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Karen Jesus Oliveira, Maria Isabel Chiamolera, Gisele Giannocco, Carmen Cabanelas Pazos-Moura and Tania Maria Ortiga-Carvalho

chemicals and bioactive compounds in food on the reproductive system. In addition to effects on the reproductive system, endocrine disruptors also affect different endocrine glands, including the thyroid, a fundamental gland for neural development. Thyroid

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Francisca Carvalhal, Marta Correia-da-Silva, Emília Sousa, Madalena Pinto and Anake Kijjoa

enormous resource of novel compounds for industrial development such as pharmaceuticals, food ingredients, cosmeceuticals, drug delivery systems and industrial enzymes ( Martins et al. 2014 ). In the past 50 years, progressive improvements have been

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Yanyan Cao, Yunsheng Li, Jaekyung Kim, Yulin Ren, Klaus Himmeldirk, Yi Liu, Yanrong Qian, Fengming Liu and Xiaozhuo Chen

aqueous compound solution. Healthy controls were gavaged with the same volume of ddH 2 O. Blood glucose, body weight, and food intake of the treated mice were measured once a week. Plasma samples of the treated mice were collected on selected weeks for the

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M Maggiolini, A G Recchia, D Bonofiglio, S Catalano, A Vivacqua, A Carpino, V Rago, R Rossi and S Andò

Introduction Piceatannol (PIC; 3,5,3′,4′-tetrahydroxy-trans-stilbene) and myricetin (MYR; 3,3′,4′,5,5′,7-hexahydroxyflavone) (Fig. 1 ) are phenolic compounds that occur naturally in grapes and red wine (MacDonald et al. 1998

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Sushi Jiang, Hening Zhai, Danjie Li, Jiana Huang, Heng Zhang, Ziru Li, Weizhen Zhang and Geyang Xu

are GLP1(7–37) and GLP1(7–36)NH2 ( Orskov et al . 1993 ). The half-life of bioactive GLP1 in the circulation is less than 2 min owing to rapid inactivation by the ubiquitous proteolytic enzyme dipeptidyl peptidase-4 (DPP4) ( Deacon et al . 1995

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Ulrich Schweizer and Clemens Steegborn

recently determined crystal structure of mouse Dio3 (mDio3; Schweizer et al . 2014 a ). We will shortly discuss modulatory compounds and emerging drug development opportunities. There are many ways to skin a cat: dehalogenating and deiodinating enzymes

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Eiji Munetsuna, Sachie Nakabayashi, Rie Kawanami, Kaori Yasuda, Miho Ohta, Midori A Arai, Atsushi Kittaka, Tai C Chen, Masaki Kamakura, Shinichi Ikushiro and Toshiyuki Sakaki

of 1α,25(OH) 2 D 3 , 19-nor-vitamin D compounds such as 1α,25-dihydroxy-19-nor-vitamin D 3 (1α,25(OH) 2 -19-nor-D 3 ) and 1α,25-dihydroxy-19-nor-vitamin D 2 (1α,25(OH) 2 -19-nor-D 2 ) have received most of the attention ( Sicinski et al . 2007

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Niamh X Cawley, Zhaojin Li and Y Peng Loh

-dependent sorting and recycling of lysosomal enzymes, sorting of POMC to the RSP was prevented in the presence of chloroquine ( Moore et al . 1983 a ), a compound that neutralizes acidic compartments. In the presence of chloroquine, reduced production of newly

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Ting-Ting Zhou, Fei Ma, Xiao-Fan Shi, Xin Xu, Te Du, Xiao-Dan Guo, Gai-Hong Wang, Liang Yu, Vatcharin Rukachaisirikul, Li-Hong Hu, Jing Chen and Xu Shen

as an anti-T2DM drug lead compound. The small molecule DMT was determined by cell-based screening against the lab in-house compound library partly purchased from SPECS commercial company. To date, there is no report on the bioactivity of DMT, although

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Zhengjie Yan, Youjin Dai, Heling Fu, Yuan Zheng, Dan Bao, Yuan Yin, Qin Chen, Xiaowei Nie, Qingting Hao, Daorong Hou and Yugui Cui

University, Nanjing, China and housed under a 12-h darkness/light cycle in an animal facility with a controlled temperature (20–25°C) and humidity (40%–70%). Food and water were provided ad libitum throughout the study. The mice were allowed to acclimatize