India
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Kalashikam Rajender Rao
Kalashikam Rajender Rao
Division of Endocrinology and Metabolism, National Centre for Laboratory Animal Sciences, National Institute of Nutrition, Jamai Osmania PO, Hyderabad 500 007, India
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Manchala Raghunath
Manchala Raghunath
Division of Endocrinology and Metabolism, National Centre for Laboratory Animal Sciences, National Institute of Nutrition, Jamai Osmania PO, Hyderabad 500 007, India
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response to oral glucose challenge ( Berney et al . 1997 , Reusens & Remacle 2001 ). We showed earlier that maternal micronutrient restriction increased body fat% especially the central adiposity, impaired plasma lipids, altered glucose tolerance
