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incubated at 31 °C become females (female-producing temperature or FPT). The effect of the incubation temperature is only observed midway through development, also known as the temperature-sensitive period (TSP). Exogenous ligands (steroid hormones and
Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA
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Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA
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Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA
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Geriatric Research, Division of Endocrinology, Division of Gastroenterology and Hepatology, Department of Obstetrics and Gynecology, State Key Laboratory of Cellular Stress Biology, Program in Molecular Medicine, Education and Clinical Center (GRECC-182B), VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304, USA
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Introduction Extensive experimental evidence now indicates that aging in humans and animal models is associated with a general decline in steroid hormone production ( Zaidi et al . 2012 ). Similarly, a number of in vitro studies have clearly
The Hamner Institutes for Health Sciences, CIIT Centers for Health Research, Division of Computational Biology, 6 Davis Drive, PO Box 12137, Research Triangle Park, North Carolina 27709-2137, USA
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The Hamner Institutes for Health Sciences, CIIT Centers for Health Research, Division of Computational Biology, 6 Davis Drive, PO Box 12137, Research Triangle Park, North Carolina 27709-2137, USA
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The Hamner Institutes for Health Sciences, CIIT Centers for Health Research, Division of Computational Biology, 6 Davis Drive, PO Box 12137, Research Triangle Park, North Carolina 27709-2137, USA
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The Hamner Institutes for Health Sciences, CIIT Centers for Health Research, Division of Computational Biology, 6 Davis Drive, PO Box 12137, Research Triangle Park, North Carolina 27709-2137, USA
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Introduction Steroid hormone receptors (SHRs) comprise a superfamily of transcription factors that are activated by steroid hormones to regulate specific gene expression. They play critical roles in a variety of physiological
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Introduction Steroid hormone receptors (SRs) belong to the nuclear receptor superfamily of ligand-activated transcription factors. Members include the mineralocorticoid receptors, androgen receptors (ARs), estrogen receptors (ERs
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, Arnold 2005 , Pawlak et al . 2005 , Garcia-Segura & Melcangi 2006 , Leonelli et al . 2007 ). Astrocyte mitochondria represent an interesting intracellular target organelle for steroid hormones, since they provide ample of services to neural cells
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Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
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discoveries, the androgen receptor (AR) had not yet been cloned and the concept of steroid hormone receptors as a family of ligand-activated transcription factors was many years into the future. Cloning and nuclear receptors The advent of cloning in the
Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
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Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
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Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
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Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
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Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
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Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
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Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
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Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
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Department of Biochemistry, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Department of Laboratory Animal Sciences, Faculty of Veterinary Medicine, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180-8602, Japan
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( Pi et al. 2003 ). In the liver, the expression of the PRL-R gene is known to be regulated by sex steroid hormones; up-regulation by oestrogen and down-regulation by testosterone ( Jolicoeur et al. 1989 , Sakaguchi et al. 1994 ). However, the
Department of Biochemistry, McGill University, Montréal, Quebec, Canada
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additional receptors related to these sequences, especially receptors for other cholesterol-derived steroid hormones such as progesterone, androgens, aldosterone, and vitamin D 3 . Low stringency homology screening led in rapid succession to the cloning of
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factor HNF-4 is a novel member of the steroid hormone receptor superfamily . Genes and Development 4 2353 – 2365 . ( doi:10.1101/gad.4.12b.2353 ). Solomon IH Hager JM Safi R McDonnell DP Redinbo MR Ortlund EA 2005 Crystal structure of
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2001 ), but the frequency of various monopotential versus bi- or multipotential cells in RC populations remains unknown. The steroid hormone 1,25-dihydroxyvitamin D3 (1,25(OH) 2 D 3 ) has diverse effects on many cell lineages, including