Filter

Refine by access

Refine by date

—
  • Print
  • Save

Search Results

You are looking at 1 - 10 of 203 items for :

  • "cell apoptosis" x
  • Refine by access: All content x
Clear All
Zhiyu Ma College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China
College of Veterinary Medicine, Yangzhou University, Yangzhou, People’s Republic of China

Search for other papers by Zhiyu Ma in
Google Scholar
PubMed Close
,
Ying Zhang College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Ying Zhang in
Google Scholar
PubMed Close
,
Juan Su College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Juan Su in
Google Scholar
PubMed Close
,
Sheng Yang College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Sheng Yang in
Google Scholar
PubMed Close
,
Wenna Qiao College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Wenna Qiao in
Google Scholar
PubMed Close
,
Xiang Li College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Xiang Li in
Google Scholar
PubMed Close
,
Zhihai Lei College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Zhihai Lei in
Google Scholar
PubMed Close
,
Ling Cheng College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Ling Cheng in
Google Scholar
PubMed Close
,
Na An College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Na An in
Google Scholar
PubMed Close
,
Wenshao Wang College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Wenshao Wang in
Google Scholar
PubMed Close
,
Yanyan Feng College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Search for other papers by Yanyan Feng in
Google Scholar
PubMed Close
, and
Jinlong Zhang College of Veterinary Medicine, Yangzhou University, Yangzhou, People’s Republic of China

Search for other papers by Jinlong Zhang in
Google Scholar
PubMed Close

(Beyotime) according to the manufacturer’s protocol, and the absorbance was read at 570 nm on a Microplate Reader (Bio-Rad). Cell apoptosis (FITC) assay Cells undergoing apoptosis were assessed using the FITC Annexin V Apoptosis Detection Kit I (BD

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-17-0242
Volume/Issue:
Volume 61: Issue 1
Free access
Kanchana Suksri Department of Physiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

Search for other papers by Kanchana Suksri in
Google Scholar
PubMed Close
,
Namoiy Semprasert Department of Physiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

Search for other papers by Namoiy Semprasert in
Google Scholar
PubMed Close
,
Mutita Junking Division of Molecular Medicine, Research Department, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

Search for other papers by Mutita Junking in
Google Scholar
PubMed Close
,
Suchanoot Kutpruek Department of Physiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

Search for other papers by Suchanoot Kutpruek in
Google Scholar
PubMed Close
,
Thawornchai Limjindaporn Department of Anatomy, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

Search for other papers by Thawornchai Limjindaporn in
Google Scholar
PubMed Close
,
Pa-thai Yenchitsomanus Division of Molecular Medicine, Research Department, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

Search for other papers by Pa-thai Yenchitsomanus in
Google Scholar
PubMed Close
, and
Suwattanee Kooptiwut Department of Physiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

Search for other papers by Suwattanee Kooptiwut in
Google Scholar
PubMed Close

( van Raalte et al. 2012 ). However, the molecular mechanisms through which GCs directly induced pancreatic β-cell apoptosis have not yet been well established. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-20-0238
Volume/Issue:
Volume 67: Issue 3
Restricted access
Li Zhang
Search for other papers by Li Zhang in
Google Scholar
PubMed Close
,
Jie Gao
Search for other papers by Jie Gao in
Google Scholar
PubMed Close
, and
Sheng Cui State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China

Search for other papers by Sheng Cui in
Google Scholar
PubMed Close

-β-induced granulosa cell proliferation and granulosa cell functions by targeting SMAD4 ( Yao et al . 2010 ). MicroRNA-21 was shown to regulate granulosa cell apoptosis, and in vivo knockdown of miR-21 causes an increase in apoptosis ( Carletti et al . 2010

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-16-0248
Volume/Issue:
Volume 58: Issue 4
Free access
Ray-Jade Chen Trauma and Emergency Center, School of Medicine, Division of Cardiology, Graduate Institute of Chinese Medical Science, School of Applied Chemistry, Institute of Biochemistry and Biotechnology, Division of Gastroenterology, Department of Pediatrics, Department of Healthcare Administration, Division of Medical Technology, Graduate Institute of Basic Medical Science, Department of Health and Nutrition Biotechnology, China Medical University Hospital, Taichung 404, Taiwan, ROC

Search for other papers by Ray-Jade Chen in
Google Scholar
PubMed Close
,
His-Chin Wu Trauma and Emergency Center, School of Medicine, Division of Cardiology, Graduate Institute of Chinese Medical Science, School of Applied Chemistry, Institute of Biochemistry and Biotechnology, Division of Gastroenterology, Department of Pediatrics, Department of Healthcare Administration, Division of Medical Technology, Graduate Institute of Basic Medical Science, Department of Health and Nutrition Biotechnology, China Medical University Hospital, Taichung 404, Taiwan, ROC

Search for other papers by His-Chin Wu in
Google Scholar
PubMed Close
,
Mu-Hsin Chang Trauma and Emergency Center, School of Medicine, Division of Cardiology, Graduate Institute of Chinese Medical Science, School of Applied Chemistry, Institute of Biochemistry and Biotechnology, Division of Gastroenterology, Department of Pediatrics, Department of Healthcare Administration, Division of Medical Technology, Graduate Institute of Basic Medical Science, Department of Health and Nutrition Biotechnology, China Medical University Hospital, Taichung 404, Taiwan, ROC

Search for other papers by Mu-Hsin Chang in
Google Scholar
PubMed Close
,
Chao-Hung Lai Trauma and Emergency Center, School of Medicine, Division of Cardiology, Graduate Institute of Chinese Medical Science, School of Applied Chemistry, Institute of Biochemistry and Biotechnology, Division of Gastroenterology, Department of Pediatrics, Department of Healthcare Administration, Division of Medical Technology, Graduate Institute of Basic Medical Science, Department of Health and Nutrition Biotechnology, China Medical University Hospital, Taichung 404, Taiwan, ROC

Search for other papers by Chao-Hung Lai in
Google Scholar
PubMed Close
,
Yun-Chen Tien Trauma and Emergency Center, School of Medicine, Division of Cardiology, Graduate Institute of Chinese Medical Science, School of Applied Chemistry, Institute of Biochemistry and Biotechnology, Division of Gastroenterology, Department of Pediatrics, Department of Healthcare Administration, Division of Medical Technology, Graduate Institute of Basic Medical Science, Department of Health and Nutrition Biotechnology, China Medical University Hospital, Taichung 404, Taiwan, ROC

Search for other papers by Yun-Chen Tien in
Google Scholar
PubMed Close
,
Jin-Ming Hwang Trauma and Emergency Center, School of Medicine, Division of Cardiology, Graduate Institute of Chinese Medical Science, School of Applied Chemistry, Institute of Biochemistry and Biotechnology, Division of Gastroenterology, Department of Pediatrics, Department of Healthcare Administration, Division of Medical Technology, Graduate Institute of Basic Medical Science, Department of Health and Nutrition Biotechnology, China Medical University Hospital, Taichung 404, Taiwan, ROC
Trauma and Emergency Center, School of Medicine, Division of Cardiology, Graduate Institute of Chinese Medical Science, School of Applied Chemistry, Institute of Biochemistry and Biotechnology, Division of Gastroenterology, Department of Pediatrics, Department of Healthcare Administration, Division of Medical Technology, Graduate Institute of Basic Medical Science, Department of Health and Nutrition Biotechnology, China Medical University Hospital, Taichung 404, Taiwan, ROC

Search for other papers by Jin-Ming Hwang in
Google Scholar
PubMed Close
,
Wu-Hsien Kuo Trauma and Emergency Center, School of Medicine, Division of Cardiology, Graduate Institute of Chinese Medical Science, School of Applied Chemistry, Institute of Biochemistry and Biotechnology, Division of Gastroenterology, Department of Pediatrics, Department of Healthcare Administration, Division of Medical Technology, Graduate Institute of Basic Medical Science, Department of Health and Nutrition Biotechnology, China Medical University Hospital, Taichung 404, Taiwan, ROC

Search for other papers by Wu-Hsien Kuo in
Google Scholar
PubMed Close
,
Fuu-Jen Tsai Trauma and Emergency Center, School of Medicine, Division of Cardiology, Graduate Institute of Chinese Medical Science, School of Applied Chemistry, Institute of Biochemistry and Biotechnology, Division of Gastroenterology, Department of Pediatrics, Department of Healthcare Administration, Division of Medical Technology, Graduate Institute of Basic Medical Science, Department of Health and Nutrition Biotechnology, China Medical University Hospital, Taichung 404, Taiwan, ROC

Search for other papers by Fuu-Jen Tsai in
Google Scholar
PubMed Close
,
Chang-Hai Tsai Trauma and Emergency Center, School of Medicine, Division of Cardiology, Graduate Institute of Chinese Medical Science, School of Applied Chemistry, Institute of Biochemistry and Biotechnology, Division of Gastroenterology, Department of Pediatrics, Department of Healthcare Administration, Division of Medical Technology, Graduate Institute of Basic Medical Science, Department of Health and Nutrition Biotechnology, China Medical University Hospital, Taichung 404, Taiwan, ROC

Search for other papers by Chang-Hai Tsai in
Google Scholar
PubMed Close
,
Li-Mien Chen Trauma and Emergency Center, School of Medicine, Division of Cardiology, Graduate Institute of Chinese Medical Science, School of Applied Chemistry, Institute of Biochemistry and Biotechnology, Division of Gastroenterology, Department of Pediatrics, Department of Healthcare Administration, Division of Medical Technology, Graduate Institute of Basic Medical Science, Department of Health and Nutrition Biotechnology, China Medical University Hospital, Taichung 404, Taiwan, ROC

Search for other papers by Li-Mien Chen in
Google Scholar
PubMed Close
,
Chih-Yang Huang Trauma and Emergency Center, School of Medicine, Division of Cardiology, Graduate Institute of Chinese Medical Science, School of Applied Chemistry, Institute of Biochemistry and Biotechnology, Division of Gastroenterology, Department of Pediatrics, Department of Healthcare Administration, Division of Medical Technology, Graduate Institute of Basic Medical Science, Department of Health and Nutrition Biotechnology, China Medical University Hospital, Taichung 404, Taiwan, ROC
Trauma and Emergency Center, School of Medicine, Division of Cardiology, Graduate Institute of Chinese Medical Science, School of Applied Chemistry, Institute of Biochemistry and Biotechnology, Division of Gastroenterology, Department of Pediatrics, Department of Healthcare Administration, Division of Medical Technology, Graduate Institute of Basic Medical Science, Department of Health and Nutrition Biotechnology, China Medical University Hospital, Taichung 404, Taiwan, ROC
Trauma and Emergency Center, School of Medicine, Division of Cardiology, Graduate Institute of Chinese Medical Science, School of Applied Chemistry, Institute of Biochemistry and Biotechnology, Division of Gastroenterology, Department of Pediatrics, Department of Healthcare Administration, Division of Medical Technology, Graduate Institute of Basic Medical Science, Department of Health and Nutrition Biotechnology, China Medical University Hospital, Taichung 404, Taiwan, ROC

Search for other papers by Chih-Yang Huang in
Google Scholar
PubMed Close
, and
Chun-Hsien Chu Trauma and Emergency Center, School of Medicine, Division of Cardiology, Graduate Institute of Chinese Medical Science, School of Applied Chemistry, Institute of Biochemistry and Biotechnology, Division of Gastroenterology, Department of Pediatrics, Department of Healthcare Administration, Division of Medical Technology, Graduate Institute of Basic Medical Science, Department of Health and Nutrition Biotechnology, China Medical University Hospital, Taichung 404, Taiwan, ROC

Search for other papers by Chun-Hsien Chu in
Google Scholar
PubMed Close

, cell apoptosis regulation in response to vast stresses is divided from either initiating the intrinsic or extrinsic pathway, thereby triggering caspases cascade activation ( Riedl & Shi 2004 ). Studies of IGFs in a pressure overload animal model have

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-08-0121
Volume/Issue:
Volume 43: Issue 6
Free access
Shuai Shao Department of Obstetrics and Gynecology, Linyi Peoples Hospital, Linyi, China

Search for other papers by Shuai Shao in
Google Scholar
PubMed Close
,
Hui Wang Department of Obstetrics and Gynecology, Linyi Peoples Hospital, Linyi, China

Search for other papers by Hui Wang in
Google Scholar
PubMed Close
,
Wei Shao Department of Chinese Medicine Preparation, Pingyi County Hospital of Traditional Chinese Medicine, Pingyi, China

Search for other papers by Wei Shao in
Google Scholar
PubMed Close
, and
Na Liu Department of Acupuncture, Linyi Peoples Hospital, Linyi, China

Search for other papers by Na Liu in
Google Scholar
PubMed Close

et al. 2014 ). Interestingly, WT1 knockdown can accelerate hepatocellular carcinoma cell apoptosis by blocking the janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway ( Lv et al. 2015 ), which is also one of the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-20-0077
Volume/Issue:
Volume 65: Issue 4
Restricted access
Laura de Miguel-Santos Departamento de Bioquímica y Biología Molecular II, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Departamento de Metabolismo y Nutrición, Facultad de Farmacia, Universidad Complutense de Madrid, UCM, 28040 Madrid, Spain
Departamento de Bioquímica y Biología Molecular II, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Departamento de Metabolismo y Nutrición, Facultad de Farmacia, Universidad Complutense de Madrid, UCM, 28040 Madrid, Spain

Search for other papers by Laura de Miguel-Santos in
Google Scholar
PubMed Close
,
Elisa Fernández-Millán Departamento de Bioquímica y Biología Molecular II, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Departamento de Metabolismo y Nutrición, Facultad de Farmacia, Universidad Complutense de Madrid, UCM, 28040 Madrid, Spain

Search for other papers by Elisa Fernández-Millán in
Google Scholar
PubMed Close
,
María Ángeles Martín Departamento de Bioquímica y Biología Molecular II, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Departamento de Metabolismo y Nutrición, Facultad de Farmacia, Universidad Complutense de Madrid, UCM, 28040 Madrid, Spain
Departamento de Bioquímica y Biología Molecular II, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Departamento de Metabolismo y Nutrición, Facultad de Farmacia, Universidad Complutense de Madrid, UCM, 28040 Madrid, Spain

Search for other papers by María Ángeles Martín in
Google Scholar
PubMed Close
,
Fernando Escrivá Departamento de Bioquímica y Biología Molecular II, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Departamento de Metabolismo y Nutrición, Facultad de Farmacia, Universidad Complutense de Madrid, UCM, 28040 Madrid, Spain
Departamento de Bioquímica y Biología Molecular II, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Departamento de Metabolismo y Nutrición, Facultad de Farmacia, Universidad Complutense de Madrid, UCM, 28040 Madrid, Spain

Search for other papers by Fernando Escrivá in
Google Scholar
PubMed Close
, and
Carmen Álvarez Departamento de Bioquímica y Biología Molecular II, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Departamento de Metabolismo y Nutrición, Facultad de Farmacia, Universidad Complutense de Madrid, UCM, 28040 Madrid, Spain
Departamento de Bioquímica y Biología Molecular II, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Departamento de Metabolismo y Nutrición, Facultad de Farmacia, Universidad Complutense de Madrid, UCM, 28040 Madrid, Spain

Search for other papers by Carmen Álvarez in
Google Scholar
PubMed Close

( Hogg et al . 1994 , Petrik et al . 1998 ). Both IGFs are considered as survival factors by inhibiting β-cell apoptosis. It has been shown that the transient wave of apoptosis that occurs in developing rat islets between the first and second week of

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JME-09-0045
Volume/Issue:
Volume 44: Issue 1
Free access
Guojun Shi Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China
Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Guojun Shi in
Google Scholar
PubMed Close
,
Chen Sun Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China
Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Chen Sun in
Google Scholar
PubMed Close
,
Weiqiong Gu Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Weiqiong Gu in
Google Scholar
PubMed Close
,
Minglan Yang Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Minglan Yang in
Google Scholar
PubMed Close
,
Xiaofang Zhang Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Xiaofang Zhang in
Google Scholar
PubMed Close
,
Nan Zhai Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Nan Zhai in
Google Scholar
PubMed Close
,
Yan Lu Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Yan Lu in
Google Scholar
PubMed Close
,
Zhijian Zhang Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Zhijian Zhang in
Google Scholar
PubMed Close
,
Peishun Shou Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Peishun Shou in
Google Scholar
PubMed Close
,
Zhiguo Zhang Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Zhiguo Zhang in
Google Scholar
PubMed Close
, and
Guang Ning Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China
Shanghai Institute of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, Key Laboratory of Stem Cell Biology, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU), Shanghai Clinical Center for Endocrine and Metabolic Diseases and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197th Ruijin 2nd Road, Shanghai 200025, China

Search for other papers by Guang Ning in
Google Scholar
PubMed Close

carried out with four replicates for each assay. * P <0.05, ** P <0.01, *** P <0.001, control vs treatment. FFAR2 overexpression increases cell apoptosis, cytosolic Ca 2 + concentration, and ROS level FCM assays with annexin V and PI staining revealed a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-14-0065
Volume/Issue:
Volume 53: Issue 3
Free access
Qun Cheng Diabetes Research Laboratory, Shanghai Geriatric Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated First People's Hospital, 100 Hainin Road, Shanghai 200080, People's Republic of China
Diabetes Research Laboratory, Shanghai Geriatric Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated First People's Hospital, 100 Hainin Road, Shanghai 200080, People's Republic of China

Search for other papers by Qun Cheng in
Google Scholar
PubMed Close
,
Weipin Dong Diabetes Research Laboratory, Shanghai Geriatric Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated First People's Hospital, 100 Hainin Road, Shanghai 200080, People's Republic of China

Search for other papers by Weipin Dong in
Google Scholar
PubMed Close
,
Lei Qian Diabetes Research Laboratory, Shanghai Geriatric Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated First People's Hospital, 100 Hainin Road, Shanghai 200080, People's Republic of China

Search for other papers by Lei Qian in
Google Scholar
PubMed Close
,
Jingcheng Wu Diabetes Research Laboratory, Shanghai Geriatric Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated First People's Hospital, 100 Hainin Road, Shanghai 200080, People's Republic of China

Search for other papers by Jingcheng Wu in
Google Scholar
PubMed Close
, and
Yongde Peng Diabetes Research Laboratory, Shanghai Geriatric Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated First People's Hospital, 100 Hainin Road, Shanghai 200080, People's Republic of China

Search for other papers by Yongde Peng in
Google Scholar
PubMed Close

inhibit the action of insulin and to cause apoptosis in a variety of cell types. Specifically, it plays key roles in obesity-associated islet cell apoptosis and thus has a substantial impact on the progress of diabetes. Moreover, it has been reported that

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-10-0106
Volume/Issue:
Volume 47: Issue 1
Free access
Fabio Arturo Grieco ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

Search for other papers by Fabio Arturo Grieco in
Google Scholar
PubMed Close
,
Andrea Alex Schiavo ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

Search for other papers by Andrea Alex Schiavo in
Google Scholar
PubMed Close
,
Flora Brozzi ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

Search for other papers by Flora Brozzi in
Google Scholar
PubMed Close
,
Jonas Juan-Mateu ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

Search for other papers by Jonas Juan-Mateu in
Google Scholar
PubMed Close
,
Marco Bugliani Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa, Pisa, Italy

Search for other papers by Marco Bugliani in
Google Scholar
PubMed Close
,
Piero Marchetti Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa, Pisa, Italy

Search for other papers by Piero Marchetti in
Google Scholar
PubMed Close
, and
Décio L Eizirik ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium

Search for other papers by Décio L Eizirik in
Google Scholar
PubMed Close

) and other regulators of the UPR. ATF4 increases the expression of two important transcription factors, namely ATF3 and eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3, also known as PERK), which contribute to beta cell apoptosis

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-19-0066
Volume/Issue:
Volume 63: Issue 2
Free access
Xiaodan Li College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, China

Search for other papers by Xiaodan Li in
Google Scholar
PubMed Close
,
Xiaolei Yao College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, China

Search for other papers by Xiaolei Yao in
Google Scholar
PubMed Close
,
Yongjin Bao College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, China

Search for other papers by Yongjin Bao in
Google Scholar
PubMed Close
,
Kaiping Deng College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, China

Search for other papers by Kaiping Deng in
Google Scholar
PubMed Close
,
Mingtian Deng College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, China

Search for other papers by Mingtian Deng in
Google Scholar
PubMed Close
,
Fan Yang College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, China

Search for other papers by Fan Yang in
Google Scholar
PubMed Close
,
Xuan Sun College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, China

Search for other papers by Xuan Sun in
Google Scholar
PubMed Close
,
Peihua You College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, China

Search for other papers by Peihua You in
Google Scholar
PubMed Close
,
Qingxian Cai College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, China

Search for other papers by Qingxian Cai in
Google Scholar
PubMed Close
, and
Feng Wang College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, China

Search for other papers by Feng Wang in
Google Scholar
PubMed Close

cells at different stages of the cell cycle. All data were collected from at least 10,000 cells per sample. Analysis of cell apoptosis Cell apoptosis was measured using annexin V-fluorescein isothiocyanate (FITC) apoptosis detection Kit (BD

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JME-22-0130
Volume/Issue:
Volume 70: Issue 4
Restricted access