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Stefania Carobbio Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK
Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK

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Barry Rosen Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK

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Antonio Vidal-Puig Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK
Wellcome Trust Sanger Institute, Metabolic Research Laboratories, Wellcome Trust Genome Campus, Hinxton, UK

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pluripotent human stem cells. Generation of multipotent MPCs from human stem cells Protocols developed for the differentiation of hIPS/ES cells into fully differentiated and functional cells from all three embryonic germ layers can involve a combination of

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Suzy Markossian Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, CNRS, INRA, École Normale Supérieure de Lyon, Lyon Cedex 07, France

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Frédéric Flamant Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, CNRS, INRA, École Normale Supérieure de Lyon, Lyon Cedex 07, France

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, including human stem cells 2013 Cong et al . (2013) , Mali et al . (2013 b ) CRISPR/Cas9 genome editing in mice 2013 Mashiko et al . (2013) , Yang et al . (2013 a ) CRISPR/Cas9 genome editing in pigs and monkeys 2013 Niu et al

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Nikoletta G Papadopoulou Departments of Pharmacology and Experimental Therapeutics,
Biochemistry and
Internal Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Department of Obstetrics and Gynecology, Tufts-New England Medical Center, Boston, MA 02111, USA

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Lauren Oleson Departments of Pharmacology and Experimental Therapeutics,
Biochemistry and
Internal Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Department of Obstetrics and Gynecology, Tufts-New England Medical Center, Boston, MA 02111, USA

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Duraisamy Kempuraj Departments of Pharmacology and Experimental Therapeutics,
Biochemistry and
Internal Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Department of Obstetrics and Gynecology, Tufts-New England Medical Center, Boston, MA 02111, USA

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Jill Donelan Departments of Pharmacology and Experimental Therapeutics,
Biochemistry and
Internal Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Department of Obstetrics and Gynecology, Tufts-New England Medical Center, Boston, MA 02111, USA

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Curtis L Cetrulo Departments of Pharmacology and Experimental Therapeutics,
Biochemistry and
Internal Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Department of Obstetrics and Gynecology, Tufts-New England Medical Center, Boston, MA 02111, USA

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Theoharis C Theoharides Departments of Pharmacology and Experimental Therapeutics,
Biochemistry and
Internal Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Department of Obstetrics and Gynecology, Tufts-New England Medical Center, Boston, MA 02111, USA

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and respond to these peptides ( Kempuraj et al. 2004 ). Here, we show for the first time that hCBMCs upregulate only CRH-R2 in response to IL-1, IL-4 and LPS. Materials and methods Recombinant human stem cell factor

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Kazuma Saito Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan
Department of Ophthalmology, Gunma University Graduate School of Medicine, Maebashi, Japan

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Kazuhiko Horiguchi Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan

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Sayaka Yamada Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan

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Battsetseg Buyandalai Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan

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Emi Ishida Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan

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Shunichi Matsumoto Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan

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Satoshi Yoshino Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan

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Yasuyo Nakajima Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan

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Eijiro Yamada Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan

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Tsugumichi Saito Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan

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Atsushi Ozawa Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan

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Yuki Tajika Department of Anatomy, Gunma University Graduate School of Medicine, Maebashi, Japan

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Hideo Akiyama Department of Ophthalmology, Gunma University Graduate School of Medicine, Maebashi, Japan

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Masanobu Yamada Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan

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.1073/pnas.77.7.4345 McNerney C Johnston Jr RJ 2021 Thyroid hormone signaling specifies cone photoreceptor subtypes during eye development: insights from model organisms and human stem cell-derived retinal organoids . Vitamins and Hormones 116 51 – 90

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Yingdi Yuan Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
Department of Pediatrics, The First People’s Hospital of Lianyungang, Xuzhou Medical University Affiliated Hospital of Lianyungang (Lianyungang Clinical College of Nanjing Medical University), Lianyungang, China

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Xinguo Cao Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
Cancer Care Ontario, Toronto, Canada

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Jiaojiao Hu Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Jingyun Li Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Dan Shen Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Lianghui You Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Xianwei Cui Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Xing Wang Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Yahui Zhou Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Yao Gao Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Lijun Zhu Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Pengfei Xu Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Chenbo Ji Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Xirong Guo Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Juan Wen Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Aizawa Y 2009 Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation . Nucleic Acids Research 37 4987 – 5000 . ( https://doi.org/10.1093/nar/gkp426 ) 19531736 10.1093/nar/gkp426 Kornfeld JW

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Maria Jacoba Kruger Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

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Maria Martha Conradie Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

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Magda Conradie Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

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Mari van de Vyver Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

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. Stem Cells and Development 20 1297 – 1308 . ( https://doi.org/10.1089/scd.2010.0466 ) 10.1089/scd.2010.0466 Rentoukas E Tsarouhas K Kaplanis I Korou E Nikolaou M Marathonitis G Kokkinou S Haliassos A Mamalaki A Kouretas D , 2012 Connection

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Jing Lu Beijing Key Laboratory of Diabetes Research and Care, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Cheng Cheng Beijing Key Laboratory of Diabetes Research and Care, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Zhen-Chao Cheng Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing, China
BeiJing School, Beijing, China

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Qian Wu Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing, China
HangZhou XueJun High School, Hangzhou, China

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Han Shen Beijing Key Laboratory of Diabetes Research and Care, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Ming-xia Yuan Beijing Key Laboratory of Diabetes Research and Care, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Bo Zhang Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing, China

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Jin-Kui Yang Beijing Key Laboratory of Diabetes Research and Care, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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-induced insulin secretion . Molecular Endocrinology 26 696– 709 . ( https://doi.org/10.1210/me.2011-1256 ) Hrvatin S O’Donnell CW Deng F Millman JR Pagliuca FW Diiorio P Rezania A Gifford DK Melton DA 2014 Differentiated human stem cells

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Flavia Giannone
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Giorgio Malpeli Department of Experimental Medicine, Section of Hematology, Section of Anatomic Pathology, Section of Immunology, University of Milano-Bicocca, Monza 20052, Italy

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Veronica Lisi Department of Experimental Medicine, Section of Hematology, Section of Anatomic Pathology, Section of Immunology, University of Milano-Bicocca, Monza 20052, Italy

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Silvia Grasso Department of Experimental Medicine, Section of Hematology, Section of Anatomic Pathology, Section of Immunology, University of Milano-Bicocca, Monza 20052, Italy

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Priyanka Shukla Department of Experimental Medicine, Section of Hematology, Section of Anatomic Pathology, Section of Immunology, University of Milano-Bicocca, Monza 20052, Italy

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Dunia Ramarli Department of Experimental Medicine, Section of Hematology, Section of Anatomic Pathology, Section of Immunology, University of Milano-Bicocca, Monza 20052, Italy

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Silvia Sartoris Department of Experimental Medicine, Section of Hematology, Section of Anatomic Pathology, Section of Immunology, University of Milano-Bicocca, Monza 20052, Italy

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Vladia Monsurró Department of Experimental Medicine, Section of Hematology, Section of Anatomic Pathology, Section of Immunology, University of Milano-Bicocca, Monza 20052, Italy

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Mauro Krampera Department of Experimental Medicine, Section of Hematology, Section of Anatomic Pathology, Section of Immunology, University of Milano-Bicocca, Monza 20052, Italy

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Eliana Amato Department of Experimental Medicine, Section of Hematology, Section of Anatomic Pathology, Section of Immunology, University of Milano-Bicocca, Monza 20052, Italy

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Giuseppe Tridente Department of Experimental Medicine, Section of Hematology, Section of Anatomic Pathology, Section of Immunology, University of Milano-Bicocca, Monza 20052, Italy

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Marco Colombatti Department of Experimental Medicine, Section of Hematology, Section of Anatomic Pathology, Section of Immunology, University of Milano-Bicocca, Monza 20052, Italy

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Marco Parenti
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Giulio Innamorati Department of Experimental Medicine, Section of Hematology, Section of Anatomic Pathology, Section of Immunology, University of Milano-Bicocca, Monza 20052, Italy

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Haemostasis 86 1106 – 1113 . den Dekker E Molin DG Breikers G van Oerle R Akkerman JW van Eys GJ Heemskerk JW 2001b Expression of transient receptor potential mRNA isoforms and Ca(2+) influx in differentiating human stem cells and

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Gemma Tan Department of Anatomy and Developmental Biology, Murdoch Childrens Research Institute, Department of Paediatrics, Monash University, Building 73, Clayton, Victoria 3800, Australia
Department of Anatomy and Developmental Biology, Murdoch Childrens Research Institute, Department of Paediatrics, Monash University, Building 73, Clayton, Victoria 3800, Australia

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Andrew G Elefanty Department of Anatomy and Developmental Biology, Murdoch Childrens Research Institute, Department of Paediatrics, Monash University, Building 73, Clayton, Victoria 3800, Australia
Department of Anatomy and Developmental Biology, Murdoch Childrens Research Institute, Department of Paediatrics, Monash University, Building 73, Clayton, Victoria 3800, Australia
Department of Anatomy and Developmental Biology, Murdoch Childrens Research Institute, Department of Paediatrics, Monash University, Building 73, Clayton, Victoria 3800, Australia

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Edouard G Stanley Department of Anatomy and Developmental Biology, Murdoch Childrens Research Institute, Department of Paediatrics, Monash University, Building 73, Clayton, Victoria 3800, Australia
Department of Anatomy and Developmental Biology, Murdoch Childrens Research Institute, Department of Paediatrics, Monash University, Building 73, Clayton, Victoria 3800, Australia
Department of Anatomy and Developmental Biology, Murdoch Childrens Research Institute, Department of Paediatrics, Monash University, Building 73, Clayton, Victoria 3800, Australia

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. Hrvatin S O'Donnell CW Deng F Millman JR Pagliuca FW DiIorio P Rezania A Gifford DK Melton DA 2014 Differentiated human stem cells resemble fetal, not adult, β cells . PNAS 111

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Carlos Larqué Department of Neurodevelopment and Physiology, Neuroscience Division, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico

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Myrian Velasco Department of Neurodevelopment and Physiology, Neuroscience Division, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico

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Francisco Barajas-Olmos Immunogenomics and Metabolic Disease Laboratory, Instituto Nacional de Medicina Genómica, SS, Mexico City, Mexico

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Neyvis García-Delgado Department of Neurodevelopment and Physiology, Neuroscience Division, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico

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Juan Pablo Chávez-Maldonado Department of Neurodevelopment and Physiology, Neuroscience Division, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico

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Jazmín García-Morales Department of Neurodevelopment and Physiology, Neuroscience Division, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico

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Lorena Orozco Immunogenomics and Metabolic Disease Laboratory, Instituto Nacional de Medicina Genómica, SS, Mexico City, Mexico

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Marcia Hiriart Department of Neurodevelopment and Physiology, Neuroscience Division, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico

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Melton DA 2014 Differentiated human stem cells resemble fetal, not adult, beta cells . PNAS 111 3038 – 3043 . ( doi:10.1073/pnas.1400709111 ) Jermendy A Toschi E Aye T Koh A Aguayo-Mazzucato C Sharma A Weir GC Sgroi D Bonner

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