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Pál Gyombolai, András D Tóth, Dániel Tímár, Gábor Turu and László Hunyady

Introduction Seven transmembrane receptors (7TMRs) constitute the largest family of plasma membrane receptors. Most of their intracellular effects are mediated via direct coupling to heterotrimeric G-proteins. To understand the molecular details of

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Tamar Eigler and Anat Ben-Shlomo

Introduction The anterior pituitary gland is subjected to the stimulatory and inhibitory effects of multiple regulators. Somatostatin (SRIF) and its cognate receptors (sst1–sst5) exhibit a dominant inhibitory role in pituitary gland regulation

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Chunmei Wang and Yong Xu

progesterone can bind to their nuclear receptors namely androgen receptors (ARs), estrogen receptors (ERs) and progesterone receptors, respectively, and these receptors function as transcription factors to regulate gene expression ( Yang & Shah 2014

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J Bian, X M Bai, Y L Zhao, L Zhang and Z J Liu

responsiveness to leptin may vary according to the metabolic conditions ( Widdowson et al . 1997 ) and leptin resistance is relevant to leptin receptors ( Lrb ) or their downstream signaling pathway ( Martin et al . 2000 ). Our previous studies showed that the

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J C R Cardoso, M S Clark, F A Viera, P D Bridge, A Gilles and D M Power

Introduction The G-protein-coupled receptors (GPCRs) are one of the largest known groups of proteins, comprising up to 80% of the total number of receptors identified in cells ( Bockaert 1991 , Bockaert et al. 2002 ). There are

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Marcel J M Schaaf

Introduction The nuclear receptor (NR) superfamily forms the largest family of transcription factors in metazoan organisms, in which they regulate reproduction, development, metabolism and the immune response ( Bookout et al . 2006 , Evans

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Hiroyuki Kaiya, Kenji Kangawa and Mikiya Miyazato

The discovery of growth hormone secretagogue receptor and its endogenous ligand, ghrelin, and ghrelin gene-derived peptides Most receptors for peptide hormones are G-protein-coupled receptors (GPCRs). There are still unidentified endogenous ligands

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Zsolt Csaba, Stéphane Peineau and Pascal Dournaud

Trafficking: what does it mean for somatostatin receptors? Receptor export along the secretory pathway represents the first event in the trafficking of receptors within the cell and influences the proper delivery of functional receptors at the

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David A Lovejoy, Belinda S W Chang, Nathan R Lovejoy and Jon del Castillo

Introduction The evolution of the corticotrophin-releasing hormone (CRH) family of peptides and their cognate receptors provides a model to understand peptide ligand and receptor co-evolution. Over the last few years with the acquisition of genomic

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Jun Yang and Morag J Young

Introduction The mineralocorticoid receptor (MR) is a nuclear receptor (NR) that is critical for controlling sodium and potassium transport in epithelial cells, most notably in the kidney and colon ( Pearce et al . 2003 ). It also plays important