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Jéssyca Aparecida Soares Giesen, Wender do Nascimento Rouver, Eduardo Damasceno Costa, Virgínia Soares Lemos and Roger Lyrio dos Santos

Progesterone seems to play a role in cardiovascular physiology since its receptors are expressed on endothelial cells from both sexes of mammals. However, little is known about its role on the coronary circulation. Thus, this study aims to evaluate the effect of acute administration of progesterone on the coronary bed and the endothelial pathways involved in this action in normotensive rats of both sexes. A dose–response curve of progesterone (1–50 μmol/L) in isolated hearts using the Langendorff preparation was performed. Baseline coronary perfusion pressure (CPP) was determined, and the vasoactive effect of progesterone was evaluated before and after infusion with Nω-nitro-L-arginine methyl ester (L-NAME), indomethacin, catalase, and Tiron. The analysis of nitric oxide (NO) and superoxide anion (O2 · ) was performed by DAF-2DA and DHE, respectively. Female group showed higher CPP. Nevertheless, progesterone promoted a similar relaxing response in both sexes. The use of L-NAME increased vasodilatory response in both sexes. When indomethacin was used, only the males showed a reduced relaxing response, and in the combined inhibition with L-NAME, indomethacin, and catalase, or with the use of Tiron, only the females presented reduced responses. NO and O2 ·− production has increased in female group, while the male group has increased only NO production. Our results suggest that progesterone is able to modulate vascular reactivity in coronary vascular bed with a vasodilatory response in both sexes. These effects seem to be, at least in part, mediated by different endothelial pathways, involving NO and EDH pathways in females and NO and prostanoids pathways in males.

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Hannah E Lapp, Andrew A Bartlett and Richard G Hunter

accumulation of reactive species in numerous stress-sensitive brain regions (e.g. cortex and hippocampus; Madrigal et al. 2001 , Rezin et al. 2008 , Gong et al. 2011 ). Indirectly, GR-dependent regulation of available glucose may contribute to the

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Jakob Bondo Hansen, Laila Romagueira Bichara Dos Santos, Ying Liu, Kacey J Prentice, Frederik Teudt, Morten Tonnesen, Jean-Christophe Jonas, Michael B Wheeler and Thomas Mandrup-Poulsen

673 – 681 . ( https://doi.org/10.2337/db07-1056 ) 10.2337/db07-1056 19073765 Lenzen S 2017 Chemistry and biology of reactive species with special reference to the antioxidative defence status in pancreatic beta-cells . Biochimica et Biophysica

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Alice Guyon and Jean-Louis Nahon

variety of deleterious events related to the production of reactive species, and pro-inflammatory prostaglandin and cytokines ( Vila et al. 2001 ). In this context, it was recently reported that SDF-1α expression was markedly increased in the reactive