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proximal tubules ( Ide et al. 2016 ). Likewise, conditional ablation of Fgfr1 in the distal tubule ( Ksp-Cre ) caused hypophosphatemia and hypercalciuria whereas ablation in the proximal tubule ( gGt-Cre ) resulted in hyperphosphatemia ( Fig. 2B ). At

pathway. Precise knowledge of the mechanisms underlying the long-term and the putative short-term regulations of Pi homeostasis is crucial to propose an appropriate clinical response in relevant disease states. A persistent hyperphosphatemia has very

, hypercalcemia, and hyperphosphatemia ( Kuro-o et al . 1997 , Yoshida et al . 2002 ). However, Honda et al . (1999) have documented that renal Stc2 mRNA expression is reduced by calcitriol, the active form of vitamin D 3 , in rats. Thus, the regulatory

Hyperostosis-hyperphosphatemia syndrome: a congenital disorder of O-glycosylation associated with augmented processing of fibroblast growth factor 23 . Journal of Bone and Mineral Research 22 235 – 242 . ( https://doi.org/10.1359/jbmr.061105 ) Fukumoto

) type-I ( Albright et al . 1942 , Chase et al . 1969 ). Hypocalcemia and hyperphosphatemia with elevated PTH levels are the typical biochemical features of PHP type-I. Only mutations on the maternal allele cause PTH resistance, owing to the silencing

concentrations are inappropriately low in 76% of patients and normal in 24% of patients. Other biochemical features of ADH1 include hyperphosphatemia, hypomagnesemia and hypercalciuria ( Hannan & Thakker 2013 , Roszko et al. 2016 ). Most ADH1 patients have a

). A similar case has been reported by Dianatfar et al. (2021) . Both studies ruled out the possible etiologies for hypoparathyroidism and finally suggested that hypoparathyroidism and hyperphosphatemia could have occurred secondary to COVID-19

. 2004 , Yu & White 2005 ). Conversely, mice with deletions in Fgf23 show hyperphosphatemia, ectopic mineralization, and poorly formed skeletons with an extremely low PTH level and an elevated 1,25(OH) 2 vitamin D 3 level ( Liu et al . 2006 ). Fgf23