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Horng-Yih Ou, Hung-Tsung Wu, Feng-Hwa Lu, Yu-Chu Su, Hao-Chang Hung, Jin-Shang Wu, Yi-Ching Yang, Chao-Liang Wu and Chih-Jen Chang

carcinoma. However, there is still no effective treatment for hepatic steatosis, and life style modification remains the best therapeutic option ( Ferre & Foufelle 2010 ). Free fatty acid receptor 1 (FFAR1), also named G-protein-coupled receptor 40, is a

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Guojun Shi, Chen Sun, Weiqiong Gu, Minglan Yang, Xiaofang Zhang, Nan Zhai, Yan Lu, Zhijian Zhang, Peishun Shou, Zhiguo Zhang and Guang Ning

). In 2003, two G-protein-coupled receptors (GPCRs), free fatty acid receptor 2 (FFAR2, also known as GPR43) and FFAR3 (also known as GPR41), were first identified as receptors for SCFAs ( Brown et al . 2003 , Le Poul et al . 2003 , Nilsson et al

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Carmela Santangelo, Paola Matarrese, Roberta Masella, Maria Chiara Di Carlo, Angela Di Lillo, Beatrice Scazzocchio, Elio Vecci, Walter Malorni, Riccardo Perfetti and Emanuela Anastasi

hyperlipidemia contribute to β-cells dysfunction and a decrease of β-cell mass ( Dickson & Rhodes 2004 ). Free fatty acids (FFAs), at physiological concentrations, modulate the process of basal and glucose-induced insulin secretion in pancreatic β

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M J Watt, R J Southgate, A G Holmes and M A Febbraio

. 1999 ) and prolonged exercise ( Terada et al. 2002 , Pilegaard et al. 2003 ). In these situations, plasma free fatty acid (FFA) availability is increased dramatically, which provides a clue to a potential mechanism through which PGC1α gene

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R M Señarís, M D Lewis, F Lago, F Domínguez, M F Scanlon and C Diéguez

ABSTRACT

The effects of free fatty acids on somatostatin secretion, content and mRNA levels in fetal rat hypothalamic and cortical cell cultures were investigated. Somatostatin secretion and content were quantified by radioimmunoassay. Somatostatin mRNA levels were measured by Northern blot hybridization using a cRNA probe. Treatment with either caprylic acid (5×10-3 m) or oleic acid (5× 10-5 m) for 90 min inhibited basal somatostatin secretion in both hypothalamic and cortical cell cultures. In addition, the increase in somatostatin secretion induced by incubation with veratridine (10-4 m) or carbachol (10-4 m) for 90 min was significantly reduced by the addition of caprylic acid, but somatostatin release stimulated by 5·6×10-2 m KCl was not affected. Furthermore, treatment with these free fatty acids for 90 min markedly decreased somatostatin mRNA levels in both types of neurone culture. These inhibitory effects were transient, being observed after 90 min, but not after 5 h. These results support the probability that there is a role for free fatty acids in the regulation of somatostatin mRNA levels and somatostatin secretion in both hypothalamic and cortical cell cultures.

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Lan Xu, Wenting Wang, Xinyue Zhang, Hanni Ke, Yingying Qin, Li You, Weiping Li, Gang Lu, Wai-Yee Chan, Peter C K Leung, Shidou Zhao and Zi-Jiang Chen

miscarriages ( Shah et al. 2011 , Mitchell & Fantasia 2016 ). Although it has been recognized that a variety of risk factors such as leptin, TNF-α and free fatty acids (FFAs) are involved in the pathogenesis of obesity-related disorders ( Uysal et al. 1997

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Yanxia Tang and GuoDong Li

increased plasma levels of free fatty acids (FFAs) resulting from lack of appropriate suppression of adipocyte lipolysis due to insulin resistance and deficiency ( Reaven 1988 , Imrie et al . 2010 ). Furthermore, circulating levels of FFAs are usually

Open access

Bo Li, Zhiguo Zhang, Huizhi Zhang, Kai Quan, Yan Lu, Dongsheng Cai and Guang Ning

standard cages and conditions (at 20–24 °C, relative humidity 50–60%, with a 12 h light:12 h darkness cycle). Serum free FA (FFA) was measured using the Non-esterified Fatty Acids (NEFA) Commercial Kit (Wako, Osaka, Japan). The animal protocol was reviewed

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Ying Zhang, Mingtong Xu, Shaoling Zhang, Li Yan, Chuan Yang, Wensheng Lu, Yan Li and Hua Cheng

Introduction Type 2 diabetes (T2D) is tightly linked to obesity, which is characterized by hyperlipidemia and elevated circulating free fatty acids (FFAs; Kashyap et al. 2003 , Moller & Kaufman 2005 ). Long-chain FFAs have

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Raghunath Chatterjee, Paramita Bhattacharya, Oksana Gavrilova, Kimberly Glass, Jaideep Moitra, Max Myakishev, Stephanie Pack, William Jou, Lionel Feigenbaum, Michael Eckhaus and Charles Vinson

blood or serum using a Glucometer Elite (Bayer). Serum insulin, leptin, adiponectin, and resistin were measured by RIA (Linco, St. Charles, MO, USA). Serum triglycerides (Thermo Electron, Louisville, CO, USA. # 2780-400H) and free fatty acids (Roche