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Chunheng Mo Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, People’s Republic of China

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Long Huang Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, People’s Republic of China

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Lin Cui Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, People’s Republic of China

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Can Lv Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, People’s Republic of China

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Dongliang Lin Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, People’s Republic of China

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Liang Song Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, People’s Republic of China

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Guoqiang Zhu Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, People’s Republic of China

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Juan Li Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, People’s Republic of China

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Yajun Wang Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, People’s Republic of China

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tract smooth muscle ( Erspamer et al . 1972 ). Subsequently, two structurally and functionally related bombesin-like peptides encoded by separate genes, gastrin-releasing peptide (GRP) and neuromedin B (NMB), have also been identified in mammals

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Zhiyu Ma College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China
College of Veterinary Medicine, Yangzhou University, Yangzhou, People’s Republic of China

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Ying Zhang College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Juan Su College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Sheng Yang College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Wenna Qiao College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Xiang Li College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Zhihai Lei College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Ling Cheng College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Na An College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Wenshao Wang College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Yanyan Feng College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Jinlong Zhang College of Veterinary Medicine, Yangzhou University, Yangzhou, People’s Republic of China

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Introduction Neuromedin B (NMB), a mammalian bombesin-related peptide, was originally identified in porcine spinal cord ( Minamino et al . 1983 ) and has been found to be present mainly in the central nervous system as well as several

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N Hoggard Rowett Research Institute, Aberdeen Centre for Energy Regulation and Obesity (ACERO), Bucksburn, Aberdeen AB21 9SB, UK
ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen, UK
Department of Surgery, Dr Gray’s Hospital, Elgin, UK

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S Bashir Rowett Research Institute, Aberdeen Centre for Energy Regulation and Obesity (ACERO), Bucksburn, Aberdeen AB21 9SB, UK
ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen, UK
Department of Surgery, Dr Gray’s Hospital, Elgin, UK

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M Cruickshank Rowett Research Institute, Aberdeen Centre for Energy Regulation and Obesity (ACERO), Bucksburn, Aberdeen AB21 9SB, UK
ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen, UK
Department of Surgery, Dr Gray’s Hospital, Elgin, UK

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J D B Miller Rowett Research Institute, Aberdeen Centre for Energy Regulation and Obesity (ACERO), Bucksburn, Aberdeen AB21 9SB, UK
ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen, UK
Department of Surgery, Dr Gray’s Hospital, Elgin, UK

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J R Speakman Rowett Research Institute, Aberdeen Centre for Energy Regulation and Obesity (ACERO), Bucksburn, Aberdeen AB21 9SB, UK
ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen, UK
Department of Surgery, Dr Gray’s Hospital, Elgin, UK

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contractive effects on the colon or ileum ( Erspamer et al. 1970 ). Neuromedin B (NMB) is a member of a family of BN-like peptides, which in mammals also include gastrin-releasing peptide (GRP) and neuromedin ( McDonald et al. 1979 , Minamino et al

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Gabriela Silva Monteiro de Paula Molecular Endocrinology Laboratory, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

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Marianna Wilieman Molecular Endocrinology Laboratory, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

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Karina Ribeiro Silva Molecular Endocrinology Laboratory, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Post-Graduation Program of Biotechnology, National Institute of Metrology, Quality and Technology – INMETRO, Rio de Janeiro, Brazil
Multidisciplinary Center for Biological Research (Numpex-Bio), Federal University of Rio de Janeiro – Campus of Duque de Caxias, Rio de Janeiro, Brazil

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Leandra Santos Baptista Post-Graduation Program of Biotechnology, National Institute of Metrology, Quality and Technology – INMETRO, Rio de Janeiro, Brazil
Multidisciplinary Center for Biological Research (Numpex-Bio), Federal University of Rio de Janeiro – Campus of Duque de Caxias, Rio de Janeiro, Brazil

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Sihem Boudina Department of Nutrition and Integrative Physiology, University of Utah School of Medicine, Salt Lake City, Utah, USA

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Luana Lopes de Souza Molecular Endocrinology Laboratory, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

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Thais Bento-Bernardes Molecular Endocrinology Laboratory, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

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Karina Dutra Asensi Cellular and Molecular Cardiology Laboratory, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
National Center of Structural Biology and Bioimage – CENABIO, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

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Regina Coeli dos Santos Goldenberg Cellular and Molecular Cardiology Laboratory, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

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Carmen Cabanelas Pazos-Moura Molecular Endocrinology Laboratory, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

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GGCTGACAGGTGGCTATTT GGCACAACTAATGAAGGTTTGG Hprt GCAGTACAGCCCCAAAATGG AACAAAGTCTGGCCTGTATCCAA Lep GGCTTTGGTCCTATCTGTCTTAT ATTCTCCAGGTCATTGGCTATC Nmb GCAGATCATGACTCAGCTGTAG CAAGATTCGAGTGCACCCT Nmbr CCCTACCCACAAACAGATGAG

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K J Oliveira Laboratório de Endocrinologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21949-900, Brazil
Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

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T M Ortiga-Carvalho Laboratório de Endocrinologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21949-900, Brazil
Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

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A Cabanelas Laboratório de Endocrinologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21949-900, Brazil
Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

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M A L C Veiga Laboratório de Endocrinologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21949-900, Brazil
Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

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K Aoki Laboratório de Endocrinologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21949-900, Brazil
Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

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H Ohki-Hamazaki Laboratório de Endocrinologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21949-900, Brazil
Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

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K Wada Laboratório de Endocrinologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21949-900, Brazil
Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

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E Wada Laboratório de Endocrinologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21949-900, Brazil
Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

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C C Pazos-Moura Laboratório de Endocrinologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21949-900, Brazil
Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

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receptor (NMB-R) implies the involvement of NMB/NMB-R in 5-HT neuron function. Brain Research 942 71 –78. Yamada K , Santo-Yamada Y & Wada K 2002b Restraint stress impaired maternal behavior in female mice lacking the

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Hamedeh Ghanaat-Pour Department of Internal Medicine, Karolinska Institute, Stockholm South Hospital, SE-118 83 Stockholm, Sweden

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Zhen Huang Department of Internal Medicine, Karolinska Institute, Stockholm South Hospital, SE-118 83 Stockholm, Sweden

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Mikael Lehtihet Department of Internal Medicine, Karolinska Institute, Stockholm South Hospital, SE-118 83 Stockholm, Sweden

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Åke Sjöholm Department of Internal Medicine, Karolinska Institute, Stockholm South Hospital, SE-118 83 Stockholm, Sweden

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/phosphodiesterase 3 (Enpp3) 1.6 NM_133298 Glycoprotein (transmembrane) nmb (Gpnmb) 1.6 NM_012907 Apolipoprotein B editing complex 1 (Apobec1) 2.5 NM_053963 Matrix metallopeptidase 12 (Mmp12) 2.5 AA849399 Cathepsin Z (Ctsz) 2 NM_017320 Cathepsin S (cathepsin S) 2.5 L

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Ke-Hung Tsui Department of Urology, Bioinformation Center, School of Traditional Chinese Medicine, School of Nursing, Department of Anatomy, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan
Department of Urology, Bioinformation Center, School of Traditional Chinese Medicine, School of Nursing, Department of Anatomy, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan

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Ying-Ling Chang Department of Urology, Bioinformation Center, School of Traditional Chinese Medicine, School of Nursing, Department of Anatomy, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan

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Tsui-Hsia Feng Department of Urology, Bioinformation Center, School of Traditional Chinese Medicine, School of Nursing, Department of Anatomy, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan

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Li-Chuan Chung Department of Urology, Bioinformation Center, School of Traditional Chinese Medicine, School of Nursing, Department of Anatomy, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan

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Tzu-Yi Lee Department of Urology, Bioinformation Center, School of Traditional Chinese Medicine, School of Nursing, Department of Anatomy, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan

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Phei-Lang Chang Department of Urology, Bioinformation Center, School of Traditional Chinese Medicine, School of Nursing, Department of Anatomy, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan
Department of Urology, Bioinformation Center, School of Traditional Chinese Medicine, School of Nursing, Department of Anatomy, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan

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Horng-Heng Juang Department of Urology, Bioinformation Center, School of Traditional Chinese Medicine, School of Nursing, Department of Anatomy, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan
Department of Urology, Bioinformation Center, School of Traditional Chinese Medicine, School of Nursing, Department of Anatomy, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan

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proliferation and cell invasion in prostate carcinoma cells . International Journal of Cancer 130 2812 – 2823 . doi:10.1002/ijc.26284 . Tsui KH Chung LC Feng TH Chang PL Juang HH 2012b Glycoprotein transmembrane nmb: an androgen

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