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Franziska Boess, Cristina Bertinetti-Lapatki, Sannah Zoffmann, Catherine George, Thomas Pfister, Adrian Roth, Serene M L Lee, Wolfgang E Thasler, Thomas Singer and Laura Suter

, there is only inconclusive evidence indicating that GLP1R agonists may cause C-cell carcinomas in primates; in particular, as expression of GLP1R in healthy human thyroids is still a matter of debate. Indeed, based on a group of patients with several

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Nils Wierup, Frank Sundler and R Scott Heller

the almost one and a half centuries that have passed since the islets were first discovered, several islet cell types have been described in different mammalian species and at different stages of development. In adult humans, the islets have until

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Yuumi Ishizuka, Kazuhiro Nakayama, Ayumi Ogawa, Saho Makishima, Supichaya Boonvisut, Atsushi Hirao, Yusaku Iwasaki, Toshihiko Yada, Yoshiko Yanagisawa, Hiroshi Miyashita, Masafumi Takahashi, Sadahiko Iwamoto and Jichi Medical University Promotion Team of a Large-Scale Human Genome Bank for All over Japan

levels under still excessive human TRIB1 mRNA levels ( Supplementary Fig. 1A and B ). Figure 4 Studies of molecular interaction of TRIB1 with CEBPA, CEBPB, and MLXIPL. Constructs of MLXIPL mutants. NLS, nuclear localization signal; bHLH, basic helix

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Sofia A Rahman, Azizun Nessa and Khalid Hussain

Harries LW Gloyn AL Ellard S 2009 Update of mutations in the genes encoding the pancreatic beta-cell K ATP channel subunits Kir6.2 ( KCNJ11 ) and sulfonylurea receptor 1 ( ABCC8 ) in diabetes mellitus and hyperinsulinism . Human Mutation 30

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Magdalene O Wilson, Kathleen T Scougall, Jarupa Ratanamart, Elizabeth A McIntyre and James A M Shaw

immunosuppressant drugs, limited availability of human cadaveric tissue precludes wider implementation. For these reasons genetic engineering approaches to the treatment of both Type 1 and Type 2 diabetes mellitus are being explored ( Shaw & Docherty 2002

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Antonella Barreca, Elena Lasorsa, Ludovica Riera, Rodolfo Machiorlatti, Roberto Piva, Maurilio Ponzoni, Ivo Kwee, Francesco Bertoni, Pier Paolo Piccaluga, Stefano A Pileri, Giorgio Inghirami and The European T-Cell Lymphoma Study Group

LH Weiss LM 1996 Detection of the t(2;5)(p23;q35) chromosomal translocation in large B-cell lymphomas other than anaplastic large cell lymphoma . Human Pathology 27 590 – 594 . doi:10.1016/S0046-8177(96)90167-7 . Bai RY Dieter P Peschel

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Luca Persani, Raffaella Rossetti and Chiara Cacciatore

indicates the essential role played by X-linked genes in ovarian function. Furthermore, the genetic origin of POI is supported by the existence of monogenic forms in humans and animal models indicating also the relevance of non-X genetic loci for POI

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Fabien Duval, Esther Dos Santos, Hadia Moindjie, Valérie Serazin, Nelly Swierkowski-Blanchard, François Vialard and Marie-Noëlle Dieudonné

Introduction Human embryo implantation is a multi-step process that begins with apposition of trophoblastic cells from a competent blastocyst to the maternal endometrium. This apposition occurs during the ‘window of implantation’, a short

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S Dubois, A M Madec, A Mesnier, M Armanet, K Chikh, T Berney and Ch Thivolet

depend on graft vascular density and blood flow ( Olsson & Carlsson 2006 ). The present study aimed to investigate the effects of glucose on human β-cell function and endothelial cells. Materials and methods Subjects Human pancreatic islets from eight

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Philip W Peake, Jaquelyne T Hughes, Yvonne Shen and John A Charlesworth

present in bovine and mouse plasma adiponectin is sialic acid, possibly on O-linked glycans ( Sato et al. 2001 ). However, the function of this modification has not been determined. Mutant forms of recombinant human adiponectin expressed in a