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Afreen Idris Shariff, Sohail Syed, Rebecca A Shelby, Jeremy Force, Jeffrey Melson Clarke, David D’Alessio and Leonor Corsino

that have breached immune surveillance are targeted and destroyed ( Salvatore et al . 2013 ). However, this mechanism can also lead to unwanted immune actions and a number of autoimmune endocrinopathies have been described with immunologic modulation

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Catherine J Owen, James A Eden, Claire E Jennings, Valerie Wilson, Tim D Cheetham and Simon H S Pearce

Introduction Autoimmune endocrinopathies, including Graves’ disease (GD) and autoimmune Addison’s disease (AAD), are the commonest type of autoimmunity in Western populations. However, their pathogenesis remains poorly defined. Like

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Raquel Tobar-Rubin, Dahlia Sultan, Daniela Janevska, Kyle Turcic, Julie Carroll, Laura Ooms and Robin Pals-Rylaarsdam

with drugs that alleviate each specific endocrinopathy. The consequences of precocious puberty in MAS patients are delayed until the patient approaches a normal age for puberty using aromatase inhibitors and/or tamoxifen ( Eugster et al . 2003

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Xinwang Chen, Xiao Jia, Jie Qiao, Youfei Guan and Jihong Kang

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Dysfunction of adipose tissue has been implicated in the pathophysiology of PCOS. Increasing evidence shows that the dysregulated expression of adipokines, the secreted products of adipose tissue, plays an important role in the pathology of PCOS. Here, we review the role of several identified adipokines that may act as a link between obesity and PCOS. PCOS also reciprocally influences the profile of adipokines. Insight into the underlying mechanisms will help better understand the pathology of PCOS and identify new therapeutic targets of this syndrome.

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Jessica K Devin, Joyce E Johnson, Mesut Eren, Linda A Gleaves, William S Bradham, John R Bloodworth Jr and Douglas E Vaughan

Introduction Approximately 1 in 15 women in the United States is affected by the polycystic ovarian syndrome (PCOS), thus giving it the distinction as the most common endocrinopathy in this age group ( Adams et al. 2004

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C E Jennings, C J Owen, V Wilson and S H S Pearce

tyrosine phosphatase ( LYP ; Bottini et al. 2004 , Smyth et al. 2004 , Velaga et al. 2004 ) genes have been implicated in several autoimmune endocrinopathies including Type 1 diabetes, Graves’ disease (GD) and Addison’s disease. However, there is

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Mara Riminucci, Pamela Gehron Robey, Isabella Saggio and Paolo Bianco

tissues in which the clinical expression of the underlying mutation is either minor or not readily recognized ( Bianco et al . 2003 ). The combination of FD, endocrinopathy, and skin pigmentation is classically known as the McCune–Albright syndrome

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Jian-Hua Chen, Maria Segni, Felicity Payne, Isabel Huang-Doran, Alison Sleigh, Claire Adams, UK10K Consortium, David B Savage, Stephen O'Rahilly, Robert K Semple and Inês Barroso

). Diaz A Vogiatzi MG Sanz MM German J 2006 Evaluation of short stature, carbohydrate metabolism and other endocrinopathies in Bloom's syndrome . Hormone Research 66 111 – 117 . ( doi:10.1159/000093826 ). Ellis NA Groden J Ye TZ

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Ciro Menale, Maria Teresa Piccolo, Grazia Cirillo, Raffaele A Calogero, Alfonso Papparella, Luigi Mita, Emanuele Miraglia Del Giudice, Nadia Diano, Stefania Crispi and Damiano Gustavo Mita

Congenital proprotein convertase 1/3 deficiency causes malabsorptive diarrhea and other endocrinopathies in a pediatric cohort . Gastroenterology 145 138 – 148 . ( doi:10.1053/j.gastro.2013.03.048 ). Masuno H Kidani T Sekiya K Sakayama K Shiosaka

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Nicole Gallo-Payet

essential for homeostasis as well as survival. Disorders of the adrenal glands lead to classical endocrinopathies such as Cushing’s syndrome, Addison’s disease, hyperaldosteronism, and the syndromes of congenital adrenal hyperplasia (CAH) ( Miller & Auchus