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Caroline M Gorvin

et al . 2016 , 2017 a , Piret et al . 2016 ). FHH type-3 (FHH3) is due to mutations in the sigma subunit of the adaptor protein-2 (AP2σ), which plays a fundamental role in clathrin-mediated endocytosis of transmembrane proteins, such as GPCRs

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Fadil M Hannan, Valerie N Babinsky and Rajesh V Thakker

that comprises the calcium-sensing receptor (CaSR), G-protein α-11 (Gα 11 ) subunit and adaptor-related protein complex 2 sigma (AP2σ) subunit ( Pollak et al . 1993 , Nesbit et al . 2013 a , b ). This article will provide an overview of the role of

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Lorella Bonaccorsi, Daniele Nosi, Monica Muratori, Lucia Formigli, Gianni Forti and Elisabetta Baldi

results indicate that reduced internalization in PC3-AR cells is associated with lack of autotransphosphorylation in several tyrosine residues. Recruitment of adaptor proteins Grb2 and c-Cbl and ubiquitination of EGFR are altered

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Arnaud Droit, Guy G Poirier and Joanna M Hunter

in proteomics today are two-dimensional sodium dodecylsulfate polyacrylamide gel electrophoresis (2D SDS-PAGE) for protein separation, mass spectrometry (MS) and protein identification through manual interpretation or database correlation of mass

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Eirini Meimaridou, Sakina B Gooljar and J Paul Chapple

clathrin adapter proteins and the binding of clathrin to the PM and trans -golgi network. Interestingly, in GAK conditional knockout mouse embryonic fibroblasts, adaptor proteins including AP2, epsin, Eps15 and EPs15R have been reported to be mislocalized

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Dan Hanson, Adam Stevens, Philip G Murray, Graeme C M Black and Peter E Clayton

family (TCP1, CCT2, CCT3 and CCT6A) were present in the 3-M interactome and predict they may act as adaptor proteins within the CUL7 SCF complex. IP experiments from lysates of HEK293 cells overexpressing CUL7, V5-OBSL1 and CCDC8 confirmed the interaction

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Qi Zhang and Wen Xuan Wu

progesterone. Using SSH, we identified a marked increase in annexin 2 mRNA associated with progesterone treatment. Annexins are a family of cytosolic Ca 2+ -dependent phospholipid-binding proteins that form an evolutionarily conserved multigene family

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Michael Welsh, Maria Jamalpour, Guangxiang Zang and Björn Åkerblom

Rynditch A 2013 The LMP2A protein of Epstein–Barr virus regulates phosphorylation of ITSN1 and Shb adaptors by tyrosine kinases . Cellular Signalling 25 33 – 40 . ( doi:10.1016/j.cellsig.2012.09.011 ). Dixelius J Larsson H Sasaki T

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Seán P Barry, Kevin M Lawrence, James McCormick, Surinder M Soond, Mike Hubank, Simon Eaton, Ahila Sivarajah, Tiziano M Scarabelli, Richard A Knight, Christoph Thiemermann, David S Latchman, Paul A Townsend and Anastasis Stephanou

Transmembrane 9 superfamily member 1 3.1 0.02 1368867_at Eif2c2 Eukaryotic translation initiation factor 2C, 2 3.0 0.05 1386877_at Ap2s1 Adaptor-related protein complex 2, sigma 1 subunit 3.0 0.03 1367562_at Sparc Secreted acidic cysteine-rich glycoprotein −2

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Guillaume Pidoux and Kjetil Taskén

. cAMP (red filled circles) has effects on a range of effector molecules encompassing 1) PKA, 2) PDEs, 3) guanine nucleotide exchange factors (GEFs) known as exchange proteins activated by cAMP (Epacs), and 4) cyclic nucleotide-gated ion channels