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Rebecca H Ritchie Heart Failure Pharmacology, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia
Central Clinical School, Monash University, Melbourne, Victoria, Australia

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Eser J Zerenturk Lipid Metabolism & Cardiometabolic Disease Laboratory, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia

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Darnel Prakoso Heart Failure Pharmacology, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia
School of Biosciences, The University of Melbourne, Parkville, Victoria, Australia

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Anna C Calkin Central Clinical School, Monash University, Melbourne, Victoria, Australia
Lipid Metabolism & Cardiometabolic Disease Laboratory, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia

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first observed in the 1970s after post-mortem studies of four individuals exhibiting concomitant diabetes and heart failure, in the absence of hypertension, coronary artery disease (CAD) or other likely causal factors ( Rubler et al . 1972 , Regan et

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-16-0249
Volume/Issue:
Volume 58: Issue 4
Free access
Alvaro Moreira Department of Pediatrics, University of Texas Health Science Center-San Antonio, San Antonio, Texas, USA

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Samuel Kahlenberg Department of Pediatrics, University of Texas Health Science Center-San Antonio, San Antonio, Texas, USA

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Peter Hornsby Department of Physiology, Texas Research Park Campus, Barshop Institute for Longevity and Aging Studies, San Antonio, Texas, USA

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utility of MSCs as therapeutic agents for an array of medical conditions. The aim of this review is to provide a concise summary of the existing literature evaluating MSCs as novel therapeutic agents for diabetes mellitus. Additionally, this focused

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-17-0117
Volume/Issue:
Volume 59: Issue 3
Free access
Mohamed H Noureldein Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine and Medical Center, American University of Beirut

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Sara Bitar Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine and Medical Center, American University of Beirut

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Natalie Youssef Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine and Medical Center, American University of Beirut

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Sami Azar American University of Beirut Medical Center, Department of Internal Medicine, Beirut, Lebanon
American University of Beirut Diabetes, Beirut, Lebanon

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Assaad A Eid Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine and Medical Center, American University of Beirut
American University of Beirut Diabetes, Beirut, Lebanon

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Introduction Type 2 diabetes mellitus (T2DM) has a wide range of etiologies, intricate pathogenesis and predisposes for various serious micro- and macro-vascular complications. Diabetes mellitus is strongly associated with disturbance of gut

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-19-0132
Volume/Issue:
Volume 64: Issue 1
Restricted access
Afreen Idris Shariff Division of Endocrinology, Metabolism and Nutrition, Duke University School of Medicine, Durham, North Carolina, USA

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Sohail Syed Virginia Commonwealth University, Richmond, Virginia, USA

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Rebecca A Shelby Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA

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Jeremy Force Division of Medical Oncology, Duke University School of Medicine, Durham, North Carolina, USA

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Jeffrey Melson Clarke Division of Medical Oncology, Duke University School of Medicine, Durham, North Carolina, USA

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David D’Alessio Division of Endocrinology, Metabolism and Nutrition, Duke University School of Medicine, Durham, North Carolina, USA

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Leonor Corsino Division of Endocrinology, Metabolism and Nutrition, Duke University School of Medicine, Durham, North Carolina, USA

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both and have been associated with the development of both T1DM and T2DM ( Yang & Yee 2012 ). It is important to note that a concurrent diagnosis of diabetes is associated with increased risk of all-cause mortality in patients with cancer. A large

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-18-0002
Volume/Issue:
Volume 62: Issue 2
Free access
Zhipeng Li Xiamen Diabetes Institute, Central Laboratory, Division of Gastroenterology, Division of Endocrinology and Diabetes, Beijing University of Chinese Medicine
Xiamen Diabetes Institute, Central Laboratory, Division of Gastroenterology, Division of Endocrinology and Diabetes, Beijing University of Chinese Medicine

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Zhaoshui Shangguan Xiamen Diabetes Institute, Central Laboratory, Division of Gastroenterology, Division of Endocrinology and Diabetes, Beijing University of Chinese Medicine

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Yijie Liu Xiamen Diabetes Institute, Central Laboratory, Division of Gastroenterology, Division of Endocrinology and Diabetes, Beijing University of Chinese Medicine

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Jihua Wang Xiamen Diabetes Institute, Central Laboratory, Division of Gastroenterology, Division of Endocrinology and Diabetes, Beijing University of Chinese Medicine

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Xuejun Li Xiamen Diabetes Institute, Central Laboratory, Division of Gastroenterology, Division of Endocrinology and Diabetes, Beijing University of Chinese Medicine
Xiamen Diabetes Institute, Central Laboratory, Division of Gastroenterology, Division of Endocrinology and Diabetes, Beijing University of Chinese Medicine

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Shuyu Yang Xiamen Diabetes Institute, Central Laboratory, Division of Gastroenterology, Division of Endocrinology and Diabetes, Beijing University of Chinese Medicine
Xiamen Diabetes Institute, Central Laboratory, Division of Gastroenterology, Division of Endocrinology and Diabetes, Beijing University of Chinese Medicine

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Suhuan Liu Xiamen Diabetes Institute, Central Laboratory, Division of Gastroenterology, Division of Endocrinology and Diabetes, Beijing University of Chinese Medicine
Xiamen Diabetes Institute, Central Laboratory, Division of Gastroenterology, Division of Endocrinology and Diabetes, Beijing University of Chinese Medicine

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Introduction The incidence of diabetes has been increasing at an alarming rate in the past decade and is now becoming a major epidemic in China and worldwide ( Xu et al . 2013 ). Although type 1 diabetes mellitus (T1D) is characterized by loss of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-13-0302
Volume/Issue:
Volume 53: Issue 1
Free access
Haihua Yang Division of Endocrinology, Zhengzhou Children’s Hospital, Zhengzhou, Henan, China

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Linghai Yang Department of Pharmacology, University of Washington, Seattle, Washington, USA

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probably not in all T2D patients ( Samuel et al . 2009 ). Increased expression of G6Pase in the liver is also associated with diabetes ( Haber et al . 1995 , van Schaftingen & Gerin 2002 ). PGC1α is a transcriptional coactivator that plays a central role

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-15-0316
Volume/Issue:
Volume 57: Issue 2
Free access
Christopher E Wall Gene Expression Laboratory, Salk Institute, La Jolla, California, USA
Biomedical Sciences Graduate Program, UC San Diego, La Jolla, California, USA

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Ruth T Yu Gene Expression Laboratory, Salk Institute, La Jolla, California, USA

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Anne R Atkins Gene Expression Laboratory, Salk Institute, La Jolla, California, USA

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Michael Downes Gene Expression Laboratory, Salk Institute, La Jolla, California, USA

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Ronald M Evans Gene Expression Laboratory, Salk Institute, La Jolla, California, USA
Howard Hughes Medical Institute, Salk Institute, La Jolla, California, USA

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, hypercholesterolemia, and diabetes ( Knowler et al . 2002 , Shin et al . 2013 ). Even a small increase in daily physical activity can improve muscle fitness, promote resistance to diet-induced obesity, and reduce systemic inflammation ( Warburton et al . 2006

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-16-0073
Volume/Issue:
Volume 57: Issue 1
Free access
Kira Meyerovich ULB Center for Diabetes Research, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Fernanda Ortis Department of Cell and Developmental Biology, Universidade de São Paulo, São Paulo, Brazil

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Florent Allagnat Department of Vascular Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland

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Alessandra K Cardozo ULB Center for Diabetes Research, Université Libre de Bruxelles (ULB), Brussels, Belgium

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role of the UPR in the context of β-cell demise leading to diabetes ( Brozzi & Eizirik 2016 , Hasnain et al. 2016 ). This article focuses on (1) the signal transduction pathways involved in the UPR and their connections to inflammation, (2) the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-15-0306
Volume/Issue:
Volume 57: Issue 1
Free access
Jakob Bondo Hansen Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Laila Romagueira Bichara Dos Santos Université Catholique de Louvain, Institute of Experimental and Clinical Research, Pole of Endocrinology, Diabetes and Nutrition, Brussels, Belgium

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Ying Liu Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Kacey J Prentice Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Frederik Teudt Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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Morten Tonnesen Department of Diabetes Complications Biology & Pharmacology, Novo Nordisk, Måløv, Denmark

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Jean-Christophe Jonas Université Catholique de Louvain, Institute of Experimental and Clinical Research, Pole of Endocrinology, Diabetes and Nutrition, Brussels, Belgium

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Michael B Wheeler Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Thomas Mandrup-Poulsen Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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generation of ROS from the mitochondria via the Fenton reaction ( Thomas et al . 2009 ) and in the cytosol via NAPDH oxidase activity ( Bedard & Krause 2007 ). Tissue iron overload confers risk for the development of diabetes ( Ellervik et al . 2001 , 2011

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0262
Volume/Issue:
Volume 61: Issue 2
Free access
Ermelindo C Leal Center for Neuroscience and Cell Biology, Center for Inovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal

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Tatiana Emanuelli Center for Neuroscience and Cell Biology, Center for Inovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal

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Diana Santos Center for Neuroscience and Cell Biology, Center for Inovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal

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João Moura Center for Neuroscience and Cell Biology, Center for Inovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal

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Ana Catarina RG Fonseca Center for Neuroscience and Cell Biology, Center for Inovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal

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Ana Burgeiro Center for Neuroscience and Cell Biology, Center for Inovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal

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Eugenia Carvalho Center for Neuroscience and Cell Biology, Center for Inovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal
Associação Protectora dos Diabéticos de Portugal (APDP), Lisbon, Portugal

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Introduction Diabetic foot ulcers (DFUs) are a major complication of diabetes, affecting 25% of patients with diabetes and preceding 84% of all lower extremity amputations ( Brem & Tomic-Canic 2007 ). Wound healing (WH) is a complex process

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-22-0122
Volume/Issue:
Volume 70: Issue 3
Restricted access