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Gabriela Capllonch-Amer Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5, E-07122 Palma de Mallorca, Illes Balears, Spain

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Isabel Lladó Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5, E-07122 Palma de Mallorca, Illes Balears, Spain
Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5, E-07122 Palma de Mallorca, Illes Balears, Spain

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Ana M Proenza Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5, E-07122 Palma de Mallorca, Illes Balears, Spain
Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5, E-07122 Palma de Mallorca, Illes Balears, Spain

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Francisco J García-Palmer Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5, E-07122 Palma de Mallorca, Illes Balears, Spain
Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5, E-07122 Palma de Mallorca, Illes Balears, Spain

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Magdalena Gianotti Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5, E-07122 Palma de Mallorca, Illes Balears, Spain
Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5, E-07122 Palma de Mallorca, Illes Balears, Spain

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 h to a final concentration of 10 nM E 2 , 1 μM progesterone (Pg), and testosterone. When corresponded, 10 μM FLT, an androgen receptor (AR) blocker ( Labrie 1993 ), was added to the plate 1 h before Pg or testosterone. In sex hormone

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-13-0201
Volume/Issue:
Volume 52: Issue 2
Free access
Dominique H Eghlidi Department of Neurology and Division of Sleep Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

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Vasilios T Garyfallou Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon, USA

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Steven G Kohama Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon, USA

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Henryk F Urbanski Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon, USA
Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon, USA
Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA
Department of Physiology & Pharmacology, Oregon Health & Science University, Portland, Oregon, USA

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). Experimental design The male monkeys were assigned to one of the following three groups: Young ( n  = 6), Old ( n  = 7) and Old HS ( n  = 6); in the latter group, the animals were given daily oral hormonal supplements (HS), comprising testosterone (T) and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0094
Volume/Issue:
Volume 59: Issue 2
Free access
Nathan Appanna Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, Oxfordshire, UK

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Hylton Gibson Department of Biochemistry, Stellenbosch University, Stellenbosch, Western Cape, South Africa

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Elena Gangitano Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, Oxfordshire, UK
Department of Experimental Medicine, Sapienza University of Rome, Rome, Lazio, Italy

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Niall J Dempster Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, Oxfordshire, UK

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Karen Morris Biochemistry Department, Manchester University NHS Trust, Manchester Academic Health Science Centre, Manchester, Greater Manchester, UK

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Sherly George Biochemistry Department, Manchester University NHS Trust, Manchester Academic Health Science Centre, Manchester, Greater Manchester, UK

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Anastasia Arvaniti Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, Oxfordshire, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, Oxfordshire, UK

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Laura L Gathercole Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, Oxfordshire, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, Oxfordshire, UK

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Brian Keevil Biochemistry Department, Manchester University NHS Trust, Manchester Academic Health Science Centre, Manchester, Greater Manchester, UK

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Trevor M Penning Center of Excellence in Environmental Toxicology and Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

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Karl-Heinz Storbeck Department of Biochemistry, Stellenbosch University, Stellenbosch, Western Cape, South Africa

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Jeremy W Tomlinson Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, Oxfordshire, UK

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Nikolaos Nikolaou Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, Oxfordshire, UK

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/L glucose, and supplemented with 10% foetal bovine serum, 1% penicillin/streptomycin and 1% non-essential amino acids (Thermo Fisher Scientific). Cells were grown at 37°C in a 5% CO 2 setting. Dexamethasone, cortisol, prednisolone, testosterone

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-20-0160
Volume/Issue:
Volume 66: Issue 3
Open access
Silvia Giatti Department of Pharmacological and Biomolecular Sciences, Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano, Milan, Italy

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Roberto Cosimo Melcangi Department of Pharmacological and Biomolecular Sciences, Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano, Milan, Italy

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Marzia Pesaresi Department of Pharmacological and Biomolecular Sciences, Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano, Milan, Italy

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testosterone or PROG. Progestins structurally related to testosterone Progestins structurally related to testosterone are subdivided into those containing an ethinyl group at carbon 17 and those nonethinylated ( Fig. 2 ). The substitution of a hydrogen on

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-16-0061
Volume/Issue:
Volume 57: Issue 2
Free access
Matias Knuuttila Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, and Turku Center for Disease Modeling, University of Turku, Turku, Finland

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Esa Hämäläinen Department of Clinical Chemistry and HUSLAB, Helsinki University and Helsinki University Hospital, HUSLAB, Helsinki, Finland

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Matti Poutanen Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, and Turku Center for Disease Modeling, University of Turku, Turku, Finland
Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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immunoassays may be adequate for the screening of serum testosterone (T) concentrations in the normal physiological range of men ( Taylor et al . 2015 ), problems with sensitivity, specificity and reproducibility of the direct immunoassays emerge for most

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JME-18-0150
Volume/Issue:
Volume 62: Issue 4
Free access
Ye Zhou Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Road, Beckman 2310, Duarte, California 91010, USA

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Maya Otto-Duessel Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Road, Beckman 2310, Duarte, California 91010, USA

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Miaoling He Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Road, Beckman 2310, Duarte, California 91010, USA

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Susan Markel Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Road, Beckman 2310, Duarte, California 91010, USA

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Tim Synold Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Road, Beckman 2310, Duarte, California 91010, USA

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Jeremy O Jones Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Road, Beckman 2310, Duarte, California 91010, USA

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). However, several cross-sectional studies have found that a low testosterone level at the time of PC diagnosis is correlated with a more aggressive disease ( Schatzl et al . 2001 ). Additionally, in one of the largest and most thorough analyses to date

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-13-0060
Volume/Issue:
Volume 51: Issue 1
Free access
Xueting Wang Institute of Nautical Medicine, Nantong University, Nantong, Jiangsu, China
Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China

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Zhiran Zou Institute of Nautical Medicine, Nantong University, Nantong, Jiangsu, China
Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China

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Zhihui Yang Institute of Nautical Medicine, Nantong University, Nantong, Jiangsu, China
Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China

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Shan Jiang Institute of Nautical Medicine, Nantong University, Nantong, Jiangsu, China
Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China

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Yapeng Lu Institute of Nautical Medicine, Nantong University, Nantong, Jiangsu, China
Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China

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Dan Wang Institute of Nautical Medicine, Nantong University, Nantong, Jiangsu, China
Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China

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Zhangji Dong Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Nantong, Jiangsu, China

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Sha Xu Medical College of Soochow University, Suzhou, Jiangsu, China

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Li Zhu Institute of Nautical Medicine, Nantong University, Nantong, Jiangsu, China
Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China

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). However, the mechanism of HIF1 affecting/regulating Leydig cell functions is not clearly elucidated. The main function of Leydig cells is synthesizing and secreting testosterone, producing 95% of the total amount in males ( Svechnikov et al . 2010

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-18-0148
Volume/Issue:
Volume 62: Issue 1
Free access
Denis Delić Division of Molecular Parasitology, Bayer Healthcare AG, Zoology Department, Department of Biology and Centre for Biological and Medical Research, Heinrich-Heine-University Duesseldorf, Universitaetstrasse 1, 40225 Duesseldorf, Germany

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Nicole Gailus Division of Molecular Parasitology, Bayer Healthcare AG, Zoology Department, Department of Biology and Centre for Biological and Medical Research, Heinrich-Heine-University Duesseldorf, Universitaetstrasse 1, 40225 Duesseldorf, Germany

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Hans-Werner Vohr Division of Molecular Parasitology, Bayer Healthcare AG, Zoology Department, Department of Biology and Centre for Biological and Medical Research, Heinrich-Heine-University Duesseldorf, Universitaetstrasse 1, 40225 Duesseldorf, Germany

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Mohamed Dkhil Division of Molecular Parasitology, Bayer Healthcare AG, Zoology Department, Department of Biology and Centre for Biological and Medical Research, Heinrich-Heine-University Duesseldorf, Universitaetstrasse 1, 40225 Duesseldorf, Germany

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Saleh Al-Quraishy Division of Molecular Parasitology, Bayer Healthcare AG, Zoology Department, Department of Biology and Centre for Biological and Medical Research, Heinrich-Heine-University Duesseldorf, Universitaetstrasse 1, 40225 Duesseldorf, Germany

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Frank Wunderlich Division of Molecular Parasitology, Bayer Healthcare AG, Zoology Department, Department of Biology and Centre for Biological and Medical Research, Heinrich-Heine-University Duesseldorf, Universitaetstrasse 1, 40225 Duesseldorf, Germany
Division of Molecular Parasitology, Bayer Healthcare AG, Zoology Department, Department of Biology and Centre for Biological and Medical Research, Heinrich-Heine-University Duesseldorf, Universitaetstrasse 1, 40225 Duesseldorf, Germany

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Introduction Testosterone is known to increase susceptibility to a wide variety of infectious diseases ( Müller 1992 , Klein 2000 , Roberts et al . 2001 , Marriott & Huet-Hudson 2006 ), which also concerns human malaria ( Müller 1992 , Kurtis

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-10-0026
Volume/Issue:
Volume 45: Issue 6
Free access
Juan Carlos Arapa-Diaz Department of Physiological Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, Brazil

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Wender do Nascimento Rouver Department of Physiological Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, Brazil

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Jéssyca Aparecida Soares Giesen Department of Physiological Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, Brazil

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Marcela Daruge Grando Department of Physics and Chemistry, Faculty of Pharmaceutical Sciences from Ribeirão Preto, University of São Paulo, São Paulo, Brazil

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Lusiane Maria Bendhack Department of Physics and Chemistry, Faculty of Pharmaceutical Sciences from Ribeirão Preto, University of São Paulo, São Paulo, Brazil

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Roger Lyrio dos Santos Department of Physiological Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, Brazil

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postmenopausal women compared to premenopausal women points to the female sex hormone estrogen having a protective vascular effect ( Farhat et al. 1996 , Benjamin et al. 2018 ), whereas testosterone appears to exacerbate the development of CVDs ( Adams et

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-20-0153
Volume/Issue:
Volume 65: Issue 4
Restricted access
M Vigier UMR INSERM 418/INRA 1245/Université Claude-Bernard Lyon 1, Hôpital Debrousse, 29 Rue Soeur Bouvier, 69322 Lyon Cedex 05, France

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M Weiss UMR INSERM 418/INRA 1245/Université Claude-Bernard Lyon 1, Hôpital Debrousse, 29 Rue Soeur Bouvier, 69322 Lyon Cedex 05, France

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M H Perrard UMR INSERM 418/INRA 1245/Université Claude-Bernard Lyon 1, Hôpital Debrousse, 29 Rue Soeur Bouvier, 69322 Lyon Cedex 05, France

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M Godet UMR INSERM 418/INRA 1245/Université Claude-Bernard Lyon 1, Hôpital Debrousse, 29 Rue Soeur Bouvier, 69322 Lyon Cedex 05, France

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P Durand UMR INSERM 418/INRA 1245/Université Claude-Bernard Lyon 1, Hôpital Debrousse, 29 Rue Soeur Bouvier, 69322 Lyon Cedex 05, France

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Introduction The role of follicle-stimulating hormone (FSH) and testosterone in spermatogenesis has been the subject of numerous studies and controversies for several decades ( Sharpe 1994 , McLachlan et al. 2002 ). Indeed, what

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01493
Volume/Issue:
Volume 33: Issue 3
Free access