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Hong-Wei Chang
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Chao-Yuan Huang Nephrology Division, Department of Urology, Department of Internal Medicine, Room 1419, National Taiwan University Hospital, Clinical Research Building, 7 Chung-Sun South Road, Taipei 100, Taiwan

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Shao-Yu Yang
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Vin-Cent Wu
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Tzong-Shinn Chu
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Yung-Ming Chen
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Bor-Shen Hsieh
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Kwan-Dun Wu
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. Many studies have shown a role of DRD2 in cell proliferation. Activation of DRD2 inhibited proliferation of various cells, such as forebrain neural stem cells, vascular endothelial cells, colon epithelial cells, and lactotrophs ( Saiardi et al . 1997

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-13-0044
Volume/Issue:
Volume 52: Issue 2
Free access
Zhiyu Ma College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China
College of Veterinary Medicine, Yangzhou University, Yangzhou, People’s Republic of China

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Ying Zhang College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Juan Su College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Sheng Yang College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Wenna Qiao College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Xiang Li College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Zhihai Lei College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Ling Cheng College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Na An College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Wenshao Wang College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Yanyan Feng College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

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Jinlong Zhang College of Veterinary Medicine, Yangzhou University, Yangzhou, People’s Republic of China

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), cytosolic Ca 2+ , and intracellular cAMP concentrations, resulting in related gene’s expression, DNA synthesis, and/or cellular effects (hormone secretion and cell proliferation) ( Ohki-Hamazaki 2000 , Jensen et al . 2008 ). The testes is the most

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0242
Volume/Issue:
Volume 61: Issue 1
Free access
Changgui Shi Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China
Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Ping Huang Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Hui Kang Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Bo Hu Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China
Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Jin Qi Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Min Jiang Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Hanbing Zhou Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Lei Guo Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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Lianfu Deng Shanghai Key Laboratory for Bone and Joint Diseases, Department of Orthopedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of China

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proliferation pathways in osteoblasts are still not known. MicroRNAs (miRNAs) are endogenous, non-coding RNAs that are 19–25 nucleotides in length; they regulate various biological processes, including cell proliferation, apoptosis, development, hematopoiesis

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-14-0314
Volume/Issue:
Volume 54: Issue 3
Free access
D Montanaro Departments of Pharmaco-Biology and Cell Biology, University of Calabria, 87036 Arcavacata di Rende (CS), Italy
Department of Histology, Microbiology and Medical Biotechnologies and
Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, 35128 Padova, Italy

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M Maggiolini Departments of Pharmaco-Biology and Cell Biology, University of Calabria, 87036 Arcavacata di Rende (CS), Italy
Department of Histology, Microbiology and Medical Biotechnologies and
Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, 35128 Padova, Italy

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A G Recchia Departments of Pharmaco-Biology and Cell Biology, University of Calabria, 87036 Arcavacata di Rende (CS), Italy
Department of Histology, Microbiology and Medical Biotechnologies and
Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, 35128 Padova, Italy

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R Sirianni Departments of Pharmaco-Biology and Cell Biology, University of Calabria, 87036 Arcavacata di Rende (CS), Italy
Department of Histology, Microbiology and Medical Biotechnologies and
Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, 35128 Padova, Italy

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S Aquila Departments of Pharmaco-Biology and Cell Biology, University of Calabria, 87036 Arcavacata di Rende (CS), Italy
Department of Histology, Microbiology and Medical Biotechnologies and
Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, 35128 Padova, Italy

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L Barzon Departments of Pharmaco-Biology and Cell Biology, University of Calabria, 87036 Arcavacata di Rende (CS), Italy
Department of Histology, Microbiology and Medical Biotechnologies and
Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, 35128 Padova, Italy

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F Fallo Departments of Pharmaco-Biology and Cell Biology, University of Calabria, 87036 Arcavacata di Rende (CS), Italy
Department of Histology, Microbiology and Medical Biotechnologies and
Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, 35128 Padova, Italy

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S Andò Departments of Pharmaco-Biology and Cell Biology, University of Calabria, 87036 Arcavacata di Rende (CS), Italy
Department of Histology, Microbiology and Medical Biotechnologies and
Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, 35128 Padova, Italy

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V Pezzi Departments of Pharmaco-Biology and Cell Biology, University of Calabria, 87036 Arcavacata di Rende (CS), Italy
Department of Histology, Microbiology and Medical Biotechnologies and
Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, 35128 Padova, Italy

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stripped and reprobed with β-actin antiserum. Cell-proliferation assay A total of 1 × 10 6 cells were seeded onto six-well plates in complete medium, for proliferative analysis. After 3 days the medium was replaced with

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01806
Volume/Issue:
Volume 35: Issue 2
Free access
Yujia Pan Key Lab of Etiology and Epidemiology, National Health and Family Planning Commission, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, China
Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, Heilongjiang, China
College of Medical Laboratory Science, Guilin Medical University, Guilin, Guangxi, China

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Weikang Yun Department of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China

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Bingshuai Shi Department of Thyroid Surgery, First Affiliated Hospital of Henan University, Kaifeng, Henan, China

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Rongjun Cui Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, Heilongjiang, China

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Chi Liu Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, Heilongjiang, China

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Zhong Ding Kaifeng Center for Disease Prevention and Control, Kaifeng, Henan, China

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Jialin Fan Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, Heilongjiang, China

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Wenqian Jiang Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, Heilongjiang, China

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Jiebing Tang Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China

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Tianhu Zheng Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, Heilongjiang, China

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Xiaoguang Yu Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, Heilongjiang, China

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Ying Liu Key Lab of Etiology and Epidemiology, National Health and Family Planning Commission, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, China

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auto-regulatory, curbing cell proliferation and thyroid function ( Eng et al. 1999 , Leoni et al. 2008 ). In addition, iodine excess may play a protective role in the activation of oncogenic RET/PTC3 in thyroid follicular cells, obstructing the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-19-0198
Volume/Issue:
Volume 65: Issue 2
Restricted access
J Liu
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X-D Li
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A Vaheri
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R Voutilainen
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demonstrated with a commercial cell proliferation kit (Amersham) to detect 5-bromo-2′-deoxyuridine (BrdU) incorporation into the replicating DNA. MeCP2 was detected with a polyclonal antibody (Upstate Ltd, Milton Keynes, UK). During the staining, the primary

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01560
Volume/Issue:
Volume 33: Issue 3
Free access
Daniela Pasquali Endocrine Unit, Endo-Surgery Unit, Pathology Section, Radiology, Department of Clinical and Experimental Medicine and Surgery and

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Valentina Rossi Endocrine Unit, Endo-Surgery Unit, Pathology Section, Radiology, Department of Clinical and Experimental Medicine and Surgery and

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Giovanni Conzo Endocrine Unit, Endo-Surgery Unit, Pathology Section, Radiology, Department of Clinical and Experimental Medicine and Surgery and

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Giuseppe Pannone Endocrine Unit, Endo-Surgery Unit, Pathology Section, Radiology, Department of Clinical and Experimental Medicine and Surgery and

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Pantaleo Bufo Endocrine Unit, Endo-Surgery Unit, Pathology Section, Radiology, Department of Clinical and Experimental Medicine and Surgery and

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Annamaria De Bellis Endocrine Unit, Endo-Surgery Unit, Pathology Section, Radiology, Department of Clinical and Experimental Medicine and Surgery and

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Andrea Renzullo Endocrine Unit, Endo-Surgery Unit, Pathology Section, Radiology, Department of Clinical and Experimental Medicine and Surgery and

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Giuseppe Bellastella Endocrine Unit, Endo-Surgery Unit, Pathology Section, Radiology, Department of Clinical and Experimental Medicine and Surgery and

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Annamaria Colao Endocrine Unit, Endo-Surgery Unit, Pathology Section, Radiology, Department of Clinical and Experimental Medicine and Surgery and

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Gianfranco Vallone Endocrine Unit, Endo-Surgery Unit, Pathology Section, Radiology, Department of Clinical and Experimental Medicine and Surgery and

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Antonio Bellastella Endocrine Unit, Endo-Surgery Unit, Pathology Section, Radiology, Department of Clinical and Experimental Medicine and Surgery and

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Antonio A Sinisi Endocrine Unit, Endo-Surgery Unit, Pathology Section, Radiology, Department of Clinical and Experimental Medicine and Surgery and

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.9. Experiments were repeated at least thrice and represented as folds of expression. Cell proliferation assay Cell proliferation was evaluated with the tetrazolium salt (MTT) method as previously described ( Pasquali et al . 2000 ). The MTT Cell Proliferation

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-08-0012
Volume/Issue:
Volume 40: Issue 6
Free access
Kay E Garnett School of Biological Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK

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Philip Chapman School of Biological Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK

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Julie A Chambers School of Biological Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK

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Ian D Waddell School of Biological Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK

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David S W Boam School of Biological Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK

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on β-cell function. We performed further studies on the immediate-early gene, Egr-1, which was down-regulated in ZDF islets, because other studies suggest it plays a role in the regulation of cell proliferation, differentiation and survival ( Perez

Article Type:
Research Article
DOI:
https://doi.org/10.1677/jme.1.01792
Volume/Issue:
Volume 35: Issue 1
Free access
Chanchal Gupta Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Mohali, Punjab-160062, India

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Kulbhushan Tikoo Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Mohali, Punjab-160062, India

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(bladder cancer cell), HCT-116 (colorectal cancer cell), and PC-3 (prostate cancer cell) proliferation ( Weinstein et al . 2009 , Liu et al . 2011 b ). These reports indicate that metabolic changes occurring in patients with hyperglycemia and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-13-0062
Volume/Issue:
Volume 51: Issue 1
Free access
Maria Cernea Departments of Obstetrics and Gynaecology, and Physiology and Pharmacology, Children's Health Research Institute and Lawson Health Research Institute, Western University, Room A5-132, 800 Commissioners Road East, London, Ontario, Canada, N6C 2V5

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Wei Tang Departments of Obstetrics and Gynaecology, and Physiology and Pharmacology, Children's Health Research Institute and Lawson Health Research Institute, Western University, Room A5-132, 800 Commissioners Road East, London, Ontario, Canada, N6C 2V5

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Haiyan Guan Departments of Obstetrics and Gynaecology, and Physiology and Pharmacology, Children's Health Research Institute and Lawson Health Research Institute, Western University, Room A5-132, 800 Commissioners Road East, London, Ontario, Canada, N6C 2V5

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Kaiping Yang Departments of Obstetrics and Gynaecology, and Physiology and Pharmacology, Children's Health Research Institute and Lawson Health Research Institute, Western University, Room A5-132, 800 Commissioners Road East, London, Ontario, Canada, N6C 2V5

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involvement of Wisp1 in mediating Bmp3 -induced MSC proliferation. We first determined if Bmp3 -induced upregulation of Wisp1 expression preceded Bmp3 -stimulated cell proliferation by conducting a time-dependent experiment. We showed that Bmp3

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-15-0217
Volume/Issue:
Volume 56: Issue 1
Free access