fraction of APN ( Kangas-Kontio et al. 2010 ). HMW APN has a high correlation coefficient, independent of various factors of adiposity and insulin sensitivity ( Im et al. 2006 ). The mouse scavenger receptor class B type I (SR-BI) mediates the
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Toshihiro Kobayashi, Hitomi Imachi, Kensaku Fukunaga, Jingya Lyu, Seisuke Sato, Takanobu Saheki, Tomohiro Ibata, Mari Matsumoto, Salimah B Japar, and Koji Murao
P Perez-Martinez, J Lopez-Miranda, JM Ordovas, C Bellido, C Marin, P Gomez, JA Paniagua, JA Moreno, F Fuentes, and F Perez-Jimenez
It has recently been reported that carriers of the less common allele at the scavenger receptor class B type I (SR-BI) exon 1 polymorphism are more susceptible to the presence of saturated fatty acid in the diet because of a greater increase in LDL cholesterol. Our aim was to determine if this polymorphism could also influence postprandial lipoprotein metabolism, because the SR-BI has been described as a possible mediator in the intestinal absorption of triacylglycerols. Forty-seven normolipidemic volunteers who were homozygous for the E3 allele at the APOE gene were selected [37 homozygous for the common genotype (1/1) at the SR-BI exon 1 polymorphism and 10 heterozygous (1/2)]. They were given a fat-rich meal containing 1 g fat and 7 mg cholesterol per kg body weight and vitamin A 60,000 IU/m2 body surface. Fat accounted for 60% of calories, and protein and carbohydrates accounted for 15% and 25% of energy respectively. Blood samples were taken at time 0, every 1 h until 6 h, and every 2.5 h until 11 h. Total cholesterol and triacylglycerols in plasma, and cholesterol, triacylglycerols and retinyl palmitate in triacylglycerol-rich lipoproteins (large and small triacylglycerol-rich lipoproteins) were determined. Postprandial responses for triacylglycerols and retinyl palmitate in small triacylglycerol-rich lipoproteins were higher in 1/1 individuals than in 1/2 individuals. No other significant differences were noted. Our data show that the presence of the genotype 1/2 is associated with a lower postprandial lipemic response.
Hiromi Nagata, Jingya Lyu, Hitomi Imachi, Kensaku Fukunaga, Seisuke Sato, Toshihiro Kobayashi, Takanobu Saheki, Kayoko Seo, Japar B Salimah, Hisakazu Iwama, Ryuichi Sakamoto, Yoshihiro Ogawa, and Koji Murao
metabolism and excretion ( Tall 1990 ). Mouse scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesterol ester in transfected Chinese hamster ovary (CHO) cells. This finding provides an important link between a specific cell
Michael P Corcoran, Alice H Lichtenstein, Mohsen Meydani, Alice Dillard, Ernst J Schaefer, and Stefania Lamon-Fava
Rader DJ 2007 Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo . Journal of Clinical Investigation 117 2216 – 2224 . doi:10.1172/JCI32057 . Weidtmann A Scheithe R Hrboticky N Pietsch
Pulak R Manna, Syam P Chandrala, Youngah Jo, and Douglas M Stocco
following primer pairs: StAR sense, 5′-GACCTT-GAAAGGCTCAGGAAGAAC-3′, and, StAR antisense, 5′-TAGCTGAAGATGGACAGACTTGC-3′ and SR-BI sense, 5′-CTCATCCAAGCAGCAGGTGCTCAAGAA-3′ and, SR-BI antisense, 5′-TGTTTGCCAACGGGTCCGTC-TACCCACC-3′ respectively. The L19
Shulin Zhang, Melinda Chan, and Jane E Aubin
2001 ), but the frequency of various monopotential versus bi- or multipotential cells in RC populations remains unknown. The steroid hormone 1,25-dihydroxyvitamin D3 (1,25(OH) 2 D 3 ) has diverse effects on many cell lineages, including
Carolin L Piechowski, Anne Rediger, Christina Lagemann, Jessica Mühlhaus, Anne Müller, Juliane Pratzka, Patrick Tarnow, Annette Grüters, Heiko Krude, Gunnar Kleinau, and Heike Biebermann
Deutsche Forschungsgemeinschaft (BI 893/2-1, BI893/5-1, BI893/6-2) and graduate school 1208: Hormonal Regulation of Energy Metabolism, Body Weight and Growth, TP1. Author contribution statement C L P, H B, G K, and A R were involved in conception and design
Junye Chen, Yi Lu, Mengyuan Tian, and Qiren Huang
Karki S Qiang L Tao R Kim J Luo Z Farmer SR Kandror KV 2011 SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL . Journal of Lipid Research 52 1693 – 1701 . ( https://doi.org/10.1194/jlr.M014647 ) 10.1194/jlr.M014647
Hui Huang and Ya-Xiong Tao
GM Ghatei MA Smith DM Bloom SR 2000 Investigation of the melanocyte stimulating hormones on food intake. Lack of evidence to support a role for the melanocortin-3-receptor . Brain Research 869 203 – 210 . ( doi:10.1016/S0006
Raquel Tobar-Rubin, Dahlia Sultan, Daniela Janevska, Kyle Turcic, Julie Carroll, Laura Ooms, and Robin Pals-Rylaarsdam
+ : a crystallographic titration experiment . Biochemistry 37 14376 – 14385 . ( doi:10.1021/bi9810306 ). Coleman DE Berghuis AM Lee E Linder ME Gilman AG Sprang SR 1994 Structures of active conformations of Giα1 and the mechanism of
