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Fabien Duval, Esther Dos Santos, Hadia Moindjie, Valérie Serazin, Nelly Swierkowski-Blanchard, François Vialard, and Marie-Noëlle Dieudonné

trophoblasts and ESCs. Adiponectin is a 30 kDa cytokine, predominantly produced by adipose tissue ( Kern et al. 2003 ). Adiponectin exerts its action via two specific receptors (ADIPOR1 and ADIPOR2) containing seven transmembrane domains but which are

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Fabien Duval, Esther Dos Santos, Benoît Maury, Valérie Serazin, Khadija Fathallah, François Vialard, and Marie-Noëlle Dieudonné

process is called glycophagy ( Kaur & Debnath 2015 ). It can be hypothesized that endometrial glycogen follows this pathway and thus provides placental cells and/or the fetus with glucose. Adiponectin is a 30 kDa protein that is described as an insulin

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Naoki Hattori, Ayato Yamada, Shunya Nakatsuji, Takeshi Matsuda, Norito Nishiyama, and Akira Shimatsu

Introduction Adipocytes produce several types of cytokines, termed ‘adipocytokines’, which include adiponectin and leptin ( Tilg & Moschen 2006 ). Adiponectin suppresses hepatic gluconeogenesis by inhibiting the related gene expression

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Hui Wang, Wenjing Wu, Jun Duan, Ming Ma, Wei Kong, Yuannan Ke, Gang Li, and Jingang Zheng

a potential benefit for the development of pharmacological therapies for heart injuries induced by acute MI. Adiponectin (APN) is an adipocyte-derived cytokine normally present in human plasma at concentrations of 0.5–30 µg/mL, comprising about 0

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Toshihiro Kobayashi, Hitomi Imachi, Kensaku Fukunaga, Jingya Lyu, Seisuke Sato, Takanobu Saheki, Tomohiro Ibata, Mari Matsumoto, Salimah B Japar, and Koji Murao

that contribute to the regulation of energy metabolism in the body. Adiponectin (APN), an adipokine, is an adipocyte-derived vasoactive peptide with anti-inflammatory and insulin-sensitizing peptides. A number of clinical trials have shown that subjects

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Vivian Vu, Phuong Bui, Megumi Eguchi, Aimin Xu, and Gary Sweeney

Introduction The beneficial effects of adiponectin on peripheral metabolism are now well characterized ( Yamauchi & Kadowaki 2008 , Matsuzawa 2010 , Dadson et al . 2011 ). Adiponectin targets multiple metabolic tissues including skeletal muscle

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Zhi Zhang, Fang Wang, Bing-jian Wang, Guang Chu, Qunan Cao, Bao-Gui Sun, and Qiu-Yan Dai

artery endothelial cells and smooth muscle cells ( Kang et al . 2000 , Knudson et al . 2005 ). However, the role of leptin in vascular ECM remodelling remains unclear. Unlike leptin, which has profibrogenic effects, adiponectin, a 30-kDa adipokine, is

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Penny Ahlstrom, Esther Rai, Suharto Chakma, Hee Ho Cho, Palanivel Rengasamy, and Gary Sweeney

adiponectin with diabetes and skeletal muscle insulin resistance exists in humans and animal models ( Stern et al. 2016 ). Adiponectin is now established as an anti-diabetic hormone ( Cheng et al. 2014 ). Muscle is one important target tissue of

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Gabriela Capllonch-Amer, Isabel Lladó, Ana M Proenza, Francisco J García-Palmer, and Magdalena Gianotti

tissue (WAT) is more than a simple fat deposit, as it is an endocrine organ that contributes to energy homeostasis mechanisms by releasing proteins that are commonly referred to as adipokines ( Harwood 2012 , Henry et al . 2012 ). Adiponectin is an

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Philip W Peake, Jaquelyne T Hughes, Yvonne Shen, and John A Charlesworth

Introduction Adiponectin is an adipocyte-specific protein related in structure to the complement component Clq. As with C1q, it self-associates into trimers, as well as higher molecular weight isoforms. Depending upon the assay