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Yuiko Matsumoto Section of Integrative Biology, University of Texas at Austin, Austin, Texas 78712, USA

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Ryohei Yatsu Section of Integrative Biology, University of Texas at Austin, Austin, Texas 78712, USA

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Caitlin Taylor Section of Integrative Biology, University of Texas at Austin, Austin, Texas 78712, USA

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David Crews Section of Integrative Biology, University of Texas at Austin, Austin, Texas 78712, USA

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incubated at 31 °C become females (female-producing temperature or FPT). The effect of the incubation temperature is only observed midway through development, also known as the temperature-sensitive period (TSP). Exogenous ligands (steroid hormones and

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Syed Kashif Zaidi Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA
Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

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Wen-Jun Shen Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA
Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

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Stefanie Bittner Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

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Alex Bittner Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

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Mark P McLean Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

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Jiahuai Han Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

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Roger J Davis Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

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Fredric B Kraemer Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA
Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

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Salman Azhar Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA
Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA

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Introduction Extensive experimental evidence now indicates that aging in humans and animal models is associated with a general decline in steroid hormone production ( Zaidi et al . 2012 ). Similarly, a number of in vitro studies have clearly

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Li Li Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina 27695-7566, USA
The Hamner Institutes for Health Sciences, CIIT Centers for Health Research, Division of Computational Biology, 6 Davis Drive, PO Box 12137, Research Triangle Park, North Carolina 27709-2137, USA

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Melvin E Andersen Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina 27695-7566, USA
The Hamner Institutes for Health Sciences, CIIT Centers for Health Research, Division of Computational Biology, 6 Davis Drive, PO Box 12137, Research Triangle Park, North Carolina 27709-2137, USA

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Steffen Heber Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina 27695-7566, USA
The Hamner Institutes for Health Sciences, CIIT Centers for Health Research, Division of Computational Biology, 6 Davis Drive, PO Box 12137, Research Triangle Park, North Carolina 27709-2137, USA

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Qiang Zhang Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina 27695-7566, USA
The Hamner Institutes for Health Sciences, CIIT Centers for Health Research, Division of Computational Biology, 6 Davis Drive, PO Box 12137, Research Triangle Park, North Carolina 27709-2137, USA

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Introduction Steroid hormone receptors (SHRs) comprise a superfamily of transcription factors that are activated by steroid hormones to regulate specific gene expression. They play critical roles in a variety of physiological

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Katherine A Leehy Department of Medicine and Pharmacology University of Minnesota Twin Cities Minneapolis, Minnesota, USA

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Tarah M Regan Anderson Department of Medicine and Pharmacology University of Minnesota Twin Cities Minneapolis, Minnesota, USA

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Andrea R Daniel Department of Medicine and Pharmacology University of Minnesota Twin Cities Minneapolis, Minnesota, USA

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Carol A Lange Department of Medicine and Pharmacology University of Minnesota Twin Cities Minneapolis, Minnesota, USA

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Julie H Ostrander Department of Medicine and Pharmacology University of Minnesota Twin Cities Minneapolis, Minnesota, USA

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Introduction Steroid hormone receptors (SRs) belong to the nuclear receptor superfamily of ligand-activated transcription factors. Members include the mineralocorticoid receptors, androgen receptors (ARs), estrogen receptors (ERs

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Susanne Arnold Faculty of Medicine, Institute for Neuroanatomy, RWTH Aachen University, 52074 Aachen, Germany

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Gilda Wright de Araújo Faculty of Medicine, Institute for Neuroanatomy, RWTH Aachen University, 52074 Aachen, Germany

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Cordian Beyer Faculty of Medicine, Institute for Neuroanatomy, RWTH Aachen University, 52074 Aachen, Germany

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, Arnold 2005 , Pawlak et al . 2005 , Garcia-Segura & Melcangi 2006 , Leonelli et al . 2007 ). Astrocyte mitochondria represent an interesting intracellular target organelle for steroid hormones, since they provide ample of services to neural cells

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Margaret Warner Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA

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Xiaotang Fan Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University, Chongqing, People’s Republic of China

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Anders Strom Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA

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Wanfu Wu Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA

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Jan-Åke Gustafsson Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden

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discoveries, the androgen receptor (AR) had not yet been cloned and the concept of steroid hormone receptors as a family of ligand-activated transcription factors was many years into the future. Cloning and nuclear receptors The advent of cloning in the

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M Tanaka Department of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan

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M Suzuki Department of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan

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T Kawana Department of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan

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M Segawa Department of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan

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M Yoshikawa Department of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan

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M Mori Department of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan

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M Kobayashi Department of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan

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N Nakai Department of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan

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T R Saito Department of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan

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( Pi et al. 2003 ). In the liver, the expression of the PRL-R gene is known to be regulated by sex steroid hormones; up-regulation by oestrogen and down-regulation by testosterone ( Jolicoeur et al. 1989 , Sakaguchi et al. 1994 ). However, the

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Vincent Giguère Goodman Cancer Institute, McGill University, Montréal, Quebec, Canada
Department of Biochemistry, McGill University, Montréal, Quebec, Canada

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Ronald M Evans The Salk Institute for Biological Studies, La Jolla, California, USA

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additional receptors related to these sequences, especially receptors for other cholesterol-derived steroid hormones such as progesterone, androgens, aldosterone, and vitamin D 3 . Low stringency homology screening led in rapid succession to the cloning of

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Fraydoon Rastinejad Metabolic Signaling and Disease Program, Sanford-Burnham Medical Research Institute, Orlando, Florida 32827, USA

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Pengxiang Huang Metabolic Signaling and Disease Program, Sanford-Burnham Medical Research Institute, Orlando, Florida 32827, USA

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Vikas Chandra Metabolic Signaling and Disease Program, Sanford-Burnham Medical Research Institute, Orlando, Florida 32827, USA

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Sepideh Khorasanizadeh Metabolic Signaling and Disease Program, Sanford-Burnham Medical Research Institute, Orlando, Florida 32827, USA

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factor HNF-4 is a novel member of the steroid hormone receptor superfamily . Genes and Development 4 2353 – 2365 . ( doi:10.1101/gad.4.12b.2353 ). Solomon IH Hager JM Safi R McDonnell DP Redinbo MR Ortlund EA 2005 Crystal structure of

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Shulin Zhang Department of Molecular and Medical Genetics, University of Toronto, Medical Sciences Building, 1 King’s College Circle, Toronto, Ontario, Canada M5S 1A8

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Melinda Chan Department of Molecular and Medical Genetics, University of Toronto, Medical Sciences Building, 1 King’s College Circle, Toronto, Ontario, Canada M5S 1A8

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Jane E Aubin Department of Molecular and Medical Genetics, University of Toronto, Medical Sciences Building, 1 King’s College Circle, Toronto, Ontario, Canada M5S 1A8

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2001 ), but the frequency of various monopotential versus bi- or multipotential cells in RC populations remains unknown. The steroid hormone 1,25-dihydroxyvitamin D3 (1,25(OH) 2 D 3 ) has diverse effects on many cell lineages, including

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