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Hiroyuki Kaiya, Kenji Kangawa and Mikiya Miyazato

The discovery of growth hormone secretagogue receptor and its endogenous ligand, ghrelin, and ghrelin gene-derived peptides Most receptors for peptide hormones are G-protein-coupled receptors (GPCRs). There are still unidentified endogenous ligands

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Nils Wierup, Frank Sundler and R Scott Heller

novel islet cell type, the islet ghrelin cell, has been presented and confirmed by several laboratories. This cell is the fifth cell type to be described in the adult human islets. Further, it is the seventh islet cell with known hormonal content when

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Farhana Naznin, Koji Toshinai, T M Zaved Waise, Tadashi Okada, Hideyuki Sakoda and Masamitsu Nakazato

nodose ganglion, making one projection to the NTS and the other to peripheral organs. Vagal afferent neurons express receptors for gut peptides such as ghrelin, cholecystokinin and glucagon-like peptide 1 that regulate feeding and energy homeostasis

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Inge Seim, Amy A Lubik, Melanie L Lehman, Nadine Tomlinson, Eliza J Whiteside, Adrian C Herington, Colleen C Nelson and Lisa K Chopin

Introduction The 28 amino acid hormone ghrelin has emerged as a multifunctional peptide hormone with actions beyond its roles in GH secretion, appetite regulation and energy balance ( Kojima et al . 1999 , Wren et al . 2000 , Nakazato et al

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Maggie C Evans and Greg M Anderson

axis, we know from both animal and clinical studies that certain nutritional signals, such as leptin, insulin and ghrelin, exert a more critical influence over GNRH/LH pulsatility (and thus fertility) than others and that in at least some cases their

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Luis Varela, María J Vázquez, Fernando Cordido, Rubén Nogueiras, Antonio Vidal-Puig, Carlos Diéguez and Miguel López

Ghrelin: a stomach-derived peptide modulating energy balance A large degree of attention has surrounded the prospect of ghrelin becoming a key factor in the fight against obesity. This 28 amino acid peptide hormone, with orexigenic properties

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Rong-Ying Li, Xue-Song Li, Li Shao, Zhi-yuan Wu, Wen-Hua Du, Sheng-Xian Li, Shuang-xia Zhao, Ke-min Chen, Ming-Dao Chen and Huai-Dong Song

Introduction Ghrelin, a 28 amino acid peptide, is originally identified in the rat stomach as an endogenous ligand for the GH secretagogue receptor ( Kojima et al . 1999 ). It strongly stimulates GH release in a dose-dependent manner in animals and

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Clemens Wagner, S Roy Caplan and Gloria S Tannenbaum

accomplished by introducing a feedback loop of GH on SRIF neurons in the hypothalamus that synthesize the GH receptors (GH-R; see Wagner et al . (1998) ). The recent discovery of the hormone ghrelin, which represents the endogenous ligand for the GH

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H Douglas Falls, Brian D Dayton, Dennis G Fry, Christopher A Ogiela, Verlyn G Schaefer, Sevan Brodjian, Regina M Reilly, Christine A Collins and Wiweka Kaszubska

, indicating that they probably act via different mechanisms ( Smith et al. 1997 , Ghigo et al. 2001 ). Recently, a natural ligand for GHS-R was identified. Ghrelin is a 28-amino acid, octanoylated peptide secreted primarily by the upper intestinal

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Sehee Kim, Chanyang Kim and Seungjoon Park

Introduction Two major molecular forms of ghrelin are found in plasma, acylated ghrelin (AG) and unacylated ghrelin (UAG) ( Hosoda et al. 2000 ). AG is a 28-amino acid peptide, which shows a unique posttranslational modification of O - n