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Douglas A Gibson, Ioannis Simitsidellis, and Philippa T K Saunders

with role for progestins in regulating the expression of AR ( Marshall et al . 2011 ). Following the establishment of pregnancy, immunohistochemistry studies have reported that AR is detected in decidual stromal cells and in endothelial cells lining

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Luca Clemente and Ian M Bird

Introduction Preeclampsia (PE) is a hypertensive disease of pregnancy that is both a leading cause of maternal morbidity and mortality worldwide and confers an increased risk for developing cardiovascular diseases later in life (reviewed by

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I Robertshaw, F Bian, and S K Das

.4% ( Boivin et al. 2007 ). Although much advancement has been made using assisted reproductive technologies (ARTs) to achieve higher pregnancy rates by improving the selection of high-quality embryos, the implantation process is still very illusive. The

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Hitoshi Iida, Takeshi Ogihara, Mun-kyeong Min, Akemi Hara, Yeong Gi Kim, Kyoko Fujimaki, Motoyuki Tamaki, Yoshio Fujitani, Hail Kim, and Hirotaka Watada

pancreas or islet transplantation would be an effective approach to augment β-cell mass, there is limited availability of pancreata for transplantation. Placental lactogens induce glucose intolerance during pregnancy, which leads to dramatic increases in

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Carolyn M Mitchell, Shane D Sykes, Xin Pan, Kirsty G Pringle, Eugenie R Lumbers, Jonathan J Hirst, and Tamas Zakar

pregnancy may cause serious complications such as preterm birth ( Marvin et al . 2002 , Shankar et al . 2010 ). The mechanisms that determine the timing of proinflammatory fetal membrane activation and the responsiveness of inflammatory genes to

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Jin Bai, Thomas J Lechuga, Joshua Makhoul, Hao Yan, Carol Major, Afshan Hameed, and Dong-bao Chen

Introduction Normal pregnancy is associated with profound uterine artery (UA) dilation exemplified by ~20- to 50-fold rises in uterine blood flow (UtBF) in late pregnant (P) vs nonpregnant (NP) state, which results in a large volume of

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L B James-Allan, G S Whitley, K Leslie, A E Wallace, and J E Cartwright

Introduction During the mid-secretory phase of the menstrual cycle, the human endometrium becomes remodelled due to rising levels of post-ovulatory progesterone, in preparation for pregnancy. A major part of this process is the differentiation

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Olivier Sandra, Isabelle Bataillon, Pascale Roux, Jacques Martal, Gilles Charpigny, Pierrette Reinaud, Philippe Bolifraud, Guy Germain, and Kaïs H Al-Gubory

Introduction A tightly regulated communication between the conceptus (the embryo or foetus and associated membranes) and the endometrium is necessary for the establishment and maintenance of pregnancy ( Paria et al. 2002 ). To be

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Philip Lowry and Russell Woods

Introduction The placenta is a consummate endocrine organ as it secretes many biologically active peptide hormones at various times throughout the whole pregnancy. Unlike regulated secretion from other endocrine tissues, secretion from the

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Michelle Colomiere, Michael Permezel, and Martha Lappas

Introduction The later part of normal human pregnancy is characterised by maternal hyperinsulinaemia and a progressive decline in insulin sensitivity, an adaptation required for adequate transport of nutrients between mother and foetus ( Buchanan