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Introduction In teleosts, two major biologically active progestins, 17α,20β-dihydroxy-4-pregnen-3-one (17α,20β-DP, DHP) and 17,20β,21-trihydroxy-4-pregnen-3-one, have been identified and proved to be essential for spermatogenesis ( Schulz et al

Introduction Spermatogenesis is the development of the male gamete in the testis. It is a unique process in that there is an extended requirement for an active stem cell population that develops into morphologically distinctive motile

Introduction Spermatogenesis is a complex cellular development, in which spermatogonial stem cells (SSCs) give rise via mitosis to spermatogonia that enter meiosis and spermiogenesis to produce a large number of highly differentiated haploid

, Huhtaniemi 2006 ). By contrast, mice lacking LH or LH receptor (LuRKO) are sterile due to an arrest of spermatogenesis beyond the round spermatid stage ( Lei et al . 2001 , Zhang et al . 2001 , Kumar 2005 ). From these models, it is clear that FSH

Introduction The pituitary gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are the master regulators of spermatogenesis through the specific binding to their respective cognate receptors in the gonad, the FSH receptor

species. In this study, X. laevis was used for the first time as a comparative model to unravel the potential function of 5-α reductases on spermatogenesis in lower vertebrates. Material and methods Exposure X. laevis was taken from the breeding stock

Introduction Spermatogenesis is a process by which spermatogonia (diploid) undergo a series of events, including mitotic and meiotic divisions and morphological differentiation, to become haploid spermatozoa. During spermatogenesis, intricate

rate of apoptosis Histological examination of testes of 3- and 9-month-old mutant mice revealed no apparent abnormalities in their spermatogenesis (Fig. 2B and C ). However, in 3-month-old mutant mice, the average diameter of stage VII

Introduction The seminiferous epithelium supports the spermatogenesis which is a complex process leading to the formation of spermatozoa from spermatogonia. Tubules are composed by specific associations of germ cells and Sertoli cells, which

Introduction Spermatogenesis is the mechanism by which spermatogonium, a diploid cell, is transformed in spermatozoon, a highly differentiated haploid cell. This phenomenon takes place in the seminiferous tubules (ST) in which Sertoli cells support