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Kate E Lines, Anna K Gluck, Supat Thongjuea, Chas Bountra, Rajesh V Thakker, and Caroline M Gorvin

et al. 2009 , Di Ieva et al. 2014 ). Corticotrophinomas, which secrete adrenocorticotropic hormone (ACTH), represent 10% of all surgically removed pituitary adenomas ( Daly et al. 2009 ). The recommended treatment for corticotrophinomas is trans

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Leandro Nieto, Mariana Fuertes, Josefina Rosmino, Sergio Senin, and Eduardo Arzt

beneficial biological effects ( Burnett et al. 2015 , Abaza et al. 2017 ). Cushing’s disease originates in the excessive production of adrenocorticotropic hormone (ACTH) by a secreting pituitary corticotrophinoma and as a result of this over

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Ivo J P Arnhold, Marcela M França, Luciani R Carvalho, Berenice B Mendonca, and Alexander A L Jorge

-binding domain. Electromobility shift assay demonstrated a lack of binding to a consensus GLI-binding site, and luciferase reporter assay revealed a complete loss of transactivation in mouse embryonic fibroblast (NIH-3T3) as well as murine corticotrophinoma (At