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Ana Luísa Neves, João Coelho, Luciana Couto, Adelino Leite-Moreira and Roberto Roncon-Albuquerque Jr

eating habits promote an exponential increase in obesity, which is associated with an array of metabolic complications (dyslipidemia, insulin resistance, and type 2 diabetes mellitus (T2DM)) that foster a significant risk for CV disease ( Poirier & Eckel

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Yousheng Xu, Yongshun Wang, Jingjin Liu, Wei Cao, Lili Li, Hongwei Du, Enbo Zhan, Ruoxi Zhang, Huimin Liu, Maoen Xu, Tao Chen, Yilin Qu and Bo Yu

Introduction The prevalence of overweight and obesity in the world has risen dramatically. Obesity is associated with significant metabolic disorders and may trigger severe cardiovascular diseases ( Piche et al. 2018 ). Among them

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Evan R Simpson and Kristy A Brown

Introduction Obesity is now recognised to be a low-grade inflammatory condition in which dysregulated metabolism plays an integral role. In this review, we will describe how inflammatory mediators regulate aromatase expression in the human breast as

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J Bian, X M Bai, Y L Zhao, L Zhang and Z J Liu

Introduction Obesity has become one of the most important health problems in the world. Except for some rare types of monogenic defects ( Farooqi & O'Rahilly 2006 ), obesity occurs due to the complex combination of multiple environmental and genetic

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Lingxia Pang, Lianghui You, Chenbo Ji, Chunmei Shi, Ling Chen, Lei Yang, Fangyan Huang, Yahui Zhou, Jun Zhang, Xiaohui Chen and Xirong Guo

Introduction A chronic imbalance between nutrient intake and energy expenditure leads to obesity, which is a major risk factor for a number of metabolic and vascular dysfunctions that include type 2 diabetes, cardiovascular disease

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Yingkai Sun, Rui Wang, Shaoqian Zhao, Wen Li, Wen Liu, Lingyun Tang, Zhugang Wang, Weiqing Wang, Ruixin Liu, Guang Ning, Jiqiu Wang and Jie Hong

Introduction Obesity is becoming one of the major concerns of modern society for its increasingly economic burden and various associated metabolic disorders. Although the medical research has been achieved a great development in recent decades

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Xinwang Chen, Xiao Jia, Jie Qiao, Youfei Guan and Jihong Kang

, hyperandrogenemia, polycystic ovaries, and infertility ( Goodarzi et al . 2011 ). In most cases, PCOS also involves metabolic alterations such as insulin resistance (IR), hyperinsulinemia, dyslipidemia, and obesity. Additionally, we have recently revealed altered

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Ayse Basak Engin, Atilla Engin and Ipek Isik Gonul

Introduction Obesity is mainly dependent on excessive fat accumulation in the regional adipose tissues. In obese individuals, more adipocytes release more adipocytokines. Large breast volume is proportional to the fat storage in the visceral

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Rafaela Fadoni Alponti, Luciana Godoy Viana, Norma Yamanouye and Paulo Flavio Silveira

, insulin resistance in muscle and adipose tissues is a very common occurrence in obese ( Bonala et al . 2013 , Lo et al . 2013 ). This study aimed to identify whether intracellular traffic regulated by insulin in adipocytes from healthy (C), food

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H Roger Lijnen and Ilse Scroyen

. 2004 ), has the potential to affect glucose metabolism or adipose tissue-related angiogenesis and adiposity in mice with established obesity (which would be more clinically relevant). Materials and methods Male wild-type C57Bl/6 mice were generated in