Search Results

You are looking at 1 - 10 of 246 items for :

  • chemical disruptors x
Clear All
Free access

Karen Jesus Oliveira, Maria Isabel Chiamolera, Gisele Giannocco, Carmen Cabanelas Pazos-Moura and Tania Maria Ortiga-Carvalho

( Zoeller et al . 2012 , Schug et al . 2016 ) a statement of principles and used the following definition to describe endocrine-disrupting chemicals (EDCs): chemicals, or mixtures of chemicals, which interfere with any aspect of hormone action ( Patisaul

Free access

Elin Swedenborg, Joëlle Rüegg, Sari Mäkelä and Ingemar Pongratz

Introduction With industrialization, the production of chemicals and their introduction into the environment has increased massively. Some of these chemicals act as endocrine disruptors as they disturb endogenous hormone signaling pathways

Free access

H Inoshita, H Masuyama and Y Hiramatsu

An endocrine-disrupting chemical (EDC) can alter endocrine functions through a variety of mechanisms, including nuclear receptor-mediated changes in protein synthesis, interference with membrane receptor binding, steroidogenesis or synthesis of other hormones. Although major chemicals have been shown to disrupt estrogenic actions mainly through their binding to estrogen receptor (ER) or androgen receptor, it is not clear how EDCs affect endocrine functions in vivo. We present evidence that the EDCs bisphenol A and phthalate activate ER-mediated transcription through interaction with TRAP220. Moreover, bisphenol A had positive effects on the interaction between ER-beta and TRAP220 and on the expression of ER-beta and TRAP220 compared with phthalate and estradiol in uterine tIssue. These data suggested that some EDCs might alter endocrine function through the change of the receptor and coactivator levels in uterine tIssue and through the different effect on the interaction between ERs and coactivator TRAP220.

Free access

Abby F Fleisch, Robert O Wright and Andrea A Baccarelli

epigenetic programming, has increased dramatically. Exogenous compounds that alter ‘hormonal and homeostatic systems’ (i.e. endocrine endpoints) have been termed ‘endocrine disrupting chemicals’ and were officially recognized in an Endocrine Society statement

Free access

Michael E Baker and Gary Hardiman

, providing important benefits for modern industrial societies. However, some of these chemicals disrupt a variety of hormone-regulated physiological pathways, including reproductive responses mediated by the estrogen receptor (ER) and androgen receptor (AR

Free access

Ciro Menale, Maria Teresa Piccolo, Grazia Cirillo, Raffaele A Calogero, Alfonso Papparella, Luigi Mita, Emanuele Miraglia Del Giudice, Nadia Diano, Stefania Crispi and Damiano Gustavo Mita

:10.3390/ijerph10115737 ). Li Y Burns KA Arao Y Luh CJ Korach KS 2012 Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor α and β in vitro

Free access

Marcel J M Schaaf

zebrafish ER involves research on the role of this receptor as a mediator of the activity of endocrine-disrupting chemicals (EDCs). EDCs are natural or synthetic compounds that occur in the environment and disrupt the function, levels and distribution of

Free access

Mu-Hsin Chang, Wei-Wen Kuo, Ray-Jade Chen, Ming-Chin Lu, Fuu-Jen Tsai, Wu-Hsien Kuo, Ling-Yun Chen, Wen-Jun Wu, Chih-Yang Huang and Chun-Hsien Chu

transgenic mice, the lack of an IGF-II/M6P receptor was associated with over proliferation of myocardial cells in ventricular hyperplasia ( Lau et al . 1994 ). Furthermore, IGF2R protein ribozyme disruption protects cardiac myocytes against hypoxia- and TNF

Free access

Amy L Filby, Karen L Thorpe and Charles R Tyler

Introduction It is now firmly established that a wide range of natural and anthropogenic chemicals present in the aquatic environment have the capacity to disrupt the endocrine system and, in turn, alter physiological function

Free access

Jason F Ohlstein, Amy L Strong, John A McLachlan, Jeffrey M Gimble, Matthew E Burow and Bruce A Bunnell

Lochard M Magnier AM Ibanez G 2013 Impact of endocrine disrupting chemicals on birth outcomes . Gynécologie, Obstétrique & Fertilité 41 601 – 610 . ( doi:10.1016/j.gyobfe.2013.08.012 ). Couture JP Blouin R 2011 The DLK gene is a