Search Results

You are looking at 1 - 10 of 15 items for :

  • "hepatic lipogenesis" x
Clear All
Open access

Ting Xiao, Xiuci Liang, Hailan Liu, Feng Zhang, Wen Meng and Fang Hu

SREBP (p-SREBP) to functional mature SREBP (m-SREBP) ( Han & Wang 2018 ). However, the mechanisms underlying ER stress-induced hepatic lipogenesis and steatosis via the mTORC1- SREBP1 signaling pathway are yet to be completely elucidated. Similar to

Free access

Yuumi Ishizuka, Kazuhiro Nakayama, Ayumi Ogawa, Saho Makishima, Supichaya Boonvisut, Atsushi Hirao, Yusaku Iwasaki, Toshihiko Yada, Yoshiko Yanagisawa, Hiroshi Miyashita, Masafumi Takahashi, Sadahiko Iwamoto and Jichi Medical University Promotion Team of a Large-Scale Human Genome Bank for All over Japan

hepatic lipogenesis, which affects very low density lipoprotein (VLDL) production ( Burkhardt et al . 2010 ). However, the molecular mechanisms remain unknown. Therefore, we explored the molecular pathways using a mouse model and functional variations in

Free access

Young Ho Suh, Younyoung Kim, Jeong Hyun Bang, Kyoung Suk Choi, June Woo Lee, Won-Ho Kim, Tae Jeong Oh, Sungwhan An and Myeong Ho Jung

lipogenic genes, deteriorates with prolonged obesity ( Nadler et al. 2000 ) and reduced lipogenic adipocytes are associated with increased hepatic lipogenesis, which may be a shift in the lipogenic burden from adipocytes to other organs such as the liver

Free access

Horng-Yih Ou, Hung-Tsung Wu, Feng-Hwa Lu, Yu-Chu Su, Hao-Chang Hung, Jin-Shang Wu, Yi-Ching Yang, Chao-Liang Wu and Chih-Jen Chang

cells were used to clarify the possible mechanisms of FFAR1-regulated hepatic lipogenesis. Materials and methods Materials Chelethyrine and U73343 were purchased from Sigma–Aldrich. GW9805 and U73122 were purchased from Tocris Bioscience (Ellisville, MO

Free access

Yajie Guo, Junjie Yu, Chunxia Wang, Kai Li, Bin Liu, Ying Du, Fei Xiao, Shanghai Chen and Feifan Guo

has no difference ( Fig. 4F ). Consistent with these changes, lipid accumulation was significantly decreased in the livers of Ad-miR-212 mice, as demonstrated by Oil Red O staining and H&E staining ( Fig. 4G ). Hepatic lipogenesis, β-oxidation, and

Free access

Yueting Dong, Zhiye Xu, Ziyi Zhang, Xueyao Yin, Xihua Lin, Hong Li and Fenping Zheng

). They have shown that loss of LXR impairs hepatic lipogenesis, accompanied by a reciprocal increase in adipose lipid storage, by promoting adipose PPARγ pathway activity, indicating possible cross-talk between LXR and PPARγ in adipose tissue. Cross

Free access

Xiaoting Jiang, Xin Ye, Wei Guo, Hongyun Lu and Zhanguo Gao

differentiation. HDAC1/HDAC3 was reported to modulate PPARγ transcription through the sumoylated CEBPD in hepatic lipogenesis ( Lai et al . 2008 ). However, there is no report that PPARγ was acetylated by HDAC1/HDAC3. Our results indicate that HDAC3 regulates

Free access

Carolina Gustavsson, Tomoyoshi Soga, Erik Wahlström, Mattias Vesterlund, Alireza Azimi, Gunnar Norstedt and Petra Tollet-Egnell

-dependent differences, and to find hepatic parameters that might protect fZDF rats from developing diabetes. By identifying high-fat diet-induced changes in hepatic gene expression, a picture of reduced hepatic lipogenesis and increased FA oxidation and metabolic stress

Free access

Tae Woo Jung, Yoon Hee Chung, Hyoung-Chun Kim, A M Abd El-Aty and Ji Hoon Jeong

hepatic lipogenesis ( Hwang et al . 2015 b ). Therefore, we examined the effect of LECT2 on the differentiation of 3T3-L1 cells. Microscopic evaluation demonstrated that treatment of 3T3-L1 cells with recombinant mouse LECT2 markedly enhanced lipid

Free access

Ke-feng Yang, Wei Cai, Jia-li Xu and Wen Shi

alteration in the fetal development of the liver could exert long-term influences on metabolic capacity. Bruce et al . (2009) reported that maternal HF intake contributes to the development of NAFLD progression and upregulated hepatic lipogenesis in groups