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Gang Liu, Feng Luo, Qiang Song, Limin Wu, Yongxiu Qiu, Hongjuan Shi, Deshou Wang, and Linyan Zhou

Introduction In teleosts, two major biologically active progestins, 17α,20β-dihydroxy-4-pregnen-3-one (17α,20β-DP, DHP) and 17,20β,21-trihydroxy-4-pregnen-3-one, have been identified and proved to be essential for spermatogenesis ( Schulz et al

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Michael D Griswold

Introduction Spermatogenesis is the development of the male gamete in the testis. It is a unique process in that there is an extended requirement for an active stem cell population that develops into morphologically distinctive motile

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Luiz Henrique de Castro Assis, Rafael Henrique de Nóbrega, Nuria Esther Gómez-González, Jan Bogerd, and Rüdiger Winfried Schulz

Introduction Spermatogenesis is a complex cellular development, in which spermatogonial stem cells (SSCs) give rise via mitosis to spermatogonia that enter meiosis and spermiogenesis to produce a large number of highly differentiated haploid

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Elisabeth Sambroni, Antoine D Rolland, Jean-Jacques Lareyre, and Florence Le Gac

, Huhtaniemi 2006 ). By contrast, mice lacking LH or LH receptor (LuRKO) are sterile due to an arrest of spermatogenesis beyond the round spermatid stage ( Lei et al . 2001 , Zhang et al . 2001 , Kumar 2005 ). From these models, it is clear that FSH

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François Chauvigné, Cinta Zapater, Diego Crespo, Josep V Planas, and Joan Cerdà

Introduction The pituitary gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are the master regulators of spermatogenesis through the specific binding to their respective cognate receptors in the gonad, the FSH receptor

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R Urbatzka, B Watermann, I Lutz, and W Kloas

species. In this study, X. laevis was used for the first time as a comparative model to unravel the potential function of 5-α reductases on spermatogenesis in lower vertebrates. Material and methods Exposure X. laevis was taken from the breeding stock

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Wing-Yee Lui and Will M Lee

Introduction Spermatogenesis is a process by which spermatogonia (diploid) undergo a series of events, including mitotic and meiotic divisions and morphological differentiation, to become haploid spermatozoa. During spermatogenesis, intricate

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H Santti, L Mikkonen, A Anand, S Hirvonen-Santti, J Toppari, M Panhuysen, F Vauti, M Perera, G Corte, W Wurst, O A Jänne, and J J Palvimo

rate of apoptosis Histological examination of testes of 3- and 9-month-old mutant mice revealed no apparent abnormalities in their spermatogenesis (Fig. 2B and C ). However, in 3-month-old mutant mice, the average diameter of stage VII

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C Bois, C Delalande, M Nurmio, M Parvinen, L Zanatta, J Toppari, and S Carreau

Introduction The seminiferous epithelium supports the spermatogenesis which is a complex process leading to the formation of spermatozoa from spermatogonia. Tubules are composed by specific associations of germ cells and Sertoli cells, which

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Camille Bois, Christelle Delalande, Hélène Bouraïma-Lelong, Philippe Durand, and Serge Carreau

Introduction Spermatogenesis is the mechanism by which spermatogonium, a diploid cell, is transformed in spermatozoon, a highly differentiated haploid cell. This phenomenon takes place in the seminiferous tubules (ST) in which Sertoli cells support