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Viswanath Ragupathy, Wang Xue, Ji Tan, Krishnakumar Devadas, Yamei Gao and Indira Hewlett

progesterone-containing contraceptive use and risk of HIV-1 acquisition. A prospective study from seven African countries followed 2269 chronically HIV-1-infected women and showed no increased risk of HIV-1 disease progression for women on contraceptives

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Jéssyca Aparecida Soares Giesen, Wender do Nascimento Rouver, Eduardo Damasceno Costa, Virgínia Soares Lemos and Roger Lyrio dos Santos

Introduction Progesterone plays an important role in physiological processes in reproductive organs ( Morel et al. 2016 ). However, it is already known that it also acts on non-reproductive organs, such as the nervous system ( Rossetti et

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Caroline H Diep, Andrea R Daniel, Laura J Mauro, Todd P Knutson and Carol A Lange

Introduction Progesterone and progesterone receptors (PRs) are increasingly gaining attention for their emerging role as critical regulators of breast and gynecological cancers. With this newfound spotlight on PR action, there is an urgent need to

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Rosalia C M Simmen, Melissa E Heard, Angela M Simmen, Maria Theresa M Montales, Meera Marji, Samantha Scanlon and John Mark P Pabona

, including endometrial and cervical carcinoma, endometriosis, and leiomyoma, may arise post-puberty to further contribute to infertility. The steroid hormones estrogen and progesterone, working through their cognate nuclear receptors (estrogen receptor 1 (ESR

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Katarzyna Zielniok, Agnieszka Sobolewska and Małgorzata Gajewska

, galactopoiesis and involution. Ovarian steroids 17β-oestradiol (E2) and progesterone (P4) are significantly involved in coordination of the course of the lactation cycle. E2 and P4 mediate proliferative signals in mammary epithelial cells (MECs), and their

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Krisztina Pohóczky, József Kun, Bálint Szalontai, Éva Szőke, Éva Sághy, Maja Payrits, Béla Kajtár, Krisztina Kovács, József László Környei, János Garai, András Garami, Anikó Perkecz, Levente Czeglédi and Zsuzsanna Helyes

-selective agonist potency ( Barkhem et al . 1998 ). TRP channels have recently been described in the human endometrium, accompanied with estrogen/progesterone-induced decidualization, where the TRP canonical 1 (TRPC1) channel has been shown to be up-regulated in

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Gabriela Capllonch-Amer, Isabel Lladó, Ana M Proenza, Francisco J García-Palmer and Magdalena Gianotti

 h to a final concentration of 10 nM E 2 , 1 μM progesterone (Pg), and testosterone. When corresponded, 10 μM FLT, an androgen receptor (AR) blocker ( Labrie 1993 ), was added to the plate 1 h before Pg or testosterone. In sex hormone

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Silvia Giatti, Roberto Cosimo Melcangi and Marzia Pesaresi

Introduction An extensively demonstrated progesterone (PROG), produced in peripheral glands as well as directly in the nervous system ( Melcangi et al. 2008 , Porcu et al. 2016 ), exerts important effects in the neuroendocrine control of

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Andrea Romano, Bert Delvoux, Dagmar-Christiane Fischer and Patrick Groothuis

Introduction Progesterone, together with 17β-oestradiol, is a key regulator of cell proliferation and differentiation in the female genital tract. Altered responses to oestrogen and progesterone lead to steroid hormone

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Ruifang Yang, Xingji You, Xiaolu Tang, Lu Gao and Xin Ni

Introduction Progesterone, as its name implies is a progestation hormone. Early in human pregnancy, progesterone is produced mainly by the persistent corpus luteum. After about 6–8 weeks of pregnancy, luteal production of