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Belinda J Petri Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine, Louisville, Kentucky, USA

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Carolyn M Klinge Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine, Louisville, Kentucky, USA
University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), Louisvillle, Kentucky, USA

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pseudouridine (Ψ) and 2′-O-methylation of the ribose (Am) ( Delaunay & Frye 2019 ). Mitochondrial-encoded rRNAs are also highly modified ( Laptev et al. 2020 ). There are 13 known internal mRNA modifications located in the 5’ and 3’ UTRs as well as exons and

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Junling Wang Gynecologic Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Hongyan Zhang Gynecologic Department, Hainan Traditional Chinese Medicine Hospital, Haikou, China

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Yue Cao Science and technology department, Guangzhou University of Chinese Medicine, Guangzhou, China

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Irene Ma Gynecologic Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Xuefang Liang Gynecologic Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Dongfang Xiang Gynecologic Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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postmenopausal OP by modulating various miRNAs ( Yu & Liu 2019 , Qiao et al. 2020 ). However, the specific functions and the intricacies of the regulatory network mechanisms involving circRNA–miRNA–mRNA in postmenopausal OP remain largely unexplored. To

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Yoshihiro Suzuki Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan

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Keiko Nakahara Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan

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Keisuke Maruyama Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan

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Rieko Okame Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan

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Takuya Ensho Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan

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Yoshiyuki Inoue Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan

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Noboru Murakami Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan

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tract nucleus (NTS) via the vagal afferent pathway ( Buyse et al . 2001 ). For hypophagia to occur, leptin increases the hypothalamic expression of POMC mRNA and decreases that of NPY and AgRP mRNAs ( Schwartz et al . 1996 , 1997 , Thornton et al

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Jan Christiansen Clinical Biochemistry, Departments of

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Astrid M Kolte Clinical Biochemistry, Departments of

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Thomas v O Hansen Clinical Biochemistry, Departments of

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Finn C Nielsen Clinical Biochemistry, Departments of

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Introduction Insulin-like growth factor 2 (IGF2) mRNA-binding protein 2 (IMP2/IGF2BP2) belongs to a family of mRNA-binding proteins (IMP1, IMP2, and IMP3) involved in RNA localization, stability, and translation. IMPs are mainly expressed during

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C Ruth González Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), School of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain
Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), School of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain

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María J Vázquez Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), School of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain
Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), School of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain

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Miguel López Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), School of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain
Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), School of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain

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Carlos Diéguez Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), School of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain
Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), School of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain

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energy balance, by assessing its mRNA levels in two different experimental paradigms, namely the effect of acute (fasting) and chronic (21 days) undernutrition in normal male rats. Furthermore, we evaluated the effect of leptin on GOAT expression in fed

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Ulas Ozkurede Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA

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Rishabh Kala Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA

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Cameron Johnson Department of Molecular, Cellular, and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA

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Ziqian Shen Department of Molecular, Cellular, and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA

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Richard A Miller Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
University of Michigan Geriatrics Center, Ann Arbor, Michigan, USA

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Gonzalo G Garcia Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA

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pregnancy-associated plasma protein-A-1-deficient mice (PKO mice) all show a reduction in mTORC1 activity ( Dominick et al. 2015 , 2017 ). Lower mTOR function diminishes cap-dependent mRNA translation; despite this, slow-aging endocrine mutant mice show

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J Shaik Mohamed Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, Texas 78373, USA

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Abby D Benninghoff Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, Texas 78373, USA

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G Joan Holt Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, Texas 78373, USA

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Izhar A Khan Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, Texas 78373, USA

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demonstrated impairment of GnRH and LH release, which can be reversed by exogenous administration of GnRH ( Colledge 2004 , Seminara et al. 2004 ). Moreover, GPR54 and GnRH mRNA expressions have been co-localized in the GnRH neurons in rat and a cichlid fish

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Cynthia S Ritter Renal Division, Washington University Medical School, Box 8126, 660 S. Euclid, St Louis, Missouri 63110, USA

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Sangeeta Pande Renal Division, Washington University Medical School, Box 8126, 660 S. Euclid, St Louis, Missouri 63110, USA

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Irina Krits Renal Division, Washington University Medical School, Box 8126, 660 S. Euclid, St Louis, Missouri 63110, USA

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Eduardo Slatopolsky Renal Division, Washington University Medical School, Box 8126, 660 S. Euclid, St Louis, Missouri 63110, USA

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Alex J Brown Renal Division, Washington University Medical School, Box 8126, 660 S. Euclid, St Louis, Missouri 63110, USA

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Ca suppresses the release of pre-packaged PTH and stimulates PTH peptide degradation ( Habener et al . 1975 ). In vivo studies have shown that dietary Ca can regulate PTH mRNA stability and parathyroid gland growth, but examination of the

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G Pelletier Oncology and Molecular Endocrinology Research Center, Centre de Recherche du Centre Hospitalier de l’Université Laval (CRCHUL), 2705, Laurier Boulevard, Québec, Québec GIV 4G2, Canada

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V Luu-The Oncology and Molecular Endocrinology Research Center, Centre de Recherche du Centre Hospitalier de l’Université Laval (CRCHUL), 2705, Laurier Boulevard, Québec, Québec GIV 4G2, Canada

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S Li Oncology and Molecular Endocrinology Research Center, Centre de Recherche du Centre Hospitalier de l’Université Laval (CRCHUL), 2705, Laurier Boulevard, Québec, Québec GIV 4G2, Canada

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L Ren Oncology and Molecular Endocrinology Research Center, Centre de Recherche du Centre Hospitalier de l’Université Laval (CRCHUL), 2705, Laurier Boulevard, Québec, Québec GIV 4G2, Canada

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F Labrie Oncology and Molecular Endocrinology Research Center, Centre de Recherche du Centre Hospitalier de l’Université Laval (CRCHUL), 2705, Laurier Boulevard, Québec, Québec GIV 4G2, Canada

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et al. 1992 , Lin et al. 1992 ). An analysis of the tissue distribution revealed the expression of 17β-HSD type 1 mRNA in steroidogenic as well as various other peripheral tissues, including the placenta, ovary, breast, endometrium, prostate, skin

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R Alhamdan Division of Child Health, Obstetrics and Gynaecology, University of Nottingham, Queen’s Medical Centre, Nottingham, UK

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W Maalouf Division of Child Health, Obstetrics and Gynaecology, University of Nottingham, Queen’s Medical Centre, Nottingham, UK

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B K Campbell Division of Child Health, Obstetrics and Gynaecology, University of Nottingham, Queen’s Medical Centre, Nottingham, UK

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J H Hernandez-Medrano Division of Child Health, Obstetrics and Gynaecology, University of Nottingham, Queen’s Medical Centre, Nottingham, UK

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P Marsters Division of Child Health, Obstetrics and Gynaecology, University of Nottingham, Queen’s Medical Centre, Nottingham, UK

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Natriuretic peptides (NPs) have been reported to have critical roles in follicular development and oocyte maturation in rodents. This study aimed to extend our current understanding of NP-mediated signalling pathways and mechanisms of action in the follicles of a monovulatory species. Ovine granulosa cells (GCs) and theca cells (TCs) were cultured under conditions designed to allow gonadotrophin-stimulated cell differentiation. Gene expression analysis was performed by qualitative (q)PCR for NPs and NPRs (between 16 and 96 h of culture) and VEGF 120 and VEGF 164 (between 16 and 144 h of culture). A qualitative analysis of the production of NP/NPR family members and NP ligand/receptor associations was carried out utilising a highly sensitive immunological approach known as ‘proximity ligation assay’ (PLA). All NPRs were observed in GCs, while NPRA was absent in TCs. In GCs, gene expression of NPRA, NPRB and NPRC was apparent but only active BNP and CNP and not ANP, were detected. Also in GCs, ANP but not CNP was able to significantly (P < 0.05) reduce oestradiol and increase (P < 0.05) progesterone. Inhibition of VEGF164 by ANP and CNP (P < 0.01) after 48 h of culture preceded up-regulation of VEGF120 by ANP (P < 0.01) after 144 h, but not CNP. Taken together, these findings appear to demonstrate that NP responsiveness in the GC compartment of sheep follicles is multi-facilitated, utilising both autocrine and paracrine stimulation pathways.

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