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Peng Zhang, Sheng Wang, Liang Wang, Bing Chen Shan, Hui Zhang, Fan Yang, Zhi Qiang Zhou, Xiao Wang, Ye Yuan and You Jia Xu

Introduction Hepcidin is a small peptide hormone that is synthesized and secreted by the liver and regulates iron metabolism ( Zhao et al . 2013 ). Hepcidin acts by binding to the ferroportin iron exporter, which triggers its internalization

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S Lortz, S Schröter, V Stückemann, I Mehmeti and S Lenzen

DL Mandrup-Poulsen T 2001 A choice of death – the signal-transduction of immune-mediated β-cell apoptosis . Diabetologia 44 2115 – 2133 . ( doi:10.1007/s001250100021 ). Fahmy M Young SP 1993 Modulation of iron metabolism in monocyte

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Xin Jiang, Heyang Wang, Wencai Shi, Zhilei Shen, Hui Shen and Min Li

Leibold EA 2012 Mammalian iron metabolism and its control by iron regulatory proteins . Biochimica et Biophysica Acta 1823 1468 – 1483 . ( doi:10.1016/j.bbamcr.2012.05.010 ). Andrews NC Schmidt PJ 2007 Iron homeostasis . Annual Review

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Matthew L Rise, Susan E Douglas, Dionne Sakhrani, Jason Williams, K Vanya Ewart, Marlies Rise, William S Davidson, Ben F Koop and Robert H Devlin

( Wang et al. 1999 , Kneussel & Betz 2000 , Stangler et al. 2002 ). GABARAP binds transferrin receptor (TfR) and potentially plays a role in trafficking or cycling of TfR ( Green et al. 2002 ). Liver TfR plays a key role in iron metabolism

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Edward T Bagu and Manuela M Santos

-Guillouzo C Brissot P 2002 C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism . Journal of Biological Chemistry 277 41163 – 41170

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H Tokuda, K Kato, H Natsume, A Kondo, G Kuroyanagi, R Matsushima-Nishiwaki, Y Ito, T Otsuka and O Kozawa

and iron metabolism . Nature Chemical Biology 4 33 – 41 . doi:10.1038/nchembio.2007.54 . Zhou G Myers R Li Y Chen Y Shen X Fenyk-Melody J Wu M Ventre J Doebber T Fujii N 2001 Role of AMP-activated protein kinase in

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Jakob Bondo Hansen, Laila Romagueira Bichara Dos Santos, Ying Liu, Kacey J Prentice, Frederik Teudt, Morten Tonnesen, Jean-Christophe Jonas, Michael B Wheeler and Thomas Mandrup-Poulsen

GLT specifically alters the iron metabolism in beta-cells both in vivo and in vitro resulting in apoptosis. GLT induced Dmt1 and Trfr mRNA upregulation in beta-cells, and this was associated with increased iron uptake, increased intracellular

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Michel Chrétien and Majambu Mbikay

diabetes ( Zheng et al. 2012 , Nead et al. 2015 ); furin in atherosclerosis ( Turpeinen et al. 2011 ); PC5/6 and mostly PCSK9 in cholesterol metabolism ( Iatan et al. 2009 , Wu & Li 2014 , a review); PC7 in iron metabolism ( Oexle et al. 2011

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Emily Tubbs and Jennifer Rieusset

of the ER-MT cross-talk . Current Alzheimer Research 12 655 – 672 . ( doi:10.2174/1567205012666150710095035 ) Wang J Pantopoulos K 2011 Regulation of cellular iron metabolism . Biochemical Journal 434 365 – 381 . ( doi:10