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eating habits promote an exponential increase in obesity, which is associated with an array of metabolic complications (dyslipidemia, insulin resistance, and type 2 diabetes mellitus (T2DM)) that foster a significant risk for CV disease ( Poirier & Eckel

Introduction The prevalence of obesity and associated metabolic disorders has risen dramatically worldwide, resulting from chronic nutrient overload and sedentary behaviour ( Adams et al. 2006 ). Upon excess caloric intake, lipid deposition

Introduction The prevalence of overweight and obesity in the world has risen dramatically. Obesity is associated with significant metabolic disorders and may trigger severe cardiovascular diseases ( Piche et al. 2018 ). Among them

Introduction Obesity is now recognised to be a low-grade inflammatory condition in which dysregulated metabolism plays an integral role. In this review, we will describe how inflammatory mediators regulate aromatase expression in the human breast as

Introduction Obesity has become one of the most important health problems in the world. Except for some rare types of monogenic defects ( Farooqi & O'Rahilly 2006 ), obesity occurs due to the complex combination of multiple environmental and genetic

Introduction The rising pandemic of overweight and obesity has received major attention worldwide. Obesity is a major cause for the development of debilitating conditions such as type 2 diabetes, cardiovascular disease, hypertension, and non

Introduction Obesity is defined as the excessive accumulation of WAT. The role of sex hormones in obesity and disease has been recognized for decades ( Seidell et al. 1990 , Marin & Arver 1998 , Jones et al. 2000 , Cooke & Naaz 2004

Introduction A chronic imbalance between nutrient intake and energy expenditure leads to obesity, which is a major risk factor for a number of metabolic and vascular dysfunctions that include type 2 diabetes, cardiovascular disease

Introduction Obesity is becoming one of the major concerns of modern society for its increasingly economic burden and various associated metabolic disorders. Although the medical research has been achieved a great development in recent decades

, hyperandrogenemia, polycystic ovaries, and infertility ( Goodarzi et al . 2011 ). In most cases, PCOS also involves metabolic alterations such as insulin resistance (IR), hyperinsulinemia, dyslipidemia, and obesity. Additionally, we have recently revealed altered