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Liting Wu Department of Endocrinology and Metabolism, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Li Xiong Department of Endocrinology and Metabolism, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Jin Li Department of Endocrinology and Metabolism, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Department of Geriatrics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Zishan Peng Department of Endocrinology and Metabolism, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Luyao Zhang Department of Endocrinology and Metabolism, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Peijie Shi Department of Endocrinology and Metabolism, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Yingying Gong Department of Endocrinology and Metabolism, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Department of Geriatrics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Haipeng Xiao Department of Endocrinology and Metabolism, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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indicates that small RNAs (miRNA) and long non-coding RNAs play key roles in regulating β-cell functions ( Guay et al. 2012 , Nesca et al. 2013 , Motterle et al. 2017 ). However, experimental data linking circular RNAs (circRNAs) to β-cell functions

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Chang-Jiang Wang Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun, Jilin, China

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Fei Gao Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun, Jilin, China

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Yi-Jie Huang Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun, Jilin, China

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Dong-Xu Han Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun, Jilin, China

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Yi Zheng Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun, Jilin, China

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Wen-Hua Wang Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun, Jilin, China

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Hao Jiang Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun, Jilin, China

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Yan Gao Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun, Jilin, China

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Bao Yuan Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun, Jilin, China

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Jia-Bao Zhang Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun, Jilin, China

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maintain energy homeostasis ( Sun et al. 2006 , Liu et al. 2017 ). Consequently, it is crucial to further address the molecular mechanisms involved in FSH regulation. Circular RNAs (circRNAs), a novel class of noncoding RNAs, have attracted great

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Junling Wang Gynecologic Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Hongyan Zhang Gynecologic Department, Hainan Traditional Chinese Medicine Hospital, Haikou, China

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Yue Cao Science and technology department, Guangzhou University of Chinese Medicine, Guangzhou, China

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Irene Ma Gynecologic Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Xuefang Liang Gynecologic Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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Dongfang Xiang Gynecologic Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

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(BMSCs) in postmenopausal OP by targeting miR-135a-5p ( Wang et al. 2019 ). Additionally, emerging evidence indicates that circular RNAs (circRNAs), such as circRNA_0016624 and circRNA_0048211, might play a significant role in the progression of

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Jiayu Jin Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China

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Xinhong Wang Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China

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Xiuling Zhi Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China

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Dan Meng Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China

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metformin-induced activation of DICER, a central enzyme involved in miRNA processing, may also explain why metformin administration can rescue endothelial dysfunction ( Noren Hooten et al. 2016 ). Circular RNAs Circular RNAs (cirRNAs) are a

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Rachel C Quilang Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK

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Sylvia Lui Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
St. Mary’s Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK

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Karen Forbes Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK
Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

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circular RNA (circRNA) actions ( Ding et al. 2021 , Xiao et al. 2021 , Zhang et al. 2021 ). While miR-758-3p do not influence proliferation in the placenta, migration and invasion are also key features of normal placentation ( Knofler & Pollheimer

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Salman Azhar Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California, USA
Division of Endocrinology, Gerontology and Metabolism, Stanford University, Stanford University, Stanford, California, USA
Stanford Diabetes Research Center, Stanford, California, USA

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Dachuan Dong Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California, USA
Division of Endocrinology, Gerontology and Metabolism, Stanford University, Stanford University, Stanford, California, USA

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Wen-Jun Shen Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California, USA
Division of Endocrinology, Gerontology and Metabolism, Stanford University, Stanford University, Stanford, California, USA

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Zhigang Hu Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Science, Nanjing Normal University, Nanjing, China

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Fredric B Kraemer Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California, USA
Division of Endocrinology, Gerontology and Metabolism, Stanford University, Stanford University, Stanford, California, USA
Stanford Diabetes Research Center, Stanford, California, USA

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, natural antisense transcripts, pseudogenes and circular RNAs (circRNAs), ribozymes, ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), small nucleolar RNAs (snRNAs), Piwi-associated RNAs (piRNAs), small nuclear RNAs (snoRNAs), telomere-associated RNAs (TERC

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