to identify the signature proteins and their potential roles during the first 48 h of postpartum using the proteomics analysis. Materials and methods Animals and postpartum time intervals Pregnant wild-type mice (C57BL6/129SvEv; Charles
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Robert Lee Stanley, Takako Ohashi, Jacob Gordon, and Chishimba Nathan Mowa
Ilitch Aquino Marcondes-de-Castro, Thamiris Ferreira Oliveira, Renata Spezani, Thatiany Souza Marinho, Luiz Eduardo Macedo Cardoso, Marcia Barbosa Aguila, and Carlos Alberto Mandarim-de-Lacerda
. Epididymal WAT (eWAT) is located in the lower abdomen, connected to the epididymis, and suitable for evaluating cytokines and proinflammatory markers ( Mandarim-de-Lacerda et al. 2021 ). Therefore, eWAT is male mice’s most commonly studied visceral fat
Yousheng Xu, Yongshun Wang, Jingjin Liu, Wei Cao, Lili Li, Hongwei Du, Enbo Zhan, Ruoxi Zhang, Huimin Liu, Maoen Xu, Tao Chen, Yilin Qu, and Bo Yu
autotaxin mRNA levels were increased by about four-fold in db/db mice when compared to lean littermates ( Boucher et al. 2005 ). In contrast, depletion of autotaxin could protect against high-fat diet (HFD)-induced obesity, insulin resistance and glucose
J H Duncan Bassett and Graham R Williams
Introduction Thyroid hormone is essential for normal skeletal development and the maintenance of adult bone mass. Recent studies of T 3 receptor (TR) mutant mice have advanced our understanding and demonstrated the relevance of this field to
Carolina S Martinez, Verónica G Piazza, María E Díaz, Ravneet K Boparai, Oge Arum, María C Ramírez, Lorena González, Damasia Becú-Villalobos, Andrzej Bartke, Daniel Turyn, Johanna G Miquet, and Ana I Sotelo
FGF21 on body growth is evident in transgenic mice overexpressing this factor, which exhibit reduced growth, whereas targeted-disruption of FGF21 blunts food-restriction impairment of growth ( Inagaki et al . 2008 , Kubicky et al . 2012 ). Another
Lucia Kořínková, Martina Holubová, Barbora Neprašová, Lucie Hrubá, Veronika Pražienková, Michal Bencze, Martin Haluzík, Jaroslav Kuneš, Lenka Maletínská, and Blanka Železná
fa/fa rats lacking functional leptin receptor signaling, negligible PrRP mRNA expression was detected ( Ellacott et al . 2002 ). Leptin deficiency in ob/ob mice causes obesity based on hyperphagia and decreased energy expenditure; in addition
Xiaopan Yang, Xiaojing Fan, Jiangyue Feng, Tinghui Fan, Jingfei Li, Linfei Huang, Luming Wan, Huan Yang, Huilong Li, Jing Gong, Yanhong Zhang, Qi Gao, Fei Zheng, Lei Xu, Haotian Lin, Dandan Zhang, Hongbin Song, Yufei Wang, Xueping Ma, Zhiwei Sun, Cheng Cao, Xiaoli Yang, Hui Zhong, Yi Fang, and Congwen Wei
, we found that serum GP73 levels were significantly elevated in diabetic mice and humans and that blocking GP73 with a monoclonal antibody (mAb), siRNA knockdown, or genetic deficiency improved glucose homeostasis in streptozotocin (STZ)- and high
Xinran Hu, David Friedman, Salisha Hill, Richard Caprioli, Wendell Nicholson, Alvin C Powers, Lawrence Hunter, and Lee E Limbird
expressed in a FACS-purified rat β-cell population ( Chan et al. 1997 ), the lack of α 2 AR subtype-specific ligands has prevented definitive identification of the subtype involved in suppression of insulin release. The development of mice null for each
Sogol Gachkar, Sebastian Nock, Cathleen Geissler, Rebecca Oelkrug, Kornelia Johann, Julia Resch, Awahan Rahman, Anders Arner, Henriette Kirchner, and Jens Mittag
pathways. Materials and methods Experimental animals and treatment For all animal studies, C57BL/6 wild-type male mice (Charles River, Germany) at the age of 8–12 weeks were housed at ambient temperature (23°C) on a 12-h light/12-h dark cycle
Thomas P Meehan, Barry G Harmon, Megan E Overcast, Kristine K Yu, Sally A Camper, David Puett, and Prema Narayan
, unpublished observation). In order to determine if YHR was functional in vivo and to examine the physiological effects of chronic gonadotropin-mediated LHR activation, we have generated transgenic mice expressing YHR under the control of the mouse
