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Nils Wierup, Frank Sundler and R Scott Heller

novel islet cell type, the islet ghrelin cell, has been presented and confirmed by several laboratories. This cell is the fifth cell type to be described in the adult human islets. Further, it is the seventh islet cell with known hormonal content when

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Riccarda Granata, Alessandra Baragli, Fabio Settanni, Francesca Scarlatti and Ezio Ghigo

cells, with the exception of a short perinatal period in rats, when a minor ghrelin cell subpopulation expressed glucagon and PP as well ( Wierup et al . 2002 , 2004 ). More recently, ghrelin and preproghrelin immunostaining have been shown to be

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Chung Thong Lim, Blerina Kola and Márta Korbonits

-Cuenca S 2008 Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin . Cell Metabolism 7 389 – 399 . McBride A Ghilagaber S Nikolaev A Hardie DG 2009 The glycogen-binding domain on the AMPK beta subunit allows the

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C Ruth González, María J Vázquez, Miguel López and Carlos Diéguez

-Tilve D Vázquez MJ Varela L Sangiao-Alvarellos S Tovar S Raghay K Rodriguez-Cuenca S 2008a Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin . Cell Metabolism 7 389 – 399 . López M Saha AK Diéguez C

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Talitha van der Meulen and Mark O Huising

), while β cells are replaced by ghrelin cells ( Prado et al . 2004 ). Within the islet, NKX6-1 functions downstream of NKX2-2 and is both necessary and sufficient for β cell neogenesis during the secondary transition, a time of further differentiation and

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Riccarda Granata, Marco Volante, Fabio Settanni, Carlotta Gauna, Corrado Ghé, Marta Annunziata, Barbara Deidda, Iacopo Gesmundo, Thierry Abribat, Aart-Jan van der Lely, Giampiero Muccioli, Ezio Ghigo and Mauro Papotti

/GHS receptors . Neuroendocrinology 86 147 – 164 . Prado CL Pugh-Bernard AE Elghazi L Sosa-Pineda B Sussel L 2004 Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development . PNAS 101 2924 – 2929

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Andreas Petri, Jonas Ahnfelt-Rønne, Klaus Stensgaard Frederiksen, David George Edwards, Dennis Madsen, Palle Serup, Jan Fleckner and R Scott Heller

. Petri A , Fleckner J & Matthiessen MW 2004 Array-A-Lizer: a serial DNA microarray quality analyzer. BMC Bioinformatics 5 12 . Prado CL , Pugh-Bernard AE, Elghazi L, Sosa-Pineda B & Sussel L 2004 Ghrelin cells

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Cristina Velasco, Cristina Otero-Rodiño, Sara Comesaña, Jesús M Míguez and José L Soengas

mediates the orexigenic action of ghrelin. Cell Metabolism 7 389 – 399 . ( doi:10.1016/j.cmet.2008.03.006 ) 18460330 MacDonald LE Alderman SL Kramer S Woo PTK Bernier NJ 2014 Hypoxemia-induced leptin secretion: a mechanism for

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Cristina Velasco, Sara Comesaña, Marta Conde-Sieira, Jesús M Míguez and José L Soengas

-Alvarellos S Tovar S Raghay K Rodríguez-Cuenca S , et al . 2008 Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin . Cell Metabolism 7 389 – 399 . ( https://doi.org/10.1016/j.cmet.2008.03.006 ) 10.1016/j.cmet.2008

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Luis Varela, María J Vázquez, Fernando Cordido, Rubén Nogueiras, Antonio Vidal-Puig, Carlos Diéguez and Miguel López

Raghay K Rodríguez-Cuenca S 2008a Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin . Cell Metabolism 7 389 – 399 . doi:10.1016/j.cmet.2008.03.006 . López M Saha AK Diéguez C Vidal-Puig A 2008b The AMPK