Search Results
Search for other papers by Belinda J Petri in
Google Scholar
PubMed
University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), Louisvillle, Kentucky, USA
Search for other papers by Carolyn M Klinge in
Google Scholar
PubMed
pseudouridine (Ψ) and 2′-O-methylation of the ribose (Am) ( Delaunay & Frye 2019 ). Mitochondrial-encoded rRNAs are also highly modified ( Laptev et al. 2020 ). There are 13 known internal mRNA modifications located in the 5’ and 3’ UTRs as well as exons and
Search for other papers by Junling Wang in
Google Scholar
PubMed
Search for other papers by Hongyan Zhang in
Google Scholar
PubMed
Search for other papers by Yue Cao in
Google Scholar
PubMed
Search for other papers by Irene Ma in
Google Scholar
PubMed
Search for other papers by Xuefang Liang in
Google Scholar
PubMed
Search for other papers by Dongfang Xiang in
Google Scholar
PubMed
postmenopausal OP by modulating various miRNAs ( Yu & Liu 2019 , Qiao et al. 2020 ). However, the specific functions and the intricacies of the regulatory network mechanisms involving circRNA–miRNA–mRNA in postmenopausal OP remain largely unexplored. To
Search for other papers by Yoshihiro Suzuki in
Google Scholar
PubMed
Search for other papers by Keiko Nakahara in
Google Scholar
PubMed
Search for other papers by Keisuke Maruyama in
Google Scholar
PubMed
Search for other papers by Rieko Okame in
Google Scholar
PubMed
Search for other papers by Takuya Ensho in
Google Scholar
PubMed
Search for other papers by Yoshiyuki Inoue in
Google Scholar
PubMed
Search for other papers by Noboru Murakami in
Google Scholar
PubMed
tract nucleus (NTS) via the vagal afferent pathway ( Buyse et al . 2001 ). For hypophagia to occur, leptin increases the hypothalamic expression of POMC mRNA and decreases that of NPY and AgRP mRNAs ( Schwartz et al . 1996 , 1997 , Thornton et al
Search for other papers by Jan Christiansen in
Google Scholar
PubMed
Search for other papers by Astrid M Kolte in
Google Scholar
PubMed
Search for other papers by Thomas v O Hansen in
Google Scholar
PubMed
Search for other papers by Finn C Nielsen in
Google Scholar
PubMed
Introduction Insulin-like growth factor 2 (IGF2) mRNA-binding protein 2 (IMP2/IGF2BP2) belongs to a family of mRNA-binding proteins (IMP1, IMP2, and IMP3) involved in RNA localization, stability, and translation. IMPs are mainly expressed during
Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), School of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain
Search for other papers by C Ruth González in
Google Scholar
PubMed
Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), School of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain
Search for other papers by María J Vázquez in
Google Scholar
PubMed
Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), School of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain
Search for other papers by Miguel López in
Google Scholar
PubMed
Department of Physiology, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), School of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain
Search for other papers by Carlos Diéguez in
Google Scholar
PubMed
energy balance, by assessing its mRNA levels in two different experimental paradigms, namely the effect of acute (fasting) and chronic (21 days) undernutrition in normal male rats. Furthermore, we evaluated the effect of leptin on GOAT expression in fed
Search for other papers by Ulas Ozkurede in
Google Scholar
PubMed
Search for other papers by Rishabh Kala in
Google Scholar
PubMed
Search for other papers by Cameron Johnson in
Google Scholar
PubMed
Search for other papers by Ziqian Shen in
Google Scholar
PubMed
University of Michigan Geriatrics Center, Ann Arbor, Michigan, USA
Search for other papers by Richard A Miller in
Google Scholar
PubMed
Search for other papers by Gonzalo G Garcia in
Google Scholar
PubMed
pregnancy-associated plasma protein-A-1-deficient mice (PKO mice) all show a reduction in mTORC1 activity ( Dominick et al. 2015 , 2017 ). Lower mTOR function diminishes cap-dependent mRNA translation; despite this, slow-aging endocrine mutant mice show
Search for other papers by J Shaik Mohamed in
Google Scholar
PubMed
Search for other papers by Abby D Benninghoff in
Google Scholar
PubMed
Search for other papers by G Joan Holt in
Google Scholar
PubMed
Search for other papers by Izhar A Khan in
Google Scholar
PubMed
demonstrated impairment of GnRH and LH release, which can be reversed by exogenous administration of GnRH ( Colledge 2004 , Seminara et al. 2004 ). Moreover, GPR54 and GnRH mRNA expressions have been co-localized in the GnRH neurons in rat and a cichlid fish
Search for other papers by Cynthia S Ritter in
Google Scholar
PubMed
Search for other papers by Sangeeta Pande in
Google Scholar
PubMed
Search for other papers by Irina Krits in
Google Scholar
PubMed
Search for other papers by Eduardo Slatopolsky in
Google Scholar
PubMed
Search for other papers by Alex J Brown in
Google Scholar
PubMed
Ca suppresses the release of pre-packaged PTH and stimulates PTH peptide degradation ( Habener et al . 1975 ). In vivo studies have shown that dietary Ca can regulate PTH mRNA stability and parathyroid gland growth, but examination of the
Search for other papers by G Pelletier in
Google Scholar
PubMed
Search for other papers by V Luu-The in
Google Scholar
PubMed
Search for other papers by S Li in
Google Scholar
PubMed
Search for other papers by L Ren in
Google Scholar
PubMed
Search for other papers by F Labrie in
Google Scholar
PubMed
et al. 1992 , Lin et al. 1992 ). An analysis of the tissue distribution revealed the expression of 17β-HSD type 1 mRNA in steroidogenic as well as various other peripheral tissues, including the placenta, ovary, breast, endometrium, prostate, skin
Search for other papers by R Alhamdan in
Google Scholar
PubMed
Search for other papers by W Maalouf in
Google Scholar
PubMed
Search for other papers by B K Campbell in
Google Scholar
PubMed
Search for other papers by J H Hernandez-Medrano in
Google Scholar
PubMed
Search for other papers by P Marsters in
Google Scholar
PubMed
Natriuretic peptides (NPs) have been reported to have critical roles in follicular development and oocyte maturation in rodents. This study aimed to extend our current understanding of NP-mediated signalling pathways and mechanisms of action in the follicles of a monovulatory species. Ovine granulosa cells (GCs) and theca cells (TCs) were cultured under conditions designed to allow gonadotrophin-stimulated cell differentiation. Gene expression analysis was performed by qualitative (q)PCR for NPs and NPRs (between 16 and 96 h of culture) and VEGF 120 and VEGF 164 (between 16 and 144 h of culture). A qualitative analysis of the production of NP/NPR family members and NP ligand/receptor associations was carried out utilising a highly sensitive immunological approach known as ‘proximity ligation assay’ (PLA). All NPRs were observed in GCs, while NPRA was absent in TCs. In GCs, gene expression of NPRA, NPRB and NPRC was apparent but only active BNP and CNP and not ANP, were detected. Also in GCs, ANP but not CNP was able to significantly (P < 0.05) reduce oestradiol and increase (P < 0.05) progesterone. Inhibition of VEGF164 by ANP and CNP (P < 0.01) after 48 h of culture preceded up-regulation of VEGF120 by ANP (P < 0.01) after 144 h, but not CNP. Taken together, these findings appear to demonstrate that NP responsiveness in the GC compartment of sheep follicles is multi-facilitated, utilising both autocrine and paracrine stimulation pathways.