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Ting Yan, Wangwang Qiu, Jianlu Song, Youben Fan, and Zhili Yang

showed that ARHGAP36 promoted the proliferation and migration of PTC cells through related signaling pathways. These results suggest that ARHGAP36 can be used as a potential diagnostic marker and therapeutic target molecule for recurrence and

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Hanwei Cui, Qian Yi, Jianguo Feng, Li Yang, and Liling Tang

, such as promoting cell proliferation, migration and inhibition of apoptosis ( Li et al . 2007 , Vanamala et al . 2010 , Brisson & Barton 2012 ). In humans, the pre-mRNA of IGF1 can generate three isoforms, IGF1Ea, IGF1Eb and IGF1Ec, by alternative

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Lai Jin, Chuanhua Li, Rong Li, Zongxing Sun, Xianjun Fang, and Shengnan Li

−/−), had higher proliferation and migration rates compared with WT (CRH+/+) cells. In the prostate, cellular growth and differentiation are precisely regulated by autocrine and paracrine regulatory factors ( Cunha et al . 1987 ). Ectopic CRH, an endocrine

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Xiaoxia Che, Fangfang Jian, Chen Chen, Chang Liu, Gedan Liu, and Weiwei Feng

valuable. Herein, we show that serum derived exosomal miR-27a-5p from PCOS patients can be transferred to EC cell lines and thereby promote EC cells migration and invasion by targeting SMAD4. Therefore, miR-27a-5p from circulating exosomes from PCOS

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Yuan Pan, Chong Han, Chunlin Wang, Guohan Hu, Chun Luo, Xiaoqiang Gan, Fenglin Zhang, Yicheng Lu, and Xuehua Ding

signaling. These data indicate that ADAM10 is involved in pituitary adenoma invasiveness by affecting cell adhesion and migration by cleaving CD44 and L1, suggesting that ADAM10 could be a potential target for clinical therapy. Materials and methods

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Danrong Ye, Yang Jiang, Yihan Sun, Yuefeng Li, Yefeng Cai, Qingxuan Wang, Ouchen Wang, Endong Chen, and Xiaohua Zhang

consecutive days at 37°C with 5% CO 2 . Next, CCK-8 reagent (Beyotime, China) was added to each well, and the cells were incubated for 2 h, and absorbance at 450 nm was recorded. Cell migration and invasion assays For migration, transwell cell culture

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Ping Jiang, Jinwen Xu, Shuhui Zheng, Jinghe Huang, Qiuling Xiang, Xiaodong Fu, and Tinghuai Wang

are complex. One crucial mechanism is that MCP-1 recruits and enhances VSMC migration towards subendothelial area, thus accelerating the progression of atherosclerosis ( Spinetti et al . 2004 , Ma et al . 2007 ). In this regard, it has been reported

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Ralf Stumm and Volker Höllt

CXC chemokinereceptor 4 (CXCR4) regulates neuronal migration and axonal pathfinding The identification of molecules guiding neuronal migration and circuit formation during brain development is crucial for our understanding of brain

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S Hiraoka, H Ando, M Ban, H Ueda, and A Urano


We analyzed changes in the hypothalamic levels of vasotocin (VT) and isotocin (IT) mRNA in chum salmon during spawning migration to the Ishikari river. The fish were caught at Atsuta, a fisherman's village facing the Ishikari bay, and at Chitose, an upstream branch of the Ishikari river. The former are referred to as sea water (SW) fish, and the latter as freshwater (FW) fish. The levels of VT and IT mRNA in the forebrains were determined by quantitative Northern blot analysis using single-stranded DNA with the same mRNA sequences as the standards. Levels of VT mRNA were higher in the FW males than the FW females, although no such difference was seen in the SW fish. Changes in the levels of VT mRNA were markedly different in males and females. In the males, no significant differences were seen in the levels of VT-I and VT-II mRNA between the SW and FW fish. However, in the females, the levels of VT mRNA in the FW fish were significantly lower than those in the SW fish. Changes in the levels of IT-I and IT-II mRNA were essentially similar in the males and females. These results suggest that the control of VT gene expression is different in males and females during spawning migration, although the neuroendocrine mechanism is not known.

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Z Alourfi, R P Donn, A Stevens, A Berry, A McMaster, and D W Ray

Introduction Macrophage migration inhibitory factor (MIF) is a potent proinflammatory cytokine originally identified by its action on macrophages ( Bloom & Bennett 1966 , David 1966 ). Subsequently, it was cloned and found to be