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Claire V Harper, Anne V McNamara, David G Spiller, Jayne C Charnock, Michael R H White, and Julian R E Davis

, Raj et al. 2006 , Kangaspeska et al. 2008 ). As well as the role of chromatin modifications on transcriptional heterogeneity, the link between calcium signalling and transcription has been well-reported. Studies from around three decades ago

Open access

Shree Senthil Kumar, Marie-Louise Ward, and Kathleen Grace Mountjoy

intracellular calcium. Because α-MSH-induced [Ca 2+ ] i in HEK293 cells is not associated with an increase in inositol triphosphate but is significantly attenuated by cholera toxin and therefore dependent on Gαs ( Mountjoy et al. 2001 ), the signalling

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Parmita Kar and Ravinder Goswami

striatum tissues and also developed an ex vivo model of BGC using rat striatal cells cultured under high phosphate and low calcium milieu ( Kar et al. 2021 ). The hyperphosphatemic state, characteristic of hypoparathyroidism, achieved by the addition of

Free access

Yefei Pang and Peter Thomas

mediating this rapid progesterone action on VSMC relaxation through mPRα, particularly changes in intracellular calcium levels, their regulation by intracellular signaling pathways, and the involvement changes in RhoA/Rho kinase (ROCK) signaling, have not

Free access

Takumi Nakamura, Kazuki Harada, Taichi Kamiya, Mai Takizawa, Jim Küppers, Kazuo Nakajima, Michael Gütschow, Tetsuya Kitaguchi, Kunihiro Ohta, Tadafumi Kato, and Takashi Tsuboi

), calcium-sensing receptor (CaSR), TAS1R1, and TAS1R3. We found no significant involvement of GPRC6A and CaSR in the increase of [Ca 2+ ] i and [cAMP] i . Furthermore, a TAS1R3 antagonist partially suppressed the increase in [cAMP] i , suggesting the role

Free access

J Gu, A Y S Law, B H Y Yeung, and C K C Wong

Introduction Calcium ions have a variety of beneficial roles in living organisms. Their function is pleiotropic, ranging from the regulation of signaling cascades in a single cell to a wide variety of physiological functions at the organ level

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Caroline M Gorvin

Introduction to the CASR Extracellular calcium (Ca 2+ e ) is required for diverse biological functions ranging from blood coagulation, mineralisation of bone matrix, muscle contraction and hormone secretion ( Brown 1991 ). Thus, calcium

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Jung Ok Lee, Nami Kim, Hye Jeong Lee, Yong Woo Lee, Joong Kwan Kim, Hyung Ip Kim, Soo Kyung Lee, Su Jin Kim, Sun Hwa Park, and Hyeon Soo Kim

uptake ( Jensen et al . 2007 ). CaMKK is activated by elevated intracellular calcium. To corroborate the role of CaMKK in visfatin-mediated glucose uptake, intracellular Ca 2 + levels were measured in the presence of visfatin. Visfatin treatment

Open access

Hasnat Ali Abid, Asuka Inoue, and Caroline M Gorvin

Introduction The calcium-sensing receptor (CaSR) is a class C homo-dimeric G protein-coupled receptor (GPCR) that plays a fundamental role in extracellular calcium (Ca 2+ e ) homeostasis by regulating parathyroid hormone (PTH) release and

Free access

David E C Cole, Francisco H J Yun, Betty Y L Wong, Andrew Y Shuen, Ronald A Booth, Alfredo Scillitani, Svetlana Pidasheva, Xiang Zhou, Lucie Canaff, and Geoffrey N Hendy

Introduction The calcium-sensing receptor (CASR) is a plasma membrane G-protein-coupled receptor (GPCR) abundantly expressed in the parathyroid gland and kidney tubule where it plays a key role as the ‘calciostat’, maintaining extracellular fluid