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Raffaella Maria Gadaleta and Luca Magnani

Introduction/overview Nuclear receptors (NRs) are evolutionarily related DNA-binding transcription factors (TFs) ( Gronemeyer et al . 2004 , Chambon 2005 , Evans 2005 ). They regulate many aspects of mammalian physiology, including metabolism

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Tram B Doan, J Dinny Graham, and Christine L Clarke

currently face the challenge of living with advanced disease; therefore, there exists the need to develop rational treatments targeting these subgroups of breast cancer. Nuclear receptors (NRs) are potential promising targets due to the importance of NRs

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Weiwei Fan, Annette R Atkins, Ruth T Yu, Michael Downes, and Ronald M Evans

epigenetic changes, which are regulated by multiple signaling pathways ( Bassel-Duby & Olson 2006 , Barrès et al . 2012 ). In addition to the widely known calcineurin/NFAT and HDAC/MEF pathways, it has recently been shown that nuclear receptors (NRs) and

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Christopher J Millard, Peter J Watson, Louise Fairall, and John W R Schwabe

Historical perspective Nuclear receptors are a large family of DNA-binding transcription factors that are recruited to specific DNA sequences in the genome and regulate the expression of genes in the proximity (<1 million base pairs) of these sites

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Fraydoon Rastinejad, Pengxiang Huang, Vikas Chandra, and Sepideh Khorasanizadeh

Introduction As transcription factors, nuclear receptors (NRs) bind directly to lipophilic ligands, such as steroids, thyroid hormone, retinoids, and dietary lipids, and respond by regulating gene expression programs ( Mangelsdorf & Evans 1995

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Christopher E Wall, Ruth T Yu, Anne R Atkins, Michael Downes, and Ronald M Evans

al . 2013 ). Endurance training in skeletal muscle can be mechanistically linked to activation of an AMP-sensitive gene expression program coordinated by 5′-adenosine monophosphate-activated protein kinase (AMPK) and the nuclear receptor peroxisome

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Ann Louise Hunter, Natasha Narang, Matthew Baxter, David W Ray, and Toryn M Poolman

are especially marked when studying nuclear receptors, which may be highly dynamic, low-abundance proteins; we have encountered many such problems when studying the action of the glucocorticoid receptor (GR). The final amount of DNA from ChIP

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Francesco Paolo Zummo, Alexandre Berthier, Céline Gheeraert, Manjula Vinod, Marie Bobowski-Gérard, Olivier Molendi-Coste, Laurent Pineau, Matthieu Jung, Loic Guille, Julie Dubois-Chevalier, David Dombrowicz, Bart Staels, Jérôme Eeckhoute, and Philippe Lefebvre

blood, nutrients and oxygen flow, and centrifugal bile circulation ( Nagy et al. 2020 ). As sensors of the environment through their ability to bind hormones, metabolic intermediates or xenobiotics, nuclear receptors (NRs) are essential relays of

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Silvia Ottaviani, Alexander de Giorgio, Victoria Harding, Justin Stebbing, and Leandro Castellano

lncRNA binding various protein, DNA, and RNA substrates, to carry out specific functions in combination ( Guttman & Rinn 2012 , Mercer & Mattick 2013 ). Nuclear receptors (NRs) are ligand-activated transcription factors that regulate gene expression by

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Marcel J M Schaaf

Introduction The nuclear receptor (NR) superfamily forms the largest family of transcription factors in metazoan organisms, in which they regulate reproduction, development, metabolism and the immune response ( Bookout et al . 2006 , Evans