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Feng Wang, Lu Wang, Yifeng Wang, Dai Li, Tianpeng Hu, Manyi Sun and Ping Lei

important role in axonal development, memory formation and neuroprotection ( Yu et al . 2017 ). An in vivo study suggests that high-fat diet causes cognitive decline and down-regulation of CREB in hippocampus ( Tang et al . 2018 ). Our previous study

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ChengCheng Lin, Bei Shao, YuLei Zhou, XiaoTing Niu and YuanShao Lin

. Nowadays, the most common maternal dietary imbalance in many countries is the excessive intake of dietary fat. There is accumulating evidence supporting that perinatal overnutrition or high-fat diet (HFD) consumption induces health problems in adult

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Susan M van den Berg, Andrea D van Dam, Pascal J H Kusters, Linda Beckers, Myrthe den Toom, Saskia van der Velden, Jan Van den Bossche, Irma van Die, Mariëtte R Boon, Patrick C N Rensen, Esther Lutgens and Menno P J de Winther

cells in adipose tissue is unknown. Due to the important role of eosinophils and macrophages in adipose tissue, we first determined how a high-fat diet (HFD) affects these immune cells in BAT, epididymal WAT (EpAT) and ScAT in a short time course study

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Edra London, Maria Nesterova and Constantine A Stratakis

suggesting the involvement of sex hormones and/or other sex-specific factors with respect to PKA regulation of energy metabolism and homeostasis. To test the hypothesis that chronic high fat diet (HFD) exposure would lead to dysregulation of peripheral and

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Long The Nguyen, Sonia Saad, Yi Tan, Carol Pollock and Hui Chen

, hyperphagia is limited. Studies in rat models of maternal obesity showed that offspring exposed to maternal and postnatal high-fat diet (HFD) exhibit increased density of orexigenic peptide-expressing neurons in the hypothalamus ( Chang et al . 2008

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Maria Sörhede Winzell and Bo Ahrén

selective GLP-1 receptor agonist ( Montrose-Rafizadeh et al . 1997 ). Insulin resistance was induced by feeding female mice with a high-fat diet (HFD), which is a model that has been extensively examined as a tool for studying islet function ( Winzell

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Yueting Dong, Zhiye Xu, Ziyi Zhang, Xueyao Yin, Xihua Lin, Hong Li and Fenping Zheng

maintained on a 12-h light–darkness cycle. After 1 week of habituation fed on regular chow diet (normal diet (ND), carbohydrate, 63.92%; protein, 26.18%; fat, 9.9%), animals were weighed and divided into two groups: the high-fat diet (HFD) group ( n  = 24

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R Buettner, K G Parhofer, M Woenckhaus, C E Wrede, L A Kunz-Schughart, J Schölmerich and L C Bollheimer

of view, experiments with these obesity models will clarify only certain aspects of the metabolic syndrome and contribute little to the overall understanding of this condition’s pathophysiology. The first description of a ‘high-fat diet’ to

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Ke-feng Yang, Wei Cai, Jia-li Xu and Wen Shi

not change between both groups ( Fig. 3 ). Figure 3 Effect of maternal high-fat diet on Wnt mRNA levels in the liver of offspring. Wnt1 , Wnt3a , and Wnt5a mRNA expression levels in the liver of offspring born to dams fed C or HF diet at

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Loes P M Duivenvoorde, Evert M van Schothorst, Annelies Bunschoten and Jaap Keijer

from fat). Only few studies focused on the effect of DR using high-fat diets (HF-DR; Petro et al . 2004 , Kalupahana et al . 2011 , de Meijer et al . 2010 ), which is, in fact, more relevant to the current dietary status in most developed