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Mark Kidd, Geeta N Eick, Irvin M Modlin, Roswitha Pfragner, Manish C Champaneria, and John Murren

involved in secretory and proliferative regulation; (5) characterize serotonin secretion; and (6) investigate whether compounds with anti-proliferative effects in other neuroendocrine tumors, namely lanreotide ( Imam et al. 1997 ), rapamycin ( von Wichert

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Shalinee Dhayal, Francesco P Zummo, Matthew W Anderson, Patricia Thomas, Hannah J Welters, Catherine Arden, and Noel G Morgan

have suggested that this may occur as an early adaptive response designed to minimise the impact of lipotoxic stress ( Choi et al. 2009 ). In support of this they, and others, noted that palmitate-mediated cytotoxicity was attenuated by rapamycin, an

Open access

Oro Uchenunu, Michael Pollak, Ivan Topisirovic, and Laura Hulea

accompanied by reduced cell growth and proliferation via the MTORC1 (mechanistic/mammalian target of rapamycin complex 1) signaling pathway ( Shaw et al . 2004 a ). Consequently, the AMPK/MTORC1 signaling pathway links cellular energy status to mRNA

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David Finlay, Antonio J Ruiz-Alcaraz, Christopher Lipina, Stephane Perrier, and Calum Sutherland

-kinase (PI 3-kinase) to generate the second messenger phosphoinositide 3,4,5, trisphosphate (PIP3) ( Alessi & Downes 1998 , Cantley 2002 ), the stimulation of the nutrient sensing mammalian target of rapamycin (mTOR) pathway ( Raught et al. 2001

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Kelly León, Thomas Boulo, Astrid Musnier, Julia Morales, Christophe Gauthier, Laurence Dupuy, Steffen Heyne, Rolf Backofen, Anne Poupon, Patrick Cormier, Eric Reiter, and Pascale Crepieux

the phosphorylation of translation initiation and elongation factors as well as protein/protein interactions/dissociations occurring at the mRNA 5′ cap. Several of these regulatory steps depend on the mammalian target of rapamycin (mTOR) C1 complex

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Penny Ahlstrom, Esther Rai, Suharto Chakma, Hee Ho Cho, Palanivel Rengasamy, and Gary Sweeney

). Tunicamycin (Sigma-Aldrich) was dissolved in DMSO to a stock concentration of 5 mM. Rapamycin (Sigma-Aldrich) was dissolved in PBS to a stock concentration of 27.4 µM. Bafilomycin A1 (Sigma-Aldrich) was dissolved in DMSO to a stock concentration of 100 µM

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Philip A Gruppuso and Jennifer A Sanders

pathway for cellular growth, which involves the mechanistic target of rapamycin (mTOR) ( Laplante & Sabatini 2012 , Albert & Hall 2015 ). mTOR participates in two signaling complexes, mTORC1 and mTORC2. mTORC1, the canonical target of the

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Katherine A Robinson, Jonathan W Brock, and Maria G Buse

. 2000 ). We confirmed the observation ( Parikh et al . 2007 ) that high glucose induces Txnip expression, primarily via promoting transcription ( Minn et al . 2005 ). We further showed that rapamycin under most conditions decreased Txnip levels

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Guoqing Lei, Linxi Chen, Miao Peng, Bolin Zeng, Qiaoxi Yang, Hening Zhai, and Geyang Xu

). IFN-γ was from Sino Biological Inc. (Beijing, China). Rapamycin was purchased from Sigma Chemical Co.. Rabbit anti-Phospho-Stat3 (Tyr705), anti-Phospho-mTOR (Ser2448), anti-Phospho-p70 S6 Kinase (Thr389), anti-Phospho-S6 (Ser235/236), anti-mTOR, anti

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Bethany Hart, Elizabeth Morgan, and Emilyn U Alejandro

, which act in a coordinated way to regulate nutrient uptake and cellular signaling in response to maternal supply and fetal demand ( Jansson & Powell 2006 , Jansson et al . 2012 , Diaz et al . 2014 b ). Mechanistic target of rapamycin (mTOR) and O