/unfold any genomic locus, as recently revealed by Hi-C technique and Monte Carlo simulations ( Lieberman-Aiden et al . 2009 ). The organization of chromatin on a genome scale deeply affects gene transcription regulation ( Li et al . 2007 , Ernst et al
L L Burger, D J Haisenleder, A C Dalkin and J C Marshall
regulate either positively or negatively LH and FSH synthesis and secretion. The aims of this review are to present the transcriptional regulation of the gonadotropin subunit genes in a physiologic setting and examine the mechanisms that drive those changes
Hiroshi Ishikawa, Makio Shozu, Masahiko Okada, Mai Inukai, Bo Zhang, Keiichi Kato, Tadayuki Kasai and Masaki Inoue
cause synchronized down-regulation of a cohort of genes sharing potential binding sites for EGR1, allowing accelerated proliferation of leiomyoma cells. EGR1 plays diverse roles in the physiology and pathology of numerous organs and cells, including cell
V X Jin, H Sun, T T Pohar, S Liyanarachchi, S K Palaniswamy, T H-M Huang and R V Davuluri
as alternative binding sites ( Gruber et al. 2004 ). Since ERs are key regulators of growth, differentiation and metabolism in multiple organs, the characterization of transcriptional regulation of their target genes is of significant
Edson F Nogueira, Claudia A Vargas, Mélissa Otis, Nicole Gallo-Payet, Wendy B Bollag and William E Rainey
, FOSB, NR4A3, and EGR4. Figure 1 Microarray analysis of human H295R cells after treatment for 1 h with 10 nM Ang-II versus basal (panel A). B shows confirmation with qPCR of gene up-regulation of the top five genes, which act as transcription factors
R Gruemmer, L Klein-Hitpaß and J Neulen
culture medium conditioned by human granulosa cells. Gene expression was evaluated by microarray technology, and transcriptomes of the differently treated endothelial cells were compared with regard to the regulation of angiogenic and antiangiogenic genes
Daniil V Popov, Evgeny A Lysenko, Tatiana F Vepkhvadze, Nadia S Kurochkina, Pavel A Maknovskii and Olga L Vinogradova
for regulation of activity-induced PGC-1 α gene expression from the canonical promoter ( Zhang et al . 2014 ). Several groups ( Norrbom et al . 2011 , Ydfors et al . 2013 , Popov et al . 2014 ) have shown that in human skeletal muscle, acute
L Appelbaum, D Vallone, A Anzulovich, L Ziv, M Tom, N S Foulkes and Y Gothilf
analyses of aanat1 and aanat2 regulation by light, the circadian clock and its components were performed. The results indicate differential regulation of expression of these two related genes, highlighting that a combination of mechanisms fine
Jacques Drouin
Introduction The POMC gene has proven to be incredibly informative to study various aspects of gene regulation. Indeed, its restricted expression in two pituitary cell lineages provided the system to identify cell-restricted transcription
Anke Schennink, Josephine F Trott, Rodrigo Manjarin, Danielle G Lemay, Bradley A Freking and Russell C Hovey
date of 5′ PRLR gene regulation across tissues for any species. Among the nine new first- PRLR exons we identified, we found that expression of one first exon, pE1.3, was primarily expressed in the kidney cortex and small intestine, where a homologous
