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Wenhui Su and Xinchun Liu

Introduction In mammals, the blood–testis barrier (BTB) that divides the seminiferous epithelium into the basal and the adluminal (apical) compartment provides an independent environment for the development of meiosis I/II and postmeiotic spermatid

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Wing-Yee Lui and Will M Lee

, neighboring Sertoli cells closely associate with each other to form the blood–testis barrier (BTB) that is constituted by inter-Sertoli tight junctions (TJ) and basal ectoplasmic specializations (ES, an atypical adherens junction (AJ) type). The BTB is

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Ariane Zamoner, Kátia Padilha Barreto, Danilo Wilhelm Filho, Fabíola Sell, Viviane Mara Woehl, Fátima Costa Rodrigues Guma, Regina Pessoa-Pureur and Fátima Regina Mena Barreto Silva

pivotal role in the regulation and maintenance of spermatogenesis and are the site of action of all hormonal influences modulating testis development. They also provide physical support to germ cells, form the blood–testis barrier, and secrete protein

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Wendy M van der Deure, Robin P Peeters and Theo J Visser

, Roberts et al . 2008 ). The importance of MCT8 in the blood–brain barrier and in the blood–cerebral spinal fluid (CSF) barrier is strongly suggested by the almost complete block in brain T 3 uptake in MCT8 knockout mice ( Trajkovic et al . 2007 ). The

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H Santti, L Mikkonen, A Anand, S Hirvonen-Santti, J Toppari, M Panhuysen, F Vauti, M Perera, G Corte, W Wurst, O A Jänne and J J Palvimo

abnormalities in chromosome condensation and segregation ( Mohr & Boswell 1999 , Betz et al. 2001 , Hari et al. 2001 ). PIASx is highly expressed in testis, and the protein can be detected in spermatogonia and pachytene spermatocytes up to stage

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Marcel E Dinger, Timothy R Mercer and John S Mattick

, Rassoulzadegan et al . 2006 , Chandler 2007 ). This process can be directed by miRNAs as well as other small RNAs and appears to require the action of the RNA methyltransferase Dnmt2 ( Cuzin 2007 ). Similar to the blood–brain barrier, the blood–testis barrier

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María Noel Galardo, María Fernanda Riera, Eliana Herminia Pellizzari, Selva Beatriz Cigorraga and Silvina Beatriz Meroni

cells are absolutely necessary in order to provide an adequate and protected environment within the seminiferous tubules. Germ cells situated beyond the blood testis barrier need to rely on Sertoli cell production of factors that fuel germ cell

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Elisabeth Sambroni, Antoine D Rolland, Jean-Jacques Lareyre and Florence Le Gac

in gonadal functions Taking into account that only Fsh is detected in the blood at the beginning of trout sexual maturation, one major objective of this study was to identify the transcripts that were regulated by Fsh in the testis during the pubertal

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Knut R Steffensen, Soek Ying Neo, Thomas M Stulnig, Vinsensius B Vega, Safia S Rahman, Gertrud U Schuster, Jan-Åke Gustafsson and Edison T Liu

anticipated previously. Only a few putative LXR target genes were found in brain and testis. Both tissues have a barrier against the circulating blood system providing protection from passive diffusion of compounds into these tissues, suggesting that

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N Hoggard, D V Rayner, S L Johnston and J R Speakman

MSH may therefore be the result of αMSH crossing the blood–brain barrier stimulating the sympathetic nervous system via MC3R and MC4R in the hypothalamus. However, a peripheral role for αMSH cannot be ruled out, and melanocortin receptors have been