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Gerald Thiel, Isabelle Müller, and Oliver G Rössler

(ankyrin). Many biological functions have been connected with TRP channel activation, including regulation of Ca 2 + homeostasis, tumorigenesis, sensory temperature, and pain sensation. In pancreatic β-cells, several members of the TRP family of cation

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William J Stanley, Prerak M Trivedi, Andrew P Sutherland, Helen E Thomas, and Esteban N Gurzov

NOD8.3 CD8 + T-cells overnight at an effector:target ratio of 20:1. Result is representative of two independent experiments and shows 51 Cr release measurement in triplicate. Discussion Pancreatic β-cells are sensitive to the

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Zhipeng Li, Zhaoshui Shangguan, Yijie Liu, Jihua Wang, Xuejun Li, Shuyu Yang, and Suhuan Liu

potential regenerative influences of incretin therapy on preserving pancreatic β-cells are intriguing, the marked expansion of the exocrine and endocrine pancreatic compartments with the risk of carcinogenesis require more strict and convincing

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Laura Marroquí, Alejandro Gonzalez, Patricia Ñeco, Ernesto Caballero-Garrido, Elaine Vieira, Cristina Ripoll, Angel Nadal, and Ivan Quesada

Introduction A fine regulation of pancreatic β-cell function is essential for the control of plasma glucose homeostasis and nutrient metabolism. β-cell secretion and mass are dynamic features that adapt in the short and/or long term to the insulin

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Yu-Feng Zhao, Li Wang, Dingjun Zha, Li Qiao, Lianjun Lu, Jun Yu, Ping Qu, Qiang Sun, Jianhua Qiu, and Chen Chen

the GlaxoSmithKline chemical collection in 2006 ( Briscoe et al . 2006 ). In previous reports about FFARs actions on pancreatic β-cells, FFAs were commonly used as agonists of FFARs, but the effects of GW9508 on β-cell function were seldom reported

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K Lindberg, S G Rønn, D Tornehave, H Richter, J A Hansen, J Rømer, M Jackerott, and N Billestrup

Introduction Understanding the molecular mechanisms involved in pancreatic β-cell growth and differentiation is fundamental for developing novel strategies for the prevention and treatment of diabetes. This is the case for both type

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Cecilia Verga Falzacappa, Eleonora Petrucci, Valentina Patriarca, Simona Michienzi, Antonio Stigliano, Ercole Brunetti, Vincenzo Toscano, and Silvia Misiti

importance of Akt for regulation of β cell mass and function. In pancreatic β cells, PKB/ Akt can be activated by different factors, such as IGF-I and GLP-1 ( Giannoukakis et al. 2000 , Buteau et al. 2001 ), and it is directly activated by glucose

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Amanda M Ackermann and Maureen Gannon

Introduction An organism’s β-cell mass is determined by the number and the size of its pancreatic β-cells. This unique cell population is required for insulin production, which maintains glucose homeostasis. Diabetes is characterized

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Seisuke Sato, Hitomi Imachi, Jingya Lyu, Yumi Miyai, Kensaku Fukunaga, Tao Dong, Tomohiro Ibata, Toshihiro Kobayashi, Takuo Yoshimoto, Fumi Kikuchi, Kazuko Yonezaki, Nao Yamaji, Hisakazu Iwama, and Koji Murao

TNF-α played a role in impaired secretion of insulin, which frequently occurs in type 2 diabetes ( Donath et al. 2003 ). In pancreatic β-cells, TNF-α alone inhibited glucose-stimulated insulin secretion (GSIS) ( Zhang & Kim 1995 , Dunger et al

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Yu-Feng Zhao, Damien J Keating, Maria Hernandez, Dan Dan Feng, Yulong Zhu, and Chen Chen

Introduction Normal glucose homeostasis requires finely controlled orchestration of insulin secretion in response to subtle changes in blood glucose levels. Glucose-induced insulin secretion occurs when pancreatic β-cells utilize